3,566 research outputs found
Fracture surface characteristics of notched angleplied graphite/epoxy composites
Composite fracture surface characteristics and related fracture modes have been investigated through extensive microscopic inspections of the fracture surfaces of notched angleplied graphite/epoxy laminates. The investigation involved 4 ply laminates of the configuration + or - theta (s) where theta = 0 deg, 3 deg, 5 deg, 10 deg, 15 deg, 30 deg, 45 deg, 60 deg, 75 deg, and 90 deg. Two-inch wide tensile specimens with 0.25 in. by 0.05 in. through-slits centered across the width were tested to fracture. The fractured surfaces were then removed and examined using a scanning electron microscope. Evaluation of the photomicrographs combined with analytical results obtained using the CODSTRAN computer code culminated in a unified set of fracture criteria for determining the mode of fracture in notched angleplied graphite/epoxy laminates
Strong coupling between single photons in semiconductor microcavities
We discuss the observability of strong coupling between single photons in
semiconductor microcavities coupled by a chi(2) nonlinearity. We present two
schemes and analyze the feasibility of their practical implementation in three
systems: photonic crystal defects, micropillars and microdisks, fabricated out
of GaAs. We show that if a weak coherent state is used to enhance the chi(2)
interaction, the strong coupling regime between two modes at different
frequencies occupied by a single photon is within reach of current technology.
The unstimulated strong coupling of a single photon and a photon pair is very
challenging and will require an improvement in mirocavity quality factors of
2-4 orders of magnitude to be observable.Comment: 4 page
Spin gating electrical current
We use an aluminium single electron transistor with a magnetic gate to
directly quantify the chemical potential anisotropy of GaMnAs materials.
Uniaxial and cubic contributions to the chemical potential anisotropy are
determined from field rotation experiments. In performing magnetic field sweeps
we observe additional isotropic magnetic field dependence of the chemical
potential which shows a non-monotonic behavior. The observed effects are
explained by calculations based on the kinetic
exchange model of ferromagnetism in GaMnAs. Our device inverts the conventional
approach for constructing spin transistors: instead of spin-transport
controlled by ordinary gates we spin-gate ordinary charge transport.Comment: 5 pages, 4 figure
Lithographically and electrically controlled strain effects on anisotropic magnetoresistance in (Ga,Mn)As
It has been demonstrated that magnetocrystalline anisotropies in (Ga,Mn)As
are sensitive to lattice strains as small as 10^-4 and that strain can be
controlled by lattice parameter engineering during growth, through post growth
lithography, and electrically by bonding the (Ga,Mn)As sample to a
piezoelectric transducer. In this work we show that analogous effects are
observed in crystalline components of the anisotropic magnetoresistance (AMR).
Lithographically or electrically induced strain variations can produce
crystalline AMR components which are larger than the crystalline AMR and a
significant fraction of the total AMR of the unprocessed (Ga,Mn)As material. In
these experiments we also observe new higher order terms in the
phenomenological AMR expressions and find that strain variation effects can
play important role in the micromagnetic and magnetotransport characteristics
of (Ga,Mn)As lateral nanoconstrictions.Comment: 11 pages, 4 figures, references fixe
Motherhood in the teens and twenties: some surprises.
