Gastrointestinal stromal tumor (GIST) recurrence following surgery: review of the clinical utility of imatinib treatment

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Surgery with complete removal of the tumor is the primary treatment for resectable GIST and the only chance of cure. However, recurrence after surgery is common. The 2 main prognostic factors are the mitotic activity and the size of the tumor. Tumor rupture is also a risk factor for postoperative recurrence, and extra care should be taken while manipulating this soft and friable tumor. Imatinib mesylate (IM, Gleevec®, Novartis, Basel, Switzerland) is a tyrosine kinase inhibitor and was first studied in the palliative setting for metastatic GIST patients in the year 2000. It is now the cornerstone of metastatic GIST treatment. IM also plays an important role as an adjuvant treatment for resectable GIST and has been shown to increase the recurrence-free survival in phase III studies. However, some points remain to be clarified. Notably, the ideal duration of adjuvant IM after surgery is still unclear. It is also difficult to determine the exact place of surgery in metastatic or recurrent GIST patients in the IM era. A multidisciplinary approach is, therefore, mandatory to offer GIST patients the best treatment available

Evaluation of intersectoral collaborations : "Relevailles" and intersectoral collaborations. Brief Report.

HIGHLIGHTS • In 3 of the 4 cases, the key actor in the collaborative network was the OCF coordinator/liaison officer. • All the networks were vulnerable to the departure of a key actor. • Collaborative networks did not include any perinatal assistants. • 35 of the 37 HSSE actors involved in collaborative networks belonged to a local community services centre (CLSC), even when there was a birthing hospital or birthing centre in the HSSE. • Five determinants contributed to or constrained intersectoral collaborations between OCFs and HSSEs. • Sufficiency of resources, knowledge of the partner organization, and complementarity/flexibility in the delivery of services were determinants of collaborations. • Six modes of OCF/HSSE collaboration were identified. • There are few formal mechanisms for collaboration between organizations. • Disagreements/misunderstandings on the mechanisms for sharing information about families occurred between organizations and even within organizations. • Some parents perceived links between OCFs and CLSCs as falling into two modes of collaboration, namely 1) activating the request/recourse to partner organization services and 2) coordinating the services provided to families

Action Needs for Spatial Development in the Greater Region from a Research Perspective

Das Policy Paper ‚Handlungsbedarfe für die Raumentwicklung der Großregion aus Sicht der Forschung‘ fasst wesentliche Erkenntnisse von Forscher*innen des UniGR-Center for Border Studies in fünf für die Großregion relevanten Bereichen (Demographie und Migration, Verkehr, Beschäftigung und wirt-schaftliche Entwicklung, Energielandschaften, Grenzüberschreitende Governance) zusammen und formu-liert Handlungsoptionen für die Planungspraxis und politische Entscheidungsträger*innen.Darüber hinaus thematisiert es denWissensaustausch zwischen Forschung und Politik.Le document politique «Actions requises pour le développement territorial de la Grande Région du point de vue dela recherche» résume les principales conclusions des chercheurs de l’UniGR-Center for Border Studies dans cinq domaines pertinents pour la Grande Région (Démographie et migration, Transports, Emploi et développement économique, Paysages énergétiques, Gouvernance transfrontalière) et formule des pistes d’action pour les acteurs de la planification territoriale et les décideurs politiques. Par ailleurs, il met en exergue le transfert de savoir entre la recherche et la politique.The policy paper 'Action Needs for Spatial Development in the Greater Region from a Re-search Perspective' summarises key findings of researchers from the UniGR-Center for Border Studies in five areas relevant to the Greater Region (demography and migration, transport, employment and economic development, energy landscapes, cross-border governance) and formulates options for action for planning practice and political decision-makers. In addition, it addresses the exchange of knowledge between re-search and politics.Center for Border Studies de l'Université de la Grande Région - UniGR-CB

Ressources minières dans les Amériques : Mutations d’un continent

Numéro coordonné par Sandrine Tolazzi, Susanne Berthier-Foglar et Franck Gaudichaud en collaboration avec le comité de rédaction. Secrétariat de rédaction : Claire Bouffard, avec la participation de Laura Henr