Development of a Large-Area Aerogel Cherenkov Counter Onboard BESS

This paper describes the development of a threshold type aerogel Cherenkov counter with a large sensitive area of 0.6 m$^2$ to be carried onboard the BESS rigidity spectrometer to detect cosmic-ray antiprotons. The design incorporates a large diffusion box containing 46 finemesh photomultipliers, with special attention being paid to achieving good performance under a magnetic field and providing sufficient endurance while minimizing material usage. The refractive index of the aerogel was chosen to be 1.03. By utilizing the muons and protons accumulated during the cosmic-ray measurements at sea level, a rejection factor of 10$^4$ was obtained against muons with $\beta \approx 1$, while keeping 97% efficiency for protons below the threshold.Comment: 13 pages, LaTex, 9 eps figures included, submitted to NIM

Winding String Condensation and Noncommutative Deformation of Spacelike Singularity

In a previous paper (hep-th/0509067) using matrix model, we showed that closed string tachyons can resolve spacelike singularity in one particular class of Misner space (with anti-periodic boundary conditions for fermions around the spatial circle). In this note, we show that for Misner space without closed string tachyons, there also exists a mechanism to resolve the singularity in the context of the matrix model, namely cosmological winding string production. We show that here space and time also become noncommutative due to these winding strings. Employing optical theorem, we study the bulk boundary coupling by calculating the four-open-string cylinder amplitudes.Comment: 16 pages, no figures, harvmac; references added; added a section of discussion on disk and cylinder amplitude

FUCA1 is induced by wild-type p53 and expressed at different levels in thyroid cancers depending on p53 status

Fucose residues of cell surface glycans, which play important roles in growth, invasion and metastasis, are added by fucosyltransferases (FUTs) and removed by α-L-fucosidases (FUCAs). By the differential display method, we isolated a 3' non-coding region of α-L-fucosidase-1 (FUCA1) (a gene coding for the lysosomal fucosidase-1 enzyme) as a wild-type p53-inducible gene: 18S and 20S FUCA1 mRNA species were induced in Saos-2 cells transfected with a temperature-sensitive p53 mutant at the permissive temperature. By microarray analyses of thyroid cancer biopsy samples, FUCA1 RNA expression levels were found to be lower in anaplastic thyroid cancer samples (ATCs), while they were higher in papillary thyroid cancer samples (PTCs) and in normal thyroid tissues. Since most ATCs were reported to carry the mutated form of p53, while PTCs carry mostly the wild-type form of p53, it is likely that FUCA1 expression levels are regulated, at least in part, by the p53 status in thyroid cancers. In order to better understand the role played by FUCA genes in thyroid tumorigenesis, we examined the clonogenic potential in vitro of thyroid cell lines transfected with either FUCA1 or FUCA2 (the latter gene coding for a secreted, non-lysosomal enzyme). We found that α-L-fucosidases did not suppress grossly cell growth. Contrary to what we observed with the expression of FUCA1, the FUT8 expression levels were found high in ATCsbut lower in PTCs and normal thyroid tissues. Taken together, these results suggest the possibility that the higher fucose levels on cell surface glycans of aggressive ATCs, compared to those of less aggressive PTCs, may be at least in part responsible for the more aggressive and metastatic phenotype of ATCs compared to PTCs, as the expression levels of FUCA1 and FUT8 were inversely related in these two types of cancers. Fucose residues of cell surface glycans, which play important roles in growth, invasion and metastasis, are added by fucosyltransferases (FUTs) and removed by α-L-fucosidases (FUCAs). By the differential display method, we isolated a 3' non-coding region of α-L-fucosidase-1 (FUCA1) (a gene coding for the lysosomal fucosidase-1 enzyme) as a wild-type p53-inducible gene: 18S and 20S FUCA1 mRNA species were induced in Saos-2 cells transfected with a temperature-sensitive p53 mutant at the permissive temperature. By microarray analyses of thyroid cancer biopsy samples, FUCA1 RNA expression levels were found to be lower in anaplastic thyroid cancer samples (ATCs), while they were higher in papillary thyroid cancer samples (PTCs) and in normal thyroid tissues. Since most ATCs were reported to carry the mutated form of p53, while PTCs carry mostly the wild-type form of p53, it is likely that FUCA1 expression levels are regulated, at least in part, by the p53 status in thyroid cancers. In order to better understand the role played by FUCA genes in thyroid tumorigenesis, we examined the clonogenic potential in vitro of thyroid cell lines transfected with either FUCA1 or FUCA2 (the latter gene coding for a secreted, non-lysosomal enzyme). We found that α-L-fucosidases did not suppress grossly cell growth. Contrary to what we observed with the expression of FUCA1, the FUT8 expression levels were found high in ATCs but lower in PTCs and normal thyroid tissues. Taken together, these results suggest the possibility that the higher fucose levels on cell surface glycans of aggressive ATCs, compared to those of less aggressive PTCs, may be at least in part responsible for the more aggressive and metastatic phenotype of ATCs compared to PTCs, as the expression levels of FUCA1 and FUT8 were inversely related in these two types of cancers

