DACUM: A National Database Justifying the Study of Speech Communication

This article proposes that Developing A Curriculum (DACUM), a standardized curriculum development process, be tapped to justify the study of speech communication in higher education. DACUM is a standardized method for determining curricular needs. Its purpose is to identify the duties, tasks and skills performed in a particular occupation, career area or profession. DACUM assumes that successful workers are best equipped to identify the competencies needed in their specific occupation. DACUM was created by he Canada Department of Manpower and Immigration and the General Learning Corp. of New York

Divergent Whole Brain Projections from the Ventral Midbrain in Macaques

To understand the connectome of the axonal arborizations of dopaminergic midbrain neurons, we investigated the anterograde spread of highly sensitive viral tracers injected into the ventral tegmental area (VTA) and adjacent areas in 3 macaques. In 2 monkeys, injections were centered on the lateral VTA with some spread into the substantia nigra, while in one animal the injection targeted the medial VTA with partial spread into the ventro-medial thalamus. Double-labeling with antibodies against transduced fluorescent proteins (FPs) and tyrosine hydroxylase indicated that substantial portions of transduced midbrain neurons were dopaminergic. Interestingly, cortical terminals were found either homogeneously in molecular layer I, or more heterogeneously, sometimes forming patches, in the deeper laminae II-VI. In the animals with injections in lateral VTA, terminals were most dense in somatomotor cortex and the striatum. In contrast, when the medial VTA was transduced, dense terminals were found in dorsal prefrontal and temporal cortices, while projections to striatum were sparse. In all monkeys, orbitofrontal and occipito-parietal cortex received strong and weak innervation, respectively. Thus, the dopaminergic ventral midbrain sends heterogeneous projections throughout the brain. Furthermore, our results suggest the existence of subgroups in meso-dopaminergic neurons depending on their location in the primate ventral midbrain

A deep-narrative analysis of energy cultures in slum rehabilitation housing of Abuja, Mumbai and Rio de Janeiro for just policy design

Slum rehabilitation housing (SRH) are critical transitional spaces in urban informality that has deep-rooted implications on poverty alleviation efforts. However, current literature reports systemic injustices in SRH on access to essential services, including energy injustices. This study investigated distributive injustices in the SRH across three cities, Abuja, Mumbai and Rio de Janeiro, developing ‘energy cultures’ narratives. It employed a computational social science methodology that used textual analysis, followed by a constructivist grounded theoretic approach to inform just policy design. The analysis was performed at two scales to identify and contrast injustices in the study areas. The result at an aggregated scale showed commonalities were around the poor design of the built environment, administrative lags of the utilities and high electricity bills. Case study-specific results showed that poverty penalties were linked with the energy cultures of each SRHs. In the Mumbai case, poverty penalties were associated with the aspirational purchase of household appliances due to move from slums to SRH. The Abuja case showed low power quality and load shedding frequently damaged appliances that increase the maintenance costs for the occupants. The Rio de Janeiro SRH case had injustices embedded through the adoption of inefficient appliances received as charity from higher-income households. Fuel stacking was also observed in the SRH that illustrated cultural identities associated with cooking energy. The conclusion was drawn to support just policy design by considering the socio-cultural context of the built environment, improving utility governance and promoting cleaner fuel mix at the household level

Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys

Responses of midbrain dopamine (DA) neurons reflecting expected reward from sensory cues are critical for reward-based associative learning. However, critical pathways by which reward-related visual information is relayed to DA neurons remain unclear. To address this question, we investigated Pavlovian conditioning in macaque monkeys with unilateral primary visual cortex (V1) lesions (an animal model of 'blindsight'). Anticipatory licking responses to obtain juice drops were elicited in response to visual conditioned stimuli (CS) in the affected visual field. Subsequent pharmacological inactivation of the superior colliculus (SC) suppressed the anticipatory licking. Concurrent single unit recordings indicated that DA responses reflecting the reward expectation could be recorded in the absence of V1, and that these responses were also suppressed by SC inactivation. These results indicate that the subcortical visual circuit can relay reward-predicting visual information to DA neurons and integrity of the SC is necessary for visually-elicited classically conditioned responses after V1 lesion

The Contraceptive Effect of the Extract Methanol of The Leaves Hydrocotyle Javanica Thumb on Female Mice

The aim of this study is to investigate the contraceptive effect of the extract methanol of the leavesHydrocotyle javanica Thumb and its effect threat of implantation, the quantity and condition of fetuses,histology appearance of the ovary and uterus and rate of pregnancy. The female mice were given orallyeither methanol extract of leaves, for 10 days in various doses: 20, 40, 60, and 80 gram/kg BW. On day20, the mice were mated and when pregnancy occurred, treatment was stopped. On day 17 of pregnancy,the mice were sacrificed: uterus and ovaries were examined histologically. In conclusion, methanol extractof Hydrocotyle javanica Thumb shows contraceptive activity (P 0.05).Keywords: extract methanol, Hydrocotyle javanica Thumb, contraceptiv

The non-genomic effects of high doses of Rosiglitazone on cell growth and apoptosis in cultured monocytic cells

Peroxisome Proliferator-Activated Receptor gamma (PPARγ) is a ligand-activated transcription factor which belongs to the nuclear hormone superfamily and has multiple pharmacological ligands called Thiazolidinediones (TZDs). TZDs are a class of drugs used in the treatment of type 2 diabetic patients. Rosiglitazone is one such TZD, and is used clinically to treat type 2 diabetes. In this study, the effect of Rosiglitazone on cell growth and apoptosis in cultured monocytic monomac 6 (MM6) cells was investigated. Over a 14 day period, MM6 cells were cultured in vitro and treated with 1μM and 10μM Rosiglitazone. Cell viability and proliferation were evaluated by Haemocytometer cell count and MTS assay respectively. Turbidity due to cell density was assessed spectrophotometrically. Apoptosis was determined by Caspase-Glo 3/7 assay. Expression of the endoplasmic reticulum (ER) stress-inducible protein sarco-endoplasmic reticulum Ca2+ATPase-2b (SERCA2b) was determined by Western blot. Neither 1μM nor 10μM Rosiglitazone exerted statistically significant inhibitory effects on cell proliferation, turbidity due to cell density, or cell viability (p > 0.05 in all cases). In contrast, Rosiglitazone induced increased apoptosis, but a significant difference was only observed in 10μM-treated cells compared with control cells (3.04 ± 0.52 control; p < 0.05) while 1μM-treated cells showed a non-significant increase (1.50 ± .06 control; p > 0.05). Meanwhile the expression of SERCA2b was up-regulated significantly in cells treated for >4hrs (e.g 2.45 ± 0.06 control at 24 hrs; p < 0.05) with 10μM Rosiglitazone. It was concluded that high doses (10μM) of Rosiglitazone up-regulate SERCA2b expression and induce apoptosis of MM6 cells by activating an ER stress response via a PPARγ-independent mechanism. The therapeutic relevance of these observations is a matter for further investigations. Key words: Rosiglitazone, PPARγ, Monocytes, ER Stress, SERCA2b, Apoptosi