Determinarea toxicităţii acute a unor noi compuşi chimici cu proprietăţi antituberculoase

La Institutul de Chimie al AŞM au fost sintetizaţi compusi, principalele substanţe active ale cărora reprezintă derivaţi ai oxadiazolilor. Datele preliminare ale testărilor in vitro au determinat activitatea inhibitorie asupra creşterii coloniilor M.tuberculosis. În cadrul proiectului „De la compuşi naturali la analogii lor şi spre evaluarea preclinică a noilor compuşi cu proprietăţi antituberculoase” la Centrul Ştiinţific al Medicamentului al IP USMF „Nicolae Testemiţanu” a fost evaluată toxicitatea acută a 7 compuşi sintetizaţi. Pentru compuşii MF51, MF14 s-a constatat toxicitatea minimă, ei fiind plasaţi în clasa de toxicitate 5 conform TG 423 Acute Toxic Class Method (OECD)

RECENT TRENDS IN ALGINATE, CHITOSAN AND ALGINATE-CHITOSAN ANTIMICROBIAL SYSTEMS

Natural polysaccharides alginate and chitosan have been used extensively, separately or in mixtures (systems), in manufacturing of pharmaceutical products (antimicrobial) and not only. Alginates usually serve as basis for antimicrobial systems, while chitosan, in certain proportions, enhances their physicochemical and antimicrobial properties. Focusing on the recent literature (mostly since 2000), this review outlines the main synthetic approaches for the preparation of systems based on both polymers as well as identify potential areas of their application as antimicrobial agents. Various techniques used for systems preparation like microparticles, films, fibers, nanoparticles, sponges, applications and usefulness of these systems as carriers of antimicrobial compounds will also be discussed

ARMC: the logical choice for software model checking with abstraction refinement

Abstract. Software model checking with abstraction refinement is emerging as a practical approach to verify industrial software systems. Its distinguishing characteristics lie in the way it applies logical reasoning to deal with abstraction. It is therefore natural to investigate whether and how the use of a constraint-based programming language may lead to an elegant and concise implementation of a practical tool. In this paper we describe the outcome of our investigation. Using a Prolog system together with Constraint Logic Programming extensions as the implementation platform of our choice we have built such a tool, called ARMC (for Abstraction Refinement Model Checking), which has already been used for practical verification.

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

Objective To develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment. Methods To illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks. Results As of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.5% of the NMOSD cases and 71.7% of the controls continue in active follow-up. Consanguineous relatives of patients with NMOSD represented 43.6% of the control cohort. Of the 599 active cases with complete data, 84% were female, and 76% were anti-AQP4 seropositive. The majority were white/Caucasian (52.6%), whereas blacks/African Americans accounted for 23.5%, Hispanics/Latinos 12.4%, and Asians accounted for 9.0%. The median age at disease onset was 38.4 years, with a median ARR of 0.5. Seropositive cases were older at disease onset, more likely to be black/African American or Hispanic/Latino, and more likely to be female. Conclusions Collectively, the CIRCLES experience to date demonstrates this study to be a useful and readily accessible resource to facilitate accelerating solutions for patients with NMOSD