Assessment of feasibility of projects for creating information and management systems of the electric power complex under conditions of uncertainty

Evaluating the feasibility of implementing proposed projects for creating information management systems (IMS) for industrial facilities is a complex procedure due to the uncertainty surrounding the accurate data about the prepared project during its implementation. Therefore, the application of decision support methods, based on soft computing and methodology, is deemed appropriate to address the difficulties arising from non-factors (uncertainty, non-determinism) in the evaluation of the implementation of proposed projects for IMS creation. Consequently, the use of non-deterministic interval methods has been proposed for the evaluation of the suitability of project proposals for creating information management systems under conditions of interval non-determinism, highlighting its advantages

ФОТОДИНАМИЧЕСКАЯ ТЕРАПИЯ БАЗАЛЬНОКЛЕТОЧНОГО РАКА КОЖИ ГОЛОВЫ И ШЕИ С ДОПОЛНИТЕЛЬНЫМ ВНУТРИТКАНЕВЫМ ЛАЗЕРНЫМ ОБЛУЧЕНИЕМ

The article is devoted to the development and evaluation of the effi ciency of photodynamic therapy (PDT) with photosensitizer photolon with additional interstitial laser irradiation in patients with head and  neck basal cell skin cancer (BCSC). Treatment was performed in 55  patients. On the fi rst stage, all patients underwent photodynamic  therapy with interstitial irradiation using fl exible optical fi bers with  cylindrical diffuser, on the second stage PDT with distant delivery of  laser at a dose of 50-300 J/cm2 was carried out. During the follow- up period of 6 months to 4 years in 13 (23.6%) of the 55 patients a  recurrence of the disease was diagnosed. A higher rate of recurrence was in the group of patients who underwent PDT for recurrent  neoplasms compared with patients with primary disease (37.5% and 4.3%, respectively), in patients with endophytic growth of the tumor compared to patients with exophytic component (30.0% and 16.0%,respectively) and in patients with large tumors (up to 2.0 cm – 14.3%, from 2.0 to 5.0 cm – 16.7% and more than 5.0 cm – 54.4%).Статья посвящена разработке методики и оценке эффективности фотодинамической терапии с фотосенсибилизатором фотолон с дополнительным внутритканевым воздействием  лазерного света у больных базальноклеточным раком кожи головы и шеи. Лечение проведено 55 больным. На 1-ом этапе всем больным была проведена  фотодинамическая терапия с внутритканевым облучением с использованием световодов с  гибким цилиндрическим диффузором (выходная мощность лазерного излучения – 200-400  мВт, время воздействия – 15-25 мин), на 2-ом этапе – фотодинамическая терапия с  дистанционным подведением лазерного света в дозе 50-300 Дж/см2. На сроках наблюдения  от 6 мес до 4 лет у 13 (23,6%) из 55 пациентов были диагностированы рецидивы  заболевания. Более высокий процент рецидивов был в группе больных, которым проводили  фотодинамическую терапию по поводу рецидива заболевания, чем у больных с первичными  новообразованиями (37,5% и 4,3% соответственно), у больных с эндофитным типом роста  опухоли по сравнению с больными с экзофитным компонентом образования (30,0% и  16,0%, соответственно) и у пациентов с большим размером опухолевого узла (до 2,0 см – 14,3%, от 2,1 до 5,0 см – 16,7% и более 5,0 см – 54,4%)

Электроодонтометрия пульпы зубов при вторичных зубочелюстных деформациях

The state of the nervous-receptor apparatus of teeth without opposing teeth was studied with the aid of electroodontometry. Patients were divided into three groups depending on clinical manifestations of teeth without opposing teeth. In each group, electroodontometry of the teeth was carried out. The results obtained are indicative of morphological changes in the nervous-receptor apparatus of teeth without opposing teeth and without the mastication load.Проведено исследование с целью изучения состояния нервно-рецепторного аппарата зубов, лишенных антагонистов, с помощью электроодонтометрии. В каждой группе проведена электроодонтометрия зубов, лишенных антагонистов. Полученные результаты свидетельствуют о морфологических изменениях в нервно-рецепторном аппарате зубов, лишенных антагонистов и находящихся вне функции жевания

Thermally Responsive Amphiphilic Conetworks and Gels Based on Poly(N‑isopropylacrylamide) and Polyisobutylene

Novel amphiphilic conetworks (APCN) consisting of thermoresponsive poly(N-isoproplyacrylamide) (PNiPAAm) cross-linked by hydrophobic methacrylate-telechelic polyisobutylene (MA-PIB-MA) were successfully synthesized in a broad composition range. The resulting PNiPAAm-l-PIB conetworks (“l” stands for “linked by”) were obtained by radical copolymerization of NiPAAm with MA-PIB-MA in tetrahydrofuran, a cosolvent for all the components. Low amounts of extractables substantiated efficient network formation. The composition dependent two glass transition temperatures (Tg) by DSC analysis indicate microphase separation of the cross-linked components without mixed phases. It was found that the PNiPAAm-l-PIB conetworks are uniformly swellable in both water and n-hexane; i.e., these new materials behave either as hydrogels or as hydrophobic gels in aqueous or nonpolar media, respectively. The uniform swelling in both polar and nonpolar solutes indicates cocontinuous (bicontinuous) phase morphology. The equilibrium swelling degrees (R) depend on composition, that is, the higher the PIB content, the lower the R in water and the higher in n-hexane. The PNiPAAm phase keeps its thermoresponsive behavior in the conetworks as shown by significant decrease of the swelling degree in water between 20 and 35 °C. The lower critical solubility temperature (LCST) values determined by DSC are found to decrease from 34.1 °C (for the pure PNiPAAm homopolymer) to the range of 25–28 °C in the conetworks, and the extent of the LCST decrease is proportional with the PIB content. Deswelling-swelling, i.e., heating–cooling, cycle indicates insignificant hysteresis in these new thermoresponsive materials. This indicates that PNiPAAm-l-PIB conetworks with predetermined and thermoresponsive swelling behavior can be designed and utilized in several advanced applications on the basis of results obtained in the course of this study

Angiogenesis inhibitors in the treatment of prostate cancer

Prostate cancer remains a significant public health problem, with limited therapeutic options in the setting of castrate-resistant metastatic disease. Angiogenesis inhibition is a relatively novel antineoplastic approach, which targets the reliance of tumor growth on the formation of new blood vessels. This strategy has been used successfully in other solid tumor types, with the FDA approval of anti-angiogenic agents in breast, lung, colon, brain, and kidney cancer. The application of anti-angiogenic therapy to prostate cancer is reviewed in this article, with attention to efficacy and toxicity results from several classes of anti-angiogenic agents. Ultimately, the fate of anti-angiogenic agents in prostate cancer rests on the eagerly anticipated results of several key phase III studies

Diagnostic and treatment features of ischemic heart disease in women. «The institute of therapy named after L. T. Maloy of UAMS»

The overview summarizes modern data concerning ischemic heart disease in women. Diagnostic and therapy features of disease are considered from the gender medicine points of view. Not only theoretical data are given in the paper, but also their clinical practical possible use

Diabetic encephalopathy: Pathogenesis, clinical manifestations, therapy approaches

The paper considers the epidemiology, morphology, and clinical manifestations of diabetic encephalopathy. It shows the differences of diabetic encephalopathy in types 1 and 2 diabetes mellitus. Pathogenetic treatment options for diabetic encephalopathy are given.</p

PHOTODYNAMIC THERAPY FOR HEAD AND NECK BASAL CELL SKIN CANCER WITH ADDITIONAL INTERSTITIAL LASER IRRADIATION

The article is devoted to the development and evaluation of the effi ciency of photodynamic therapy (PDT) with photosensitizer photolon with additional interstitial laser irradiation in patients with head and  neck basal cell skin cancer (BCSC). Treatment was performed in 55  patients. On the fi rst stage, all patients underwent photodynamic  therapy with interstitial irradiation using fl exible optical fi bers with  cylindrical diffuser, on the second stage PDT with distant delivery of  laser at a dose of 50-300 J/cm2 was carried out. During the follow- up period of 6 months to 4 years in 13 (23.6%) of the 55 patients a  recurrence of the disease was diagnosed. A higher rate of recurrence was in the group of patients who underwent PDT for recurrent  neoplasms compared with patients with primary disease (37.5% and 4.3%, respectively), in patients with endophytic growth of the tumor compared to patients with exophytic component (30.0% and 16.0%,respectively) and in patients with large tumors (up to 2.0 cm – 14.3%, from 2.0 to 5.0 cm – 16.7% and more than 5.0 cm – 54.4%)