We report a study of the association of health and social support variables with motherhood in teenagers and older mothers. Both teenage and older mothers reported poorer physical and mental health and fewer and less frequent social contacts than their nulliparous peers. Contrary to expectation, however, older mothers reported less extensive and less adequate social support networks than did teenagers
Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles
Regulating molecular interactions in the T-cell synapse to prevent autoimmunity or, conversely, to boost anti-tumor immunity has long been a goal in immunotherapy. However, delivering therapeutically meaningful doses of immune-modulating compounds into the synapse represents a major challenge. Here, we report that covalent coupling of maleimide-functionlized nanoparticles (NPs) to free thiol groups on T-cell membrane proteins enables efficient delivery of compounds into the T-cell synapse. We demonstrate that surface-linked NPs are rapidly polarized toward the nascent immunological synapse (IS) at the T-cell/APC contact zone during antigen recognition. To translate these findings into a therapeutic application we tested the NP delivery of NSC-87877, a dual inhibitor of Shp1 and Shp2, key phosphatases that downregulate T-cell receptor activation in the synapse, in the context of adoptive T cell therapy of cancer. Conjugating NSC-87877-loaded NPs to the surface of tumor-specific T cells just prior to adoptive transfer into mice with advanced prostate cancer promoted a much greater T-cell expansion at the tumor site, relative to co-infusing the same drug dose systemically, leading to enhanced survival of treated animals. In summary, our studies support the application of T-cell-linked synthetic NPs as efficient drug delivery vehicles into the IS, as well as the broad applicability of this new paradigm for therapeutically modulating signaling events at the T-cell/APC interface.National Institutes of Health (U.S.) (CA140476)National Institutes of Health (U.S.) (EB123622)United States. Dept. of Defense. Prostate Cancer Research Program (W81XWH-10-1-0290)National Cancer Institute (U.S.) (Cancer Center Support (Core) Grant P30-CA14051)National Cancer Institute (U.S.)American Cancer Society (Postdoctoral Fellowship 12109-PF-11-025-01-LIB
Projected free energies for polydisperse phase equilibria
A `polydisperse' system has an infinite number of conserved densities. We
give a rational procedure for projecting its infinite-dimensional free energy
surface onto a subspace comprising a finite number of linear combinations of
densities (`moments'), in which the phase behavior is then found as usual. If
the excess free energy of the system depends only on the moments used, exact
cloud, shadow and spinodal curves result; two- and multi-phase regions are
approximate, but refinable indefinitely by adding extra moments. The approach
is computationally robust and gives new geometrical insights into the
thermodynamics of polydispersity.Comment: 4 pages, REVTeX, uses multicol.sty and epsf.sty, 1 postscript figure
include
Reconfigurable Boolean Logic using Magnetic Single-Electron Transistors
We propose a novel hybrid single-electron device for reprogrammable low-power
logic operations, the magnetic single-electron transistor (MSET). The device
consists of an aluminium single-electron transistors with a GaMnAs magnetic
back-gate. Changing between different logic gate functions is realized by
reorienting the magnetic moments of the magnetic layer which induce a voltage
shift on the Coulomb blockade oscillations of the MSET. We show that we can
arbitrarily reprogram the function of the device from an n-type SET for
in-plane magnetization of the GaMnAs layer to p-type SET for out-of-plane
magnetization orientation. Moreover, we demonstrate a set of reprogrammable
Boolean gates and its logical complement at the single device level. Finally,
we propose two sets of reconfigurable binary gates using combinations of two
MSETs in a pull-down network
Manipulating O3/P2 phase ratio in bi-phasic sodium layered oxides via ionic radius control
Funding: This work was supported by the Faraday Institution (Grant number FIRG018). The authors would like to thank Dr. David Rochester at Lancaster University for conducting the ICP-OES experiments. A.B.N. would like to acknowledge funding by the Engineering and Physical Sciences Research Council under grant numbers EP/L017008/1, EP/R023751/1, and EP/T019298/1 for the electron microscopy analysis.Bi-phasic O3/P2 sodium layered oxides have emerged as leading candidates for the commercialisation of next-generation sodium-ion batteries. However, beyond simply altering the sodium content, rational control of the O3/P2 ratio in these materials has proven particularly challenging despite being crucial for the realization of high-performance electrode materials. Here, using abundant elements, we manipulate the O3/P2 ratio using the average ionic radius of the transition metal layer and different synthesis conditions. These methods allow deterministic control over the O3/P2 ratio, even for constant Na contents. In addition, tuning the O3/P2 ratio yields high-performing materials with different performance characteristics, with a P2-rich material achieving high rate capabilities and excellent cycling stability (92% retention, 50 cycles), while an O3-rich material displayed an energy density up to 430 Wh kg−1, (85%, 50 cycles). These insights will help guide the rational design of future high-performance materials for sodium-ion batteries.Publisher PDFPeer reviewe
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