The importance of Cone-Beam computed tomography in diagnosis of associated mandibular osteonecrosis: case report / A importância da TCFC no diagnóstico e prognóstico da osteonecrose mandibular associada aos bisfosfonatos: relato de caso clínico

The Cone-Beam Computed Tomography (CBCT) is very useful in diagnosis and treatment planning, as well as in the prognosis of osteonecrosis of the jaws. This study reports a clinical case of Bisphosphonate-Associated Mandibular Osteonecrosis from the perspective of CBCT. The patient, female, 83 years old, presented painful symptoms in the posterior region of the right mandible and reported Bisphosphonate medication for more than five years to treat osteoporosis and osteopenia. Based on clinical and CBCT imaging characteristics, the patient was diagnosed with Bisphosphonate-Associated Mandibular Osteonecrosis. Initially, the treatment consisted of oral antibiotic therapy, pain control, hyperbaric oxygenation and oral hygiene (mouthwashes). After 11 months of clinical therapy, CBCT revealed bone reconstruction of the buccal cortex, but also a hypodense imaging in the lingual cortex compatible with bone lysis and bone sequestration. The patient was referred for bone debridement and sequestrectomy. The histopathological diagnosis consisted of osteonecrosis with secondary acute osteomyelitis. After 60 days of the surgical procedure and hyperbaric sessions/systemic antibiotic therapy, an oral healthy mucosa in the region of the right mandibular body was evidenced in the intraoral examination. Cortical bone regeneration was observed on CBCT. Concluded that the use of CBCT, in this case report, makes it possible to estimate the extent of the lesion and the post-treatment outcome, assessing bone density, the presence of bone sequestration and the involvement of the involved areas. In fact, early diagnosis is essential for the success of the therapeutic approach

Pré-molares inclusos e anquilosados: diagnóstico pela tomografia computadorizada do feixe cônico

Early diagnosis of dental eruption anomalies using cone beam computed tomography (CBCT) provides accurate information that leads to orthodontic and/or surgical treatment with a favorable prognosis. The present study proposes to describe tooth ankylosis associated with unerupted premolars in 04 cone beam computed tomography images. Five lower premolars included with a related ankylosis process were analyzed. In CBCT, the acquisition of the best image sharpness and contrast must always be linked to the specific purpose of the diagnosis to generate greater confidence in the interpretation of anatomical structures and pathological processes.O diagnóstico precoce das anomalias de erupção dentárias pela tomografia computadorizada de feixe cônico (TCFC) possibilita informações precisas que conduzem a um tratamento ortodôntico e/ou cirúrgico com prognóstico favorável. O presente estudo propõe descrever anquilose dentária associada à pré-molares não irrompidos em 04 imagens de tomografias computadorizadas de feixe cônico. Foram analisados 05 pré-molares inferiores inclusos com processo de anquilose relacionado. Na TCFC, a aquisição da melhor nitidez e contraste da imagem deve estar sempre atrelada ao fim específico do diagnóstico para gerar maior segurança na interpretação das estruturas anatômicas e processos patológicos

Tomografia computadorizada como instrumento para diagnóstico precoce de ameloblastoma na infância: relato de caso: Computerized tomography as a tool for early diagnosis of ameloblastoma in childhood: case report

Introdução: A tomografia computadorizada de feixe cônico (TCFC) auxilia a investigação de processos patológicos na Odontopediatria, sendo fundamental na estratégia do tratamento cirúrgico. Objetivo: Relatar o caso clínico de uma criança com ameloblastoma abordando o uso da TCFC no diagnóstico e plano de tratamento. Relato de caso: Trata-se do relato do caso clínico de uma paciente de 11 anos de idade diagnosticada com ameloblastoma. A criança foi encaminhada para a equipe de Cirurgia e Traumatologia Bucomaxilofacial das Obras Sociais Irmã Dulce, com dor e edema no lado esquerdo da face. Ao exame intraoral, observou-se dentição mista com higiene bucal satisfatória, bem como oclusão dentária classe I. A radiografia panorâmica evidenciou a presença de imagem radiolúcida com margens bem definidas, unilocular, associada a coroa do dente 37, com deslocamento dessa unidade em direção ao 36. Além disso, foi possível perceber o deslocamento da unidade 38 para a incisura mandibular. Na análise da TCFC, observou-se a expansão das corticais ósseas com afilamento e perfuração, evidenciando o caráter agressivo da lesão de extensão 30,0 x 26,0 x 57,85 mm. O diagnóstico de ameloblastoma do tipo plexiforme foi elucidado pelo exame anatomopatológico. Conclusão: A partir dessa análise proporcionada pela tomografia, foi possível constatar o caráter agressivo da lesão e o comprometimento dos tecidos ósseos circundantes e dentes adjacentes, orientando com precisão o plano de tratamento cirúrgico. O diagnóstico precoce e o conhecimento sobre a extensão das lesões são importantes para que haja um tratamento adequado e melhor prognóstico