Binary Quantum Turbulence Arising from Countersuperflow Instability in Two-Component Bose-Einstein Condensates

We theoretically study the development of quantum turbulence from two counter-propagating superfluids of miscible Bose-Einstein condensates by numerically solving the coupled Gross-Pitaevskii equations. When the relative velocity exceeds a critical value, the counter-superflow becomes unstable and quantized vortices are nucleated, which leads to isotropic quantum turbulence consisting of two superflows. It is shown that the binary turbulence can be realized experimentally in a trapped system.Comment: 5 pages, 3 figure

Development of a CMOS SOI pixel detector

We have developed a monolithic radiation pixel detector using silicon on insulator (SOI) with a commercial 0.15 m fullydepleted- SOI technology and a Czochralski high resistivity silicon substrate in place of a handle wafer. The SOI TEG (Test Element Group) chips with a size of 2.5 x 2.5mm2 consisting of 20 x 20 um2 pixels have been designed and manufactured. Performance tests with a laser light illumination and a . ray radioactive source indicate successful operation of the detector. We also brie y discuss the back gate effect as well as the simulation study

The Certification of ATLAS Thin Gap Chambers Produced in Israel and China

Thin gap chambers (TGCs) are used for the muon trigger system in the forward region of the LHC experiment ATLAS. A TGC consists of a plane of closely spaced wires maintained at positive high voltage, sandwiched between resistive grounded cathode planes with an anode wire to cathode plane gap distance smaller than the wire-to-wire spacing. The TGCs are expected to provide a trigger signal within 25 ns of the bunch spacing of the LHC accelerator, with an efficiency exceeding 95%, while exposed to an effective photon and neutron background ranging from 30 to 500 Hz/cm2. About 2,500 out of the 3,600 ATLAS TGCs are being produced at the Weizmann institute in Israel, and in Shandong University in China. Once installed in the ATLAS detector the TGCs will be inaccessible. A vigorous production quality control program is therefore implemented at the production sites. Furthermore, after chamber completion, a thorough program of quality assurance is implemented to ensure the efficient performance of the chambers during more than ten years of operation in the LHC high rate environment. This program consists of a detailed mapping of the detectors response using cosmic rays, as well as checking the chambers behavior using a high rate radiation source. An aging test performed on five chambers in a serial gas connection is presented. Finally the results of the chambers certification tests performed at CERN before the installation in ATLAS are described.Comment: Presented at 2004 IEEE Nuclear Science Symposium 2004, Rome, Oct 200

Experimental Signature of Medium Modifications for rho and omega Mesons in the 12 GeV p + A Reactions

The invariant mass spectra of e+e- pairs produced in 12-GeV proton-induced nuclear reactions are measured at the KEK Proton-Synchrotron. On the low-mass side of the omega meson peak, a significant enhancement over the known hadronic sources has been observed. The mass spectra, including the excess, are well reproduced by a model that takes into account the density dependence of the vector meson mass modification, as theoretically predicted.Comment: 4 pages, 3 figures, Version accepted for Physical Review Lette

Interstitial Superstructures in the Ta-D System(Chemistry)

Ordered deuterium arrangements and order-disorder transformations of the tantalum deuterides in the range TaD_-TaD_ have been studied by neutron diffraction and calorimetry at temperatures between -170 and 120℃. In addition to the disordered phase (α), three ordered phases based on the superstructures Ta_2D_(β_1), Ta_4D_3(γ), and TaD(δ) are clarified. The Ta_2D_ structure is a nonstoichiometric form of the Ta_2D superstructure over the range x changes to the disordered α-phase around 100℃