Sex Differences in the Footprint Analysis During the Entire Gait Cycle in a Functional Equinus Condition: Novel Cross Sectional Research

Some studies suggest that gender is related to gait. Females show significantly higher ankle motion and vertical ground reaction forces. Males have significantly larger plantar contact surface areas in all regions of the foot than females in most, but not all, prior studies. However, there is no research on sex differences in a functional equinus condition. In this study, 119 individuals, including 59 females (29.7 ± 5.15 years, 58.74 ± 6.66 kg, 163.65 ± 5.58 cm) and 60 males (31.22 ± 6.06 years, 75.67 ± 9.81 kg, 177.10 ± 6.16 cm), with a functional equinus condition walked onto a pressure platform. In two separate testing sessions, five trials of each foot were conducted for the first, second, and third steps. We measured the contact surface areas for each of the three phases of the stance phase. We computed the intraclass correlation coefficient and standard error of the mean to assess the reliability. We found significantly greater contact surface areas in males than females in the first, second, and third steps in all phases of the stance phase: heel strike, mid-stance, and take-off. This is important information for the design of footwear and orthotics and gender knowledge. In a functional equinus condition, males have registered greater contact surface areas than females in all phases of the dynamic footprint of the stance phase

Reseña del primer congreso virtual internacional “Educación inclusiva en la infancia”

El primer congreso internacional virtual “Educación Inclusiva en la Infancia” se desarrolló en la plataforma Zoom del 27 al 29 de julio de 2021 de16:00 a 19:00 hora del centro de México, la organización fue realizada por la Universidad de San Sebastián de la Ciudad de México y el Centro Internacional de Alta Tecnología para la Audición y el Lenguaje A. C. de la Ciudad de Puebla con la invitación de ponentes de los países de Argentina, Chile, Colombia y México.   La congregación se dirigió a docentes en proceso de formación, docentes en ejercicio, terapeutas, investigadores, padres de familia e interesados en el tema con el propósito de compartir experiencias pedagógicas y socioemocionales alrededor de la infancia y la educación inclusiva desde diversos contextos. Al congreso asistieron un promedio de 320 personas por día. Hubo asistentes de varios estados de la República Mexicana, así como de los países de Argentina, Colombia, Perú, Guatemala, Chile, Paraguay, El Salvador, Brasil y Bolivia. Lo anterior denota el interés en la temática central propuesta en el congreso “La educación inclusiva”. &nbsp

Energía eléctrica generada por magnetismo para el uso en un gimnasio

Tesina (Técnico en Máquinas con sistemas automatizados). Ciudad de México, Instituto Politécnico Nacional, Centro de Estudios Científicos y Tecnológicos 09 "Juan de Dios Bátiz". 2017. 1 archivo PDF, (78 páginas). tesis.ipn.m

Low Expression of IL-10 in Circulating Bregs and Inverted IL-10/TNF-α Ratio in Tears of Patients with Perennial Allergic Conjunctivitis: A Preliminary Study

Allergic conjunctivitis (AC) is one of the most common ophthalmological disorders seen in clinical practice. Growing evidence from recent years suggests that a subset of IL-10-expressing B cells is involved in inflammatory allergic diseases. In this study, we aimed to evaluate the potential involvement of blood Bregs cells in perennial allergic conjunctivitis (PAC), and interleukins (IL)-1β, IL-6, IL-8, IL-10, and IL-12, and tumor necrosis factor (TNF)-α, were measured in tear samples and compared with healthy controls (HC) using flow cytometry. Non-significant differences in CD19+IL-10+ cell frequency between PAC patients and healthy controls (HC) were observed. Nevertheless, when we analyzed the mean fluorescence intensity (MFI) of IL-10 on CD19+CD38Lo/Med/Hi-gated cells, we observed a significant decrease in MFI in all Bregs subsets in PAC patients. Additionally, tear cytokines showed 2.8 times lower levels of IL-10 than TNF-α in PAC patients when compared to HC. Our findings demonstrate an immunological dysregulation in patients with allergic conjunctivitis, characterized by the low expression of IL-10 in circulating CD19+CD38+ Bregs subsets and an inverted tear IL-10/TNF-α ratio, promoting a local pro-inflammatory microenvironment. These findings highlight the novel pathologic changes involved in ocular allergic diseases. Understanding systemic and local mechanisms will aid the design of immunomodulating therapeutics at different levels

Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies

Human African Trypanosomiasis (HAT), a disease that provokes 2184 new cases a year in Sub-Saharan Africa, is caused by Trypanosoma brucei. Current treatments are limited, highly toxic, and parasite strains resistant to them are emerging. Therefore, there is an urgency to find new drugs against HAT. In this context, T. brucei depends on glycolysis as the unique source for ATP supply; therefore, the enzyme triosephosphate isomerase (TIM) is an attractive target for drug design. In the present work, three new benzimidazole derivatives were found as TbTIM inactivators (compounds 1, 2 and 3) with an I50 value of 84, 82 and 73 µM, respectively. Kinetic analyses indicated that the three molecules were selective when tested against human TIM (HsTIM) activity. Additionally, to study their binding mode in TbTIM, we performed a 100 ns molecular dynamics simulation of TbTIM-inactivator complexes. Simulations showed that the binding of compounds disturbs the structure of the protein, affecting the conformations of important domains such as loop 6 and loop 8. In addition, the physicochemical and drug-like parameters showed by the three compounds suggest a good oral absorption. In conclusion, these molecules will serve as a guide to design more potent inactivators that could be used to obtain new drugs against HAT

Identification of extensive drug resistant Pseudomonas aeruginosa strains: New clone ST1725 and high-risk clone ST233.

Several microorganisms produce nosocomial infections (NIs), among which Pseudomonas aeruginosa stands out as an opportunist pathogen with the capacity to develop multiresistance to first-choice antibiotics. From 2007 to 2013, forty-six NIs produced by P. aeruginosa were detected at a pediatric tertiary care hospital in Mexico with a significant mortality rate (17.39%). All isolates (n = 58/46 patients) were characterized by evaluating their response to several antibiotics as panresistant (PDR), extensively resistant (XDR), multiresistant (MDR) or sensitive (S). In addition, all isolates were typified through multilocus sequencing of seven genes: acsA, aroE, guaA, mutL, nuoD, ppsA and trpE. Furthermore, to establish the genetic relationships among these isolates, we carried out a phylogenetic inference analysis using maximum likelihood to construct a phylogenetic network. To assess evolutionary parameters, recombination was evaluated using the PHI test, and the ratio of nonsynonymous to synonymous substitutions was determined. Two of the strains were PDR (ST1725); 42 were XDR; four were MDR; and ten were S. Twenty-one new sequence types were detected. Thirty-three strains exhibited novel sequence type ST1725. The ratio of nonsynonym to synonym substitutions was 1:1 considering all genes. Phylogenetic analysis showed that the genetic relationship of the PDR, XDR and MDR strains was mainly clonal; however, the PHI test and the phylogenetic network suggest that recombination events occurred to produce a non-clonal population. This study aimed not only to determine the genetic diversity of clinical P. aeruginosa but also to provide a warning regarding the identification and spreading of clone ST1725, its ability to cause outbreaks with high mortality rates, and to remain in the hospital environment for over seven years. These characteristics highlight the need to identify clonal outbreaks, especially where high resistance to most antibiotics is observed, and control measures are needed. This study also represents the first report of the PDR ST1725