Ursinus College Alumni Journal, Winter 1943

Current comment: In memoriam; Remember the loyalty fund • President\u27s page • The Navy program • 74th Academic year begun • Coach Stevens to enter Army • Messages to the alumni • Athletic program • Letters from the fronts • News about ourselves • Ursinus men and women in the armed forceshttps://digitalcommons.ursinus.edu/alumnijournal/1019/thumbnail.jp

Ursinus College Alumni Journal, Spring 1944

Editor\u27s page: Regrets and best wishes; Thank you for writing; Don\u27t forget to vote • President\u27s page • Our war correspondents • Resignation of Jing Johnson • Commencement • Opening of new term • Forums • Men\u27s sports • Messiah • Dr. Haines visits campus • Alumni news • Letters to the alumni • Women\u27s sports • Prominent alumni pass away: Dr. Stibitz; Congressman Ditter dies • Supply store • Men and women in the service • Navy needs officers • Library receives gifts • Alumni association nomineeshttps://digitalcommons.ursinus.edu/alumnijournal/1020/thumbnail.jp

Ursinus College Alumni Journal, Summer 1944

In memoriam • Education for peace • President\u27s page • Our war correspondents • Alumni secretary resigns • Mrs. Leighton K. Smith elected to fill vacancy • 74th annual commencement • Alumni Association reelects Jing Johnson • Local alumni groups meet • News about ourselves • New term opens • Forum speakers • Pre-med society meetings • Dr. Hart speaks at vespers • Annual May Day • Carter elected president local A.A.U.P. chapter • Post-war plans discussed • Men and women in the service • Report on the Loyalty Fundhttps://digitalcommons.ursinus.edu/alumnijournal/1021/thumbnail.jp

Ursinus College Alumni Journal, Winter 1944

In memoriam • President\u27s page • Our war correspondents • Directors meet • Library notes • Faculty and staff changes • Summer term ends • Third highest enrollment recorded • Sports revue • News about ourselves • Necrology • Men and women in the service • Sacred halls invaded by army of femmes • Letters to the alumnihttps://digitalcommons.ursinus.edu/alumnijournal/1022/thumbnail.jp

Educational Barriers of Rural Youth: Relation of Individual and Contextual Difference Variables

The purpose of this study was to examine the relation of several individual and contextual difference factors to the perceived educational barriers of rural youth. Data were from a broader national investigation of students’ postsecondary aspirations and preparation in rural high schools across the United States. The sample involved more than 7,000 rural youth in 73 high schools across 34 states. Results indicated that some individual (e.g., African American race/ethnicity) and contextual (e.g., parent education) difference factors were predictive while others were not. Extensions to, similarities, and variations with previous research are discussed. Implications, limitations, and suggestions for future research are also discussed

The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of “Tail Wags Dog” Experiments

This work is licensed under a Creative Commons Attribution 4.0 International License.(−)-N-Phenethyl analogs of optically pure N-norhydromorphone were synthesized and pharmacologically evaluated in several in vitro assays (opioid receptor binding, stimulation of [35S]GTPγS binding, forskolin-induced cAMP accumulation assay, and MOR-mediated β-arrestin recruitment assays). “Body” and “tail” interactions with opioid receptors (a subset of Portoghese’s message-address theory) were used for molecular modeling and simulations, where the “address” can be considered the “body” of the hydromorphone molecule and the “message” delivered by the substituent (tail) on the aromatic ring of the N-phenethyl moiety. One compound, N-p-chloro-phenethynorhydromorphone ((7aR,12bS)-3-(4-chlorophenethyl)-9-hydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one, 2i), was found to have nanomolar binding affinity at MOR and DOR. It was a potent partial agonist at MOR and a full potent agonist at DOR with a δ/μ potency ratio of 1.2 in the ([35S]GTPγS) assay. Bifunctional opioids that interact with MOR and DOR, the latter as agonists or antagonists, have been reported to have fewer side-effects than MOR agonists. The p-chlorophenethyl compound 2i was evaluated for its effect on respiration in both mice and squirrel monkeys. Compound 2i did not depress respiration (using normal air) in mice or squirrel monkeys. However, under conditions of hypercapnia (using air mixed with 5% CO2), respiration was depressed in squirrel monkeys.NIDA grant P30 DA13429NIDA grant DA039997NIDA grant DA018151NIDA grant DA035857NIDA grant DA047574NIH Intramural Research Programs of the National Institute on Drug AbuseNational Institute of Alcohol Abuse and AlcoholismNIH Intramural Research Programs of the National Institute on Drug AbuseNIH Intramural Research Program through the Center for Information TechnologyNIH Intramural Research Programs of the National Institute on Drug Abus

Manual / Issue 11 / Repair

Manual, a journal about art and its making. Repair. Can we find in the detail, in the stitch and the weave, an ecology of care, a model for activating new forms of life, ones that might reject or reimagine an economic and cultural order based on novelty, disposability, and the monadic self? Can they help us learn to live together in a broken world? —Brian Goldberg and Kate Irvin, from the preface to Issue 11 This volume complemented the exhibition Repair and Design Futures, on view at the RISD Museum October 5, 2018 through June 30, 2019. Softcover, 96 pages. Published 2018 by the RISD Museum. Manual 11 (Repair) contributors include Markus Berger, Gina Borromeo, Linda Catano, Thomas Denenberg, Daniel Eatock, Brian Goldberg, Ramiro Gomez, Kate Irvin, Anna Rose Keefe, Olivia Laing, Steven Lubar, Roberto Lugo, Lisa Z. Morgan, Maureen C. O’Brien, Barry Schwabsky, Sharma Shields, Jessica Urick, and Liliane Wong.https://digitalcommons.risd.edu/risdmuseum_journals/1037/thumbnail.jp

Drug-gene interactions of antihypertensive medications and risk of incident cardiovascular disease: a pharmacogenomics study from the CHARGE consortium

Background Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke. In the US, over 65 million people have high blood pressure and a large proportion of these individuals are prescribed antihypertensive medications. Although large long-term clinical trials conducted in the last several decades have identified a number of effective antihypertensive treatments that reduce the risk of future clinical complications, responses to therapy and protection from cardiovascular events vary among individuals. Methods Using a genome-wide association study among 21,267 participants with pharmaceutically treated hypertension, we explored the hypothesis that genetic variants might influence or modify the effectiveness of common antihypertensive therapies on the risk of major cardiovascular outcomes. The classes of drug treatments included angiotensin-converting enzyme inhibitors, beta-blockers, calcium channel blockers, and diuretics. In the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, each study performed array-based genome-wide genotyping, imputed to HapMap Phase II reference panels, and used additive genetic models in proportional hazards or logistic regression models to evaluate drug-gene interactions for each of four therapeutic drug classes. We used meta-analysis to combine study-specific interaction estimates for approximately 2 million single nucleotide polymorphisms (SNPs) in a discovery analysis among 15,375 European Ancestry participants (3,527 CVD cases) with targeted follow-up in a case-only study of 1,751 European Ancestry GenHAT participants as well as among 4,141 African-Americans (1,267 CVD cases). Results Although drug-SNP interactions were biologically plausible, exposures and outcomes were well measured, and power was sufficient to detect modest interactions, we did not identify any statistically significant interactions from the four antihypertensive therapy meta-analyses (Pinteraction > 5.0×10−8). Similarly, findings were null for meta-analyses restricted to 66 SNPs with significant main effects on coronary artery disease or blood pressure from large published genome-wide association studies (Pinteraction ≥ 0.01). Our results suggest that there are no major pharmacogenetic influences of common SNPs on the relationship between blood pressure medications and the risk of incident CVD