Aspectos tomográficos pelo feixe cônico de impactação dentária com hipercementose: série de 4 casos

The early diagnosis of dental eruption and developmental anomalies through cone beam computed tomography (CBCT) enables dentists to obtain precise information leading to therapeutic interventions with favorable prognosis. This study aimed to describe the diagnosis using CBCT of hypercementosis associated with impacted teeth. An observational study was realized on 4 tomographic images from the database of a radiographic documentation institute of Brazilian adolescents and adults, both female, showing generalized hyperdense images involving root thirds of impacted teeth, compatible with hypercementosis. The analyzed images revealed the location of the impacted teeth and their hypercementosis process, as well as the presence or absence of their pericementary space and the possibility of external root resorption of adjacent teeth. It was concluded that CBCT allows for better clarity and contrast of the three-dimensional image of impacted teeth with ankylosis, enabling precise diagnosis with greater safety in interpreting anatomical structures for appropriate surgical intervention.O diagnóstico precoce das anomalias dentárias de erupção e de desenvolvimento pela tomografia computadorizada de feixe cônico (TCFC) possibilita ao cirurgião dentista informações precisas que conduzem a uma intervenção terapêutica com prognóstico favorável. O presente estudo se propôs a descrever o diagnóstico com o auxílio da TCFC de hipercementose associada à impactação dentária. Foi realizado um estudo observacional em 4 imagens tomográficas do arquivo de um instituto de documentação radiográfica de adolescentes e adultos brasileiros, ambos do sexo feminino, que apresentavam imagens hiperdensas generalizadas envolvendo terços radiculares de unidades dentárias impactadas, compatíveis com hipercementose. As imagens analisadas revelaram a localização das unidades dentárias comprometidas e do seu processo de hipercementose, assim como a presença ou não do seu espaço pericementário e a possibilidade de reabsorção radicular externa dos dentes adjacentes. Concluiu-se que a TCFC permite melhor nitidez e contraste da imagem tridimensional dos dentes impactados com processo de anquilose permitindo diagnóstico preciso com maior segurança na interpretação das estruturas anatômicas para uma intervenção cirúrgica adequada

Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors

Rocha, Clarissa Araujo Gurgel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-04-20T12:51:25Z No. of bitstreams: 1 Ismerim AB Insulin-like....pdf: 324349 bytes, checksum: 0e7d4fd31ab9308c6d6984f11f980446 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-04-20T13:10:12Z (GMT) No. of bitstreams: 1 Ismerim AB Insulin-like....pdf: 324349 bytes, checksum: 0e7d4fd31ab9308c6d6984f11f980446 (MD5)Made available in DSpace on 2018-04-20T13:10:12Z (GMT). No. of bitstreams: 1 Ismerim AB Insulin-like....pdf: 324349 bytes, checksum: 0e7d4fd31ab9308c6d6984f11f980446 (MD5) Previous issue date: 2016CNPq and FAPESB for financial support and scholarshipsFederal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, BrasilA.C. Camargo Center Cancer, São Paulo, SP, BrasilA.C. Camargo Center Cancer, São Paulo, SP, BrasilFederal University of Bahia. Institute of Health Sciences. Department of Biomorphology. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, BrasilInsulin-like growth factor II mRNA-binding protein 3 (IMP3) is strongly expressed in malignant tumors and has been associated with their aggressive behavior. The aim of this study was to evaluate the presence of IMP3 in a series of salivary gland tumors. The sample consisted of 9 pleomorphic adenomas (PA), 14 adenoid cystic carcinomas (ACC), and 13 mucoepidermoid carcinomas (MEC) that were investigated by immunohistochemical technique. All cases of PA and MEC were positive for IMP3 particularly in the cytoplasm. PA showed 4 cases as high expression and 6 as low expression. MEC showed 10 cases as low expression and 3 as high expression. For ACC, 4 cases were high expression, whereas 6 cases were low expression. No significant difference was observed between tumors (P>0.05, Fisher’s test) when both scores of IMP3 were compared. This study showed that MEC seems to be more sensitive to IMP3 than ACC and provided an insight into this protein in salivary gland tumors. Furthermore, although IMP3 is not a specific diagnostic marker to distinguish the tumors studied, it seems to mediate cell adhesion and migration in these tumors. Further studies should be performed to better understand the IMP3 biology in salivary gland tumors