Suzaku X-Ray Observation of the Dwarf Nova Z Camelopardalis at the Onset of an Optical Outburst

We present the result of a Suzaku X-ray spectroscopic observation of the dwarf nova Z Camelopardalis, which was conducted by chance at the onset of an optical outburst. We used the X-ray Imaging Spectrometer (a 38 ks exposure) and the Hard X-ray Detector (34 ks) to obtain a 0.35-40 keV spectrum simultaneously. Spectral characteristics suggest that the source was in the X-ray quiescent state despite being in the rising phase of an outburst in the optical band. The spectrum shows a clear signature of circumstellar absorption in excess of interstellar absorption and the reprocessed emission features of Fe fluorescence and Compton scattering. The extra absorption is explained due to partial coverage by either neutral or ionized matter. We found a spectral change during the observation, which is attributable only to the change in the circumstellar absorption. Such an X-ray spectral variation is reported for the first time in dwarf novae. We speculate that the variation in the circumstellar absorption is interpreted as a time-varying disk wind or geometrically flaring disk around the white dwarf during the propagation of a heat wave inward along the accretion disk at the beginning of the outburst, in which optical outburst and X-ray quiescent states co-exist.Comment: 10 pages, 9 figures, accepted for publication in PAS

Vitrectomy combined with glial tissue removal at the optic pit in a patient with optic disc pit maculopathy: a case report

<p>Abstract</p> <p>Introduction</p> <p>We present a case of a man with optic disc pit maculopathy, whose vision improved after vitrectomy combined with glial tissue removal from the optic pit area, and without the use of photocoagulation.</p> <p>Case presentation</p> <p>A 45-year-old man complained of blurred vision, and ophthalmoscopy revealed a retinal detachment and retinoschisis extending from an optic disc pit through the macula in his left eye. He was diagnosed with optic disc pit maculopathy, and vitrectomy was performed. A posterior vitreous detachment was created, glial tissue at the optic pit was removed, and octafluoropropane (C₃F₈) was injected as a gas tamponade. The retinal detachment and retinoschisis disappeared after six months, and vision improved to 20/20 without any visual field defects (Goldmann perimetry). A cataractous lens was extracted 2 years after the vitrectomy, and vision has remained 20/20 for 10 years without any recurrence.</p> <p>Conclusion</p> <p>The removal of glial tissue during vitrectomy may be beneficial in patients with optic disc pit maculopathy.</p

Suzaku X-Ray Study of an Anomalous Source XSS J12270-4859

We report the results of the Suzaku X-ray observation of XSS J12270-4859, one of the hard X-ray sources in the INTEGRAL catalogue. The object has been classified as an intermediate polar (IP) by optical spectra and a putative X-ray period of ~860 s. With a 30 ks exposure of Suzaku, we obtained a well-exposed spectrum in the 0.2-70 keV band. We conclude against the previous IP classification based on the lack of Fe Ka emission features in the spectrum and the failure to confirm the previously reported X-ray period. Instead, the X-ray light curve is filled with exotic phenomena, including repetitive flares lasting ~100 s, occasional dips with no apparent periodicities, spectral hardening after some flares, and bimodal changes pivoting between quiet and active phases. The rapid flux changes, the dips, and the power-law spectrum point toward the interpretation that this is a low-mass X-ray binary. Some temporal characteristics are similar to those in the Rapid Burster and GRO J1744-28, making XSS J12270-4859 a very rare object.Comment: 4 pages, 3 figures, accepted for publication in PASJ Letter

AI-Driven Synthetic Route Design Incorporated with Retrosynthesis Knowledge

Computer-aided synthesis planning (CASP) aims to assist chemists in performing retrosynthetic analysis for which they utilize their experiments, intuition, and knowledge. Recent breakthroughs in machine learning (ML) techniques, including deep neural networks, have significantly improved data-driven synthetic route designs without human intervention. However, learning chemical knowledge by ML for practical synthesis planning has not yet been adequately achieved and remains a challenging problem. In this study, we developed a data-driven CASP application integrated with various portions of retrosynthesis knowledge called “ReTReK” that introduces the knowledge as adjustable parameters into the evaluation of promising search directions. The experimental results showed that ReTReK successfully searched synthetic routes based on the specified retrosynthesis knowledge, indicating that the synthetic routes searched with the knowledge were preferred to those without the knowledge. The concept of integrating retrosynthesis knowledge as adjustable parameters into a data-driven CASP application is expected to enhance the performance of both existing data-driven CASP applications and those under development

Multi-Time-Scale Input Approaches for Hourly-Scale Rainfall-Runoff Modeling based on Recurrent Neural Networks

This study proposes two straightforward yet effective approaches to reduce the required computational time of the training process for time-series modeling through a recurrent neural network (RNN) using multi-time-scale time-series data as input. One approach provides coarse and fine temporal resolutions of the input time-series to RNN in parallel. The other concatenates the coarse and fine temporal resolutions of the input time-series data over time before considering them as the input to RNN. In both approaches, first, finer temporal resolution data are utilized to learn the fine temporal scale behavior of the target data. Next, coarser temporal resolution data are expected to capture long-duration dependencies between the input and target variables. The proposed approaches were implemented for hourly rainfall-runoff modeling at a snow-dominated watershed by employing a long and short-term memory (LSTM) network, which is a newer type of RNN. Subsequently, the daily and hourly meteorological data were utilized as the input, and hourly flow discharge was considered as the target data. The results confirm that both of the proposed approaches can reduce the computational time for the training of RNN significantly (up to 32.4 times). Furthermore, one of the proposed approaches improves the estimation accuracy.Comment: 11pages, 5 figure

Atractylodes lancea rhizome derived exosome-like nanoparticles prevent alpha-melanocyte stimulating hormone-induced melanogenesis in B16-F10 melanoma cells

Aberrant melanin overproduction can significantly impact an individual's appearance and cause mental and psychological distress. Current inhibitors of melanin production exert harmful side effects due to inadequate selectivity; thus a need to develop more selective melanin synthesis inhibitors is necessary. Extracellular vesicles are important agents of intercellular signalling in prokaryotes and eukaryotes. Recently, plant-derived nanoparticles, similar to mammalian exosomes, have attracted attention for their use in health research. In this study, to investigate the potential of plant-derived exosome-like nanoparticles (ELNs) as inhibitors of melanin production, we used hot water to extract ELNs from the rhizome of Atractylodes lancea (A-ELNs). The size of A-ENLs ranged from 34 to 401 nm and carried three microRNA: ath-miR166f, ath-miR162a-5p, and ath-miR162b-5p. These A-ENLs were applied to B16-F10 melanoma cells treated with α-melanocyte-stimulating hormone (α-MSH). After A-ELNs were taken up by B16-F10 cells, their melanin levels were significantly reduced. Furthermore, A-ELNs significantly reduced tyrosinase activity in B16-F10 cells and mRNA expression of microphthalmia-associated transcription factor (Mitf), tyrosinase, tyrosinase-related protein 1, and DOPA chrome tautomerase. These results suggest that A-ELN suppresses melanogenic enzymes expression by downregulating Mitf, thereby inhibiting melanin synthesis. Hence, A-ELN can be developed into a novel topical drug after additional studies and optimization

Combined vitreous and cataract surgeries in highly hyperopic eye

We report a case of a patient with a highly hyperopic eye who underwent cataract surgery combined with vitreous surgery to create a posterior vitreous detachment (PVD) to prevent choroidal neovascularization (CNV). A 78-year-old man noticed a decrease in his vision due to a cataract in his right eye. The patient had a severe visual loss in his left eye because of a CNV 2 years after a cataract surgery. His visual acuities were 20/30 OD and 20/600 OS, and funduscopic examination showed an orange-colored lesion OD and degenerative subretinal fibrosis OS. The posterior vitreous was attached to the retina in both eyes. The axial length was 18.9 mm OD and 19.0 mm OS. Cataract surgery combined with vitreous surgery to create PVD was performed on the right eye, and the vision improved to 20/20 with no signs of developing CNV after 5 years. We conclude that cataract surgery combined with vitreous surgery to create a PVD may prevent the development of CNV in highly hyperopic eyes

Cancer Stem Cells and Aldehyde Dehydrogenase 1 in Liver Cancers

The cancer stem cell (CSC) theory posits that a small population of cells with stem cell-like features is responsible for tumor growth, resistance, and recurrence in many malignancies. This theory could be a useful paradigm for designing innovative targeted drug therapies. Liver cancer is the fifth most common cancer worldwide, with hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) as the predominant forms. Hepatic stem/progenitor cells are believed to be the origin of HCCs and CCAs; however, this remains a controversial topic. Aldehyde dehydrogenase (ALDH) is the main enzymatic system responsible for the clearance of acetaldehyde from the hepatocytes in the liver tissue. Therefore, ALDH1 has been suggested to be a potential, biological and CSC marker in liver cancers. We here provide an overview of the current state of knowledge of CSCs in liver and the role of ALDH1 in the development and progression of liver cancers and discuss its potential value as a prognostic and diagnostic biomarker

Near-Infrared and X-Ray Observations of XSS J12270-4859

XSS J12270-4859 (J12270) is an enigmatic source of unknown nature. Previous studies revealed that the source has unusual X-ray temporal characteristics, including repetitive short-term flares followed by spectral hardening, non-periodic dips, and dichotomy in activity; i.e. intervals filled with flares and those without. Together with a power-law X-ray spectrum, it is suggested to be a low-mass X-ray binary (LMXB). In order to better understand the object, we present the results of our near-infrared (NIR) photometry and linear polarimetry observations as well as X-ray spectroscopy observations, which overlap with each other partially in time, taken respectively with the InfraRed Survey Facility (IRSF) and the Rossi X-ray Timing Explorer (RXTE). We detected several simultaneous NIR and X-ray flares for the first time. No significant NIR polarization was obtained. We assembled data taken with IRSF, RXTE, Suzaku, Swift, and other missions in the literature and compared the flare profile and the spectral energy distribution (SED) with some representative high-energy sources. Based on some similarities of the repetitive NIR and X-ray flaring characteristics and the broad SED, we argue that J12270 is reminiscent of microquasars with a synchrotron jet, which is at a very low luminosity state of ~1e-4 Eddington luminosity for a stellar mass black hole or neutron star at a reference distance of 1 kpc.Comment: 12 pages, 9 figures, accepted for publication in PAS