Desenvolvimento de atividade criativa de alunos-designers método de cartões associativos metafóricos (Mac)

The article presents the results of a study of the development of creative activity of students- designers in the artistic and project activities using the method of metaphorical associative cards. Creative activity is considered as a personal feature (set of properties and qualities of a person), its orientation and readiness for the implementation of artistic and project activities. The development of creative activity is conditioned by the necessity of forming the individual's need for creative activity, which will become the student's personal quality. To diagnose the development of creative activity, we offered a method of metaphorical associative cards. The works of artists, natural phenomena, and textures are offered as the metaphorical cards. Based on the selected cards, the students make the training tasks. As a result of a comparative analysis of the diagnosis of the zero and control stages of the creative works of the experimental group, we obtained quantitative and qualitative data that comprehensively characterize the level of development of creative activity of students in accordance with the criteria we have singled out. The reliability of the evaluation of obtained results was determined with the help of mathematical and static processing of the obtained data. To determine the effectiveness of this method, we used the questionnaires made by such authors as M. I. Rozhkova and L.V. Mishchenko, comparative analysis and observation methods. The criteria were determined as the need for mastering and acquiring new knowledge; the conceptual design - the use of expressive means in the composition solution.El artículo presenta los resultados de un estudio sobre el desarrollo de la actividad activa de los diseñadores de la industria en las actividades de diseño y de diseño con el método de las asociaciones de gráficos. La actividad cultural se considera como una característica personal y una orientación para la implementación de las actividades y las actividades de diseño. El desarrollo de la actividad económica está condicionado por la necesidad de formar a los individuos necesarios para la actividad activa, que convertirá a la calidad de la calidad personal. Para diagnosticar el desarrollo de la actividad activa, hemos planteado un método de metáforas asociadas. Las obras de los artistas, natural phenomena, y las texturas se presentan las cartas metaphorical. Basado en las cartas seleccionadas, los estudiantes realizan las tareas de formación. Las que resultan de un análisis comparativo de los diagnósticos de las etapas del ensayo y de las e tapas del desarrollo de las generaciones de trabajo del grupo experimental, obtenidos cuantitativa y cualitativa, que coinciden con el nivel del desarrollo del crecimiento de la actividad activa de los estudiantes de acuerdo con el criterio sencillo. La confiabilidad de la evaluación de resultados obtenidos se determinó con la ayuda de método matemático y de procesamiento de datos obtenidos. Para determinar la eficacia de este método, utilizamos los cuestionarios hechos por los autores de las M. I. Rozhkova y L.V. Mishchenko, comparativa de análisis y métodos de observación. Los criterios fueron determinados a los requeridos para el mastering y acquiring new knowledge; el diseño conceptual - el uso de la expresión expresiva en la solución de solución.O artigo apresenta os resultados de um estudo sobre o desenvolvimento da atividade criativa de estudantes-designers nas atividades artísticas e de projeto, utilizando o método de cartões associativos metafóricos. A atividade criativa é considerada como uma característica pessoal (conjunto de propriedades e qualidades de uma pessoa), sua orientação e prontidão para a implementação de atividades artísticas e de projeto. O desenvolvimento da atividade criativa é condicionado pela necessidade de formar a necessidade individual de atividade criativa, que se tornará a qualidade pessoal do aluno. Para diagnosticar o desenvolvimento da atividade criativa, oferecemos um método de cartões associativos metafóricos. As obras de artistas, fenômenos naturais e texturas são oferecidas como cartões metafóricos. Com base nos cartões selecionados, os alunos realizam as tarefas de treinamento. Como resultado de uma análise comparativa do diagnóstico do zero e estágios de controle dos trabalhos criativos do grupo experimental, foram obtidos dados quantitativos e qualitativos que exaustivamente caracterizar o nível de desenvolvimento da actividade criativa dos alunos de acordo com os critérios Nós temos destacado. A confiabilidade da avaliação dos resultados obtidos foi determinada com o auxílio do processamento matemático e estático dos dados obtidos. Para determinar a eficácia deste método, usamos os questionários feitos por autores como M. I. Rozhkova e L.V. Mishchenko, análise comparativa e métodos de observação. Os critérios foram determinados como a necessidade de dominar e adquirir novos conhecimentos; O design conceitual - o uso de meios expressivos na solução de composição

Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians.

In spite of progress in cardiovascular genetics, data on genetic background of myocardial infarction are still limited and contradictory. This applies as well to the genes involved in inflammation and coagulation processes, which play a crucial role in the disease etiopathogenesis.In this study we found genetic variants of TGFB1, FGB and CRP genes associated with myocardial infarction in discovery and replication groups of Russian descent from the Moscow region and the Republic of Bashkortostan (325/185 and 220/197 samples, correspondingly). We also found and replicated biallelic combinations of TGFB1 with FGB, TGFB1 with CRP and IFNG with PTGS1 genetic variants associated with myocardial infarction providing a detectable cumulative effect. We proposed an original two-component procedure for the analysis of nonlinear (epistatic) interactions between the genes in biallelic combinations and confirmed the epistasis hypothesis for the set of alleles of IFNG with PTGS. The procedure is applicable to any pair of logical variables, e.g. carriage of two sets of alleles. The composite model that included three single gene variants and the epistatic pair has AUC of 0.66 both in discovery and replication groups.The genetic impact of TGFB1, FGB, CRP, IFNG, and PTGS and/or their biallelic combinations on myocardial infarction was found and replicated in Russians. Evidence of epistatic interactions between IFNG with PTGS genes was obtained both in discovery and replication groups

The map of possible interactions between components of MI-associated biallelic combination <i>IFNG</i> and <i>PTGS1</i> (black circles) and ten relative partners (gray circles) generated by GeneMania online software [45].

<p>Possible physical interactions (pink), co-expression (violet), pathway (blue), genetic interactions (green), and shared protein domains (yellow) are shown. IDO1 –indoleamine 2,3–dioxygenase 1; IFNG–interferon gamma; IFNGR1 –interferon gamma receptor 1; IFNGR2 –interferon gamma receptor 2; IRF1 –interferon regulatory factor 1; MPO–myeloperoxidase; PTGIS–prostaglandin I2 (prostacyclin) synