2-HYDROXY-4-METHOXYBENZALDEHYDE: AROMATIC TASTE MODIFYING COMPOUND FROM MONDIA WHYTEI SKEELS

2-Hydroxy-4-methoxybenzaldehyde and 3-hydroxy-4-methoxybenzaldehyde were isolated from Mondia whytei Skeels (Asclepidiaceae). 2-Hydroxy-4-methoxybenzaldehyde was shown to have taste modifying properties. The compound was also shown to be responsible for the characteristic sweet aromatic fragrance of M. whytei root-bark. The chemical properties of 2-hydroxy-4-methoxybenzaldehyde responsible for the taste modifying character are discussed. (Received April 10, 2001; revised August 28, 2001) Bull.Chem.Soc.Ethiop. 2001, 15(2), 137-14

Repellent Properties of δ-Octalactone Against the Tsetse Fly, Glossina morsitans Morsitans

δ-octalactone, produced by several Bovidae, has been suggested as a potential repellant of tsetse fly attack. Racemic δ-octalactone was synthesized via an abbreviated route. The product was assayed against 3-day old starved teneral female tsetse flies, Glossina morsitans morsitans Wiedemann (Diptera: Glossinidae), in a choice wind tunnel and found to be a potent tsetse repellent at doses ≥0.05 mg in 200 µl of paraffin oil (0.05 >p >0.01)

Acyl-meldrum's acid in regiospecific synthesis of isotopjcally labelled compounds for polyketide biosynthetic studies

Bull. Chem. Soc. Ethiop. 1995, 9(1), 43-49

The distribution of monoterpene hydrocarbons in airborne volatiles from pseudostem of eight cultivated Banana cultivars in East Africa

Bull. Chem. Soc. Ethiop. 1996, 10(1), 43-46

The distribution of monoterpene hydrocarbons in airborne volatiles from pseudostem of eight cultivated Banana cultivars in East Africa

Bull. Chem. Soc. Ethiop. 1996, 10(1), 43-46

<b>2-Hydroxy-4-methoxybenzaldehyde: Larvicidal structure-activity studies</b>

2-Hydroxy-4-methoxybenzaldehyde (<b>1</b>), a compound isolated from <i>Mondia whytei</i> (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD₅₀ 22 &mu;g/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (<b>2</b>), 2-hydroxybenzaldehyde (<b>12</b>), 2-benzyloxybenzaldehyde (<b>3</b>) and benzylphenyl ether (<b>4</b>), showed marked improvement in activity (LD₅₀ 10, 9, 4.8, 1.2 &mu;g/mL, respectively) against <i>Anopheles gambiae</i> larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (<b>5</b>) exhibited similar activity level (LD₅₀ 28 &mu;g/mL) as <b>1</b>