71 research outputs found
Equation of state and magnetic susceptibility of spin polarized isospin asymmetric nuclear matter
Properties of spin polarized isospin asymmetric nuclear matter are studied
within the framework of the Brueckner--Hartree--Fock formalism. The
single-particle potentials of neutrons and protons with spin up and down are
determined for several values of the neutron and proton spin polarizations and
the asymmetry parameter. It is found an almost linear and symmetric variation
of the single-particle potentials as increasing these parameters. An analytic
parametrization of the total energy per particle as a function of the asymmetry
and spin polarizations is constructed. This parametrization is employed to
compute the magnetic susceptibility of nuclear matter for several values of the
asymmetry from neutron to symmetric matter. The results show no indication of a
ferromagnetic transition at any density for any asymmetry of nuclear matter.Comment: 23 pages, 8 figures, 2 tables (submitted to Phys. Rev. C
Ferromagnetic instabilities in neutron matter at finite temperature with the Skyrme interaction
Early objective response to avelumab treatment is associated with improved overall survival in patients with metastatic Merkel cell carcinoma
Background: Response rates are primary endpoints in many oncology trials; however, correlation with overall survival (OS) is not uniform across cancer types, treatments, or lines of therapy. This study explored the association between objective response (OR) and OS in patients with chemotherapy-refractory metastatic Merkel cell carcinoma who received avelumab (anti-PD-L1). Methods: Eighty-eight patients enrolled in JAVELIN Merkel 200 (part A; NCT02155647) received i.v. avelumab 10 mg/kg every 2 weeks until confirmed progression, unacceptable toxicity, or withdrawal. Using conditional landmark analyses, we compared OS in patients with and without confirmed OR (RECIST v1.1). We applied a Cox model that included OR as a time-varying covariate and adjusted for age, visceral disease, and number of previous therapies. Results: Twenty-nine patients had confirmed OR; 20 by study week 7 and 7 more between study weeks 7 and 13. Survival probabilities 18 months after treatment initiation were 90% [95% confidence interval (CI) 65.6-97.4] in patients with OR at week 7 and 26.2% (95% CI 15.7-37.8) in patients without OR but who were alive at week 7. Median OS was not reached in patients with OR and was 8.8 months (95% CI 6.4-12.9) in patients without. Similar results were observed for the week 13 landmark. The adjusted Cox model showed OR was associated with a 95% risk reduction of death [hazard ratio 0.052 (95% CI 0.018-0.152)] compared with a nonresponse. Conclusions: Patients with OR by 7 or 13 weeks had significantly longer OS than patients without, confirming that early OR is an endpoint of major importance
Can opportunities be enhanced for vaccinating children in home visiting programs? A population-based cohort study
Familial linear scleroderma (en coup de sabre) responsive to antimalarials and narrowband ultraviolet B therapy
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