Development the interactive tonality blending system and artworks

The definition of "tonality" includes two meanings on artistic field. In the visual area, it means the system of tones or tints, or the color scheme, of a picture. In the meantime, it means the musical system of the relations of pitch, scale, chord and their progressions. In general, both definitions are expanded as the word that means the quality of visual, auditory perception. This artwork is the trial for assembling visual and auditory "tonality" in an interactive system

Development the interactive tonality blending system and artworks

The definition of "tonality" includes two meanings on artistic field. In the visual area, it means the system of tones or tints, or the color scheme, of a picture. In the meantime, it means the musical system of the relations of pitch, scale, chord and their progressions. In general, both definitions are expanded as the word that means the quality of visual, auditory perception. This artwork is the trial for assembling visual and auditory "tonality" in an interactive system

PreBI: prediction of biological interfaces of proteins in crystals

PreBI is a server that predicts biological interfaces in protein crystal structures, according to the complementarity and the area of the interface. The server accepts a coordinate file in the PDB format, and all of the possible interfaces are generated automatically, according to the symmetry operations given in the coordinate file. For all of the interfaces generated, the complementarities of the electrostatic potential, hydrophobicity and shape of the interfaces are analyzed, and the most probable biological interface is identified according to the combination of the degree of complementarity derived from the database analyses and the area of the interface. The results can be checked through an interactive viewer, and the most probable complex can be downloaded as atomic coordinates in the PDB format. PreBI is available at

Usefulness of acute pulmonary vasoreactivity test of sildenafil in treatment of portopulmonary hypertension. A case report

SummaryA 50-year-old man diagnosed with liver cirrhosis type C was referred to our hospital because of right heart failure with pulmonary hypertension. Echocardiography revealed enlargement of the right atrium and ventricle with severe tricuspid regurgitation. The peak flow velocity of tricuspid regurgitation by continuous wave Doppler echocardiography was 452cm/s. Right heart catheterization demonstrated severe pulmonary hypertension [pulmonary arterial pressure (PAP) systolic/diastolic/mean=73/20/41mmHg and pulmonary vascular resistance (PVR)=509dynscm–5] with portal hypertension. We diagnosed the patient as having portopulmonary hypertension (PoPH). Although we treated the patient with a prostacyclin analog, tricuspid regurgitation velocity was increased to 480cm/s four years after the start of the therapy. To select drugs for the treatment of PoPH, we performed an acute vasoreactivity test of sildenafil during right heart catheterization. Since single administration of sildenafil (20mg) decreased PAP (93/30/55–77/27/44mmHg) and PVR (908–833dynscm–5), we added sildenafil (20mg, t.i.d.) to the prostacyclin analog. Tricuspid regurgitation velocity decreased to 403cm/s one year after the addition of sildenafil. An acute vasoreactivity test of sildenafil during right heart catheterization was useful for the decision of the drug to be used in the treatment of PoPH