Intensification in the content of methodic training a teacher of technological education

Experience of methodic training a teacher of technological education in the transition to Federal state educational standards of general education on the bases of intensification of educational process by planning and arranging professionally oriented public projects is generalized in this article. © IDOSI Publications, 2013

Superconductivity on the localization threshold and magnetic-field-tuned superconductor-insulator transition in TiN films

Temperature- and magnetic-field dependent measurements of the resistance of ultrathin superconducting TiN films are presented. The analysis of the temperature dependence of the zero field resistance indicates an underlying insulating behavior, when the contribution of Aslamasov-Larkin fluctuations is taken into account. This demonstrates the possibility of coexistence of the superconducting and insulating phases and of a direct transition from the one to the other. The scaling behavior of magnetic field data is in accordance with a superconductor-insulator transition (SIT) driven by quantum phase fluctuations in two-dimensional superconductor. The temperature dependence of the isomagnetic resistance data on the high-field side of the SIT has been analyzed and the presence of an insulating phase was confirmed. A transition from the insulating to a metallic phase is found at high magnetic fields, where the zero-temperature asymptotic value of the resistance being equal to h/e^2.Comment: 5 pages, 4 eps figures, RevTeX4, Published versio

5-Amino-Substituted Derivatives of 4-Nitrofurazane: Synthesis, Structure, and Biological Activity

© 2018, Pleiades Publishing, Ltd. New amination reactions of 5-chloro-4-nitrobenzofurazane with different amines were studied. The reactions of 5-chloro-4-nitrobenzofurazane with 2,4,6-trichloro-, para-acetyl-, and para-carboxyethylanilines gave the products of aromatic nucleophilic substitution of the chlorine substituent in the nitrogenous heterocycle, the composition and structure of which was established by chemical, physical, and physicochemical methods and X-ray diffraction analysis. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG‒DSC). The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora

Immunohistochemical research of reaction of motoneurons of lumbar spinal cord of the mice that were in 30-day flight on the BION-M1 biosatellite on a week readaptation to conditions of Earth gravitation

© 2016, Human Stem Cell Institute. All rights reserved.Earlier, by an immunohistochemical method we define that after 30-day space flight in motoneurons of mice lumbar spinal cord immunoexpression of the proteins responsible for synaptic transfer of a nervous impulse and proteins of heat shock proteins decrease. In this research for an assessment of animals recovery process dynamics after space flight we studied an immunoexpression of the proteins participating in synaptic transfer of a nervous impulse (synaptophisyne, and PSD95), neurotrophic factors (a vascular endothelial factor of growth - VEGF and its receptor - Flt-1) and heat shock proteins (Hsp25 and Hsp70) in motoneurons of lumbar spinal cord of a mice after 30-day space flight on the BION-M1 biosatellite and the subsequent week readaptation to conditions of Earth gravitation. In this research by immunohistochemical method determine that after a week of animals staying in the Earth gravitation conditions the immunoexpression of synaptophisyne continued to decrease while the expression of PSD95, Hsp25, Hsp70 and VEGF increased in relation to the animals removed from experiment right after 30-day flight. The obtained data confirm functional plasticity of spinal cord motoneurons in the conditions of gravitation force changing. The fact, which is especially interesting, that "switches on" of neurons protective mechanisms (strengthening of heat shock proteins and neurotrophic factor expression) happens not in response to hypogravitation influence, but only a week after return of animals to conditions of Earth gravitation

The structure of 1-phenyl-3-benzoylamino-4-benzoylpyrazol-2-in-5-one

Crystal and molecular structure of 1-phenyl-3-benzoylamino-4-benzoylpyrazol-2-in-5-one as a product of the benzoylation of 1-phenyl-3-benzoylaminopyrazol-2-in-5-one was characterised by X-ray single crystal diffraction. It is shown that 1-phenyl-3-benzoylamino-4-benzoylpyrazol-2-in-5-one exists in the solid phase in an NH-tautomeric form, which is stabilised by two intramolecular hydrogen bonds and one intermolecular bond with the solvate dioxane molecule, the latter being used as a solvent for recrystallisation. © 2002 Elsevier Science B.V. All rights reserved

University educational district as an innovative corporation and education management entity

© 2016, Econjournals. All rights reserved.Relevance of the paper is caused by the regionalization of education and the development of organizational and managerial innovations in the education system. The aim of the article is to reveal features of the University educational district as an innovative Corporation and the entity of education management. The leading method is the method of action research, allowing to obtain new knowledge about University educational district, as innovative Corporation and the entity of education management and to develop a mechanism for the formation of regional educational environment. The article reveals the essence of the University educational district as an open and accountable social institution for society; determines the content of the regional educational environment, providing an efficient interaction of all the entities of educational policy in the region; represents a mechanism of formation of the regional educational environment aimed at sustainable development of the region. Article submissions may be useful for research and teaching staff of vocational educational system, specialists of education authorities and regional authorities

Construction of recombinant adenovirus containing picorna-viral 2A-peptide sequence for the co-expression of neuro-protective growth factors in human umbilical cord blood cells

© 2015 International Spinal Cord Society Study design:Experimental study.Objective:Several neuro-degenerative disorders such as Alzheimer’s dementia, Parkinson’s disease and amyotrophic lateral sclerosis (ALS) are associated with genetic mutations, and replacing or disrupting defective sequences might offer therapeutic benefits. Single gene delivery has so far failed to achieve significant clinical improvements in humans, leading to the advent of co-expression of multiple therapeutic genes. Co-transfection using two or more individual constructs might inadvertently result in disproportionate delivery of the products into the cells. To prevent this, and in order to rule out interference among the many promoters with varying strength, expressing multiple proteins in equimolar amounts can be achieved by linking open reading frames under the control of only one promoter.Setting:Kazan, Russian Federation.Methods:Here we describe a strategy for adeno-viral co-expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) interconnected through picorna-viral 2A-amino-acid sequence in transfected human umbilical cord blood mono-nuclear cells (hUCB-MCs).Results:Presence of both growth factors, as well as absence of immune response to 2A-antigen, was demonstrated after 28–52 days. Following injection of hUCB-MCs into ALS transgenic mice, co-expression of VEGF and FGF2, as well as viable xeno-transplanted cells, were observed in the spinal cord after 1 month.Conclusion:These results suggest that recombinant adeno-virus containing 2A-sequences could serve as a promising alternative in regenerative medicine for the delivery of therapeutic molecules to treat neurodegenerative diseases, such as ALS.Spinal Cord advance online publication, 6 October 2015; doi:10.1038/sc.2015.162

The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries

DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt

Intensification in the content of methodic training a teacher of technological education

Experience of methodic training a teacher of technological education in the transition to Federal state educational standards of general education on the bases of intensification of educational process by planning and arranging professionally oriented public projects is generalized in this article. © IDOSI Publications, 2013