Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality

Daiji Kiyozumi, Yukimasa Taniguchi, Itsuko Nakano, Junko Toga, Emiko Yagi, Hidetoshi Hasuwa, Masahito Ikawa, and Kiyotoshi Sekiguchi, "Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality", Life Science Alliance, Vol.1, No.5, e201800064, Life Science Alliance, 201

Evaluación de factibilidad económica y financiera para la importación y comercialización de llantas para vehículos de tres ruedas - 2016

RESUMEN La presente tesis en proyectos de inversión trata del estudio de rentabilidad de la importación y comercialización de llantas para vehículos de tres ruedas en nuestro mercado conocidos como MOTOTAXI especialmente de la marca Bajaj. Contactamos con un fabricante de llantas de la India quien llego a Lima ofreciendo sus productos y en el abanico de su oferta pudimos identificar las llantas para mototaxi, cerramos el negocio por la compra de un contenedor de 20 pies (2 250 llantas) del tamaño 4.00-8. La empresa fue constituida el 29 de septiembre del 2016 con el nombre de JRM TYRES SAC con número de RUC 20601541000 el capital inicial fue de S/. 87 340.00 obtenido a través de un prestamos en el Banco de Crédito del Perú con una TEA de 8.5 %, los socios accionistas son 3 quienes comparten todos los gastos relacionados al proyecto. La demanda en Lima Metropolitana es el 50 % del mercado total en el Perú la diferencia se encuentra distribuida en los demás departamentos del país. No existe una ley que reglamente el servicio que los mototaxis realizan, son las municipales que a través de ordenanzas reglamentan el servicio y la cantidad de estos vehículos. Nuestro producto, no se comercializa en Lima, pero si existen varias marcas que han ingresado al mercado, una de las debilidades es que aún no conocemos exactamente sus cualidades de rendimiento, pero según la información del fabricante estaríamos compitiendo con la llanta mejor posicionada en el mercado local (MRF). Se ha realizado el estudio de rentabilidad del proyecto, dando como resultados la viabilidad del proyecto de inversión, con la meta inicial de importar 4 contenedores de 20 ft por año y comercializar cada contenedor en 3 meses. Para nuestro segundo año esperamos tener posicionada nuestra marca e iniciar actividades en otros rubros, ya que el fabricante tiene un gran abanico de productos.ABSTRACT The present thesis in investment projects is about the studying of the economic profitability of import and selling tyres to three wheeler vehicles in our market, knowing as “mototaxi”, mainly Bajaj brand. We did contact with one maker of this type of tyres from India who arrived to Lima offering his products and we can found the three wheeler tyres is their product catalog, we close a business for the purchase of one (20 feet) container (2 250 units) of 4.00 – 8 tyres. The business was establish in September 29th, 2016 under the name of JRM TYRES SAC, with RUC number 20601541000, our initial capital was S/. 127 340 obtained by bank loan in the Bank of Credit of Peru (BCP) with an interest of TEA of 8.5 %, the shareholder partners are three people whom they face all the expenses of the project. The demand in Lima area is 50% of the global market in Peru, the other 50% is located around the others departments of Peru. There is not a law that regulates the service of the mototaxis do; however the municipalities through ordinances are regulate the services and the quantity of these vehicles in each district. Our product is not selling in Lima under the same name and brand, but there are many brands that are entry at the local market. One of our weaknesses is that we do not know exactly their qualities of the performance but according to the manufacturer the tyres are as same as the best tyres in our market (MRF). We did the studies of the cost effectiveness of our project, and the results are positives, with the target of import four containers per year and sell it every three months. For our second year we will hope to have our brand positioned and start other activities of selling different kinds of tyres in other areas, because the manufacturer has a good variety of products

Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome–associated proteins

Dysfunction of the basement membrane protein QBRICK provokes Fraser syndrome, which results in renal dysmorphogenesis, cryptophthalmos, syndactyly, and dystrophic epidermolysis bullosa through unknown mechanisms. Here, we show that integrin α8β1 binding to basement membranes was significantly impaired in Qbrick-null mice. This impaired integrin α8β1 binding was not a direct consequence of the loss of QBRICK, which itself is a ligand of integrin α8β1, because knock-in mice with a mutation in the integrin-binding site of QBRICK developed normally and do not exhibit any defects in integrin α8β1 binding. Instead, the loss of QBRICK significantly diminished the expression of nephronectin, an integrin α8β1 ligand necessary for renal development. In vivo, nephronectin associated with QBRICK and localized at the sublamina densa region, where QBRICK was also located. Collectively, these findings indicate that QBRICK facilitates the integrin α8β1–dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome.©2012 Kiyozumi et al. Originally published in the Journal of Cell Biology. https://doi.org/10.1083/jcb.20120306

Effects of Volunteering at Welfare Facilities in Japanese Senior Citizens on Their Own Well-being

Although volunteering has attracted attention in Japan as a useful measure for evaluating the level of senior citizens\u27self-rated health and satisfaction, no study has focused on the benefits of volunteering by Japanese senior citizens. To elucidate the effects of volunteering by Japanese women on their own well-being, we collected data from 106 volunteers and 60 non-volunteers aged 60 years or over using a self-administered questionnaire that included questions about sociodemographic characteristics, physical conditions, self-rated health, meaning and satisfaction in life, and emotional support network. Significant differences were observed between the volunteer group and the non-volunteer group in "self-rated health," "frequency of consulting doctors," and "frequency of communicating with friends." Also, total score of "source of meaning and satisfaction in life" and total score of "emotional support network" were significantly higher in the volunteer group than in the non-volunteer group. After adjusting for the effects of other factors, "frequency of consulting doctors" and "emotional support network" remained significantly associated with the frequency of being a voluntary worker. The present study suggests that volunteering might partially contribute to improving the well-being of senior citizens. Further studies are needed to clarify the effects of volunteering on the well-being of senior citizens in an aging society

Effects of Volunteering at Welfare Facilities in Japanese Senior Citizens on Their Own Well-being

Although volunteering has attracted attention in Japan as a useful measure for evaluating the level of senior citizens'self-rated health and satisfaction, no study has focused on the benefits of volunteering by Japanese senior citizens. To elucidate the effects of volunteering by Japanese women on their own well-being, we collected data from 106 volunteers and 60 non-volunteers aged 60 years or over using a self-administered questionnaire that included questions about sociodemographic characteristics, physical conditions, self-rated health, meaning and satisfaction in life, and emotional support network. Significant differences were observed between the volunteer group and the non-volunteer group in "self-rated health," "frequency of consulting doctors," and "frequency of communicating with friends." Also, total score of "source of meaning and satisfaction in life" and total score of "emotional support network" were significantly higher in the volunteer group than in the non-volunteer group. After adjusting for the effects of other factors, "frequency of consulting doctors" and "emotional support network" remained significantly associated with the frequency of being a voluntary worker. The present study suggests that volunteering might partially contribute to improving the well-being of senior citizens. Further studies are needed to clarify the effects of volunteering on the well-being of senior citizens in an aging society

Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality

Daiji Kiyozumi, Yukimasa Taniguchi, Itsuko Nakano, Junko Toga, Emiko Yagi, Hidetoshi Hasuwa, Masahito Ikawa, and Kiyotoshi Sekiguchi, "Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality", Life Science Alliance, Vol.1, No.5, e201800064, Life Science Alliance, 201