1,495 research outputs found
The biological activity of soluble antigen-antibody complexes: II. Physical properties of soluble complexes having skin-irritating activity
Previous work by Germuth and McKinnon (1), Trapani et al. (2), and ourselves (3) has established the fact that soluble antigen-antibody complexes formed in excess antigen can, (a) induce symptoms similar to anaphylaxis, (b) cause contraction of isolated smooth muscle from normal guinea pigs, and (c) increase the permeability of skin capillaries in a manner similar to that obtained in passive cutaneous anaphylaxis. These findings immediately raise many questions as to the fundamental mechanisms involved. For example, is the free antigen playing some role; is the toxicity dependent upon some change in the molecular structure of either antigen or antibody upon combination; is the complex itself toxic without any change in the molecular structure of the components; is the antigen-antibody ratio important; and, is complement involved? The work reported here involves a study of the possible role of free antigen and the nature of the complex. Some study was also made of untreated and decomplemented antiserums and, although there was no difference, this cannot rule out the possible participation of the test animal's (guinea pig's) own complement
Observation of Jonscher Law in AC Hopping Conduction of Electron-Doped Nanoporous Crystal 12CaO7Al2O3 in THz Frequency Range
We have performed terahertz time-domain spectroscopy of carrier-doped
nanoporous crystal 12CaO7Al2O3 showing the Mott variable range hopping at room
temperature. The real part of the dielectric constant clearly demonstrates the
nature of localized carriers. The frequency dependence of both the real and
imaginary parts of the dielectric constant can be simply explained by assuming
two contributions: a dielectric response by the parent compound with no
carriers and an AC hopping conduction with the Jonscher law generally reported
up to GHz range. The possible obedience to the Jonscher law in the THz range
suggests a relaxation time of the hopping carriers much faster than 1ps in the
carrier-doped 12CaO7Al2O3.Comment: 4pages 3figures. to be published in Phys. Rev.
Influence of aluminum oxide film on thermocompression bonding of gold wire to evaporated aluminum film
The influence of Al surface condition on the thermocompression bonding of Au wires to Al electrodes for integrated electric circuits was studied. Au wires were connected to Al electrodes by nail-head bonding after various Al surface treatments. Bonding was evaluated by measuring the wire pull strength and fraction of the number of failures at Au-Al bonds to the total number of failures. Dependence of the fraction on applied load was derived theoretically with a parameter named critical load to take into consideration the differences in Al surface condition. The relation also held explicately for various surface treatments. Characterization of the Al surface was carried out by electron microscopy for chemical analysis
Glucose-sulfate conjugates as a new phase II metabolite formed by aquatic crustaceans
ArticleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 360(2): 490-495 (2007)journal articl
Non-Thermal Emission from Relativistic Electrons in Clusters of Galaxies: A Merger Shock Acceleration Model
We have investigated evolution of non-thermal emission from relativistic
electrons accelerated at around the shock fronts during merger of clusters of
galaxies. We estimate synchrotron radio emission and inverse Compton scattering
of cosmic microwave background photons from extreme ultraviolet (EUV) to hard
X-ray range. The hard X-ray emission is most luminous in the later stage of
merger. Both hard X-ray and radio emissions are luminous only while signatures
of merging events are clearly seen in thermal intracluster medium (ICM). On the
other hand, EUV radiation is still luminous after the system has relaxed.
Propagation of shock waves and bulk-flow motion of ICM play crucial roles to
extend radio halos. In the contracting phase, radio halos are located at the
hot region of ICM, or between two substructures. In the expanding phase, on the
other hand, radio halos are located between two ICM hot regions and shows
rather diffuse distribution.Comment: 19 pages, 5 figures, accepted for publication in Ap
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Mast cell clones: a model for the analysis of cellular maturation.
Cloned mouse mast cells resemble, by ultrastructure, immature mast cells observed in vivo. These mast cell clones can be grown in the absence of any other cells, facilitating direct investigations of their biochemistry and function. We find that cloned mast cells express plasma membrane receptors (Fc epsilon R) that bind mouse IgE with an equilibrium constant (KA) similar to that of normal mouse peritoneal mast cells. In addition, cloned mast cells do not display detectable la antigens and cannot enhance lg secretion when added to lymphocyte cultures or mediate natural killer lysis. In the presence of 1 mM sodium butyrate, cloned mast cells stop dividing and acquire abundant electron-dense cytoplasmic granules similar to those of mature mast cells. Their histamine content increases concomitant with cytoplasmic granule maturation and may exceed that of untreated mast cells by 50-fold. Unlike peritoneal mast cells, cloned mast cells incorporate 35SO4 into chondroitin sulfates rather than heparin. These findings demonstrate that, unlike fully differentiated mouse peritoneal mast cells, cloned immature mouse mast cells contain no heparin and low levels of histamine. In addition, they establish that high-affinity Fc epsilon R are expressed early in mast cell maturation, well before completion of cytoplasmic granule synthesis and mediator storage
Development of the Shinshu University Online System of General Academic Resources (SOAR)
This paper discusses the development of the Shinshu University Online System of General Academic Resources (SOAR). As a participant in the 2006-2007 Cyber Science Infrastructure (CSI) development project of the National Institute of Informatics (NII), Shinshu University is seeking to develop SOAR as an integrated academic resource system. In addition to developing an environment for providing accesstothe latest academic resources within the university, SOAR is intended to promulgate university research results and research activities, both within Japan and around the world, to a broad audience. Specifically, this system achieves mutual coordination by linking e-journals and the Web of Science to the researcher directory and the institutional repository—two system cornerstones. SOAR can be regarded as a potential model for future academic-resource systems. Although the Institutional Repository (SOAR-IR) was developed using existing software, the Researcher Directory (SOARRD) is a new system based on XML technology.ArticleProgress in Informatics. 5:137-151 (2008)journal articl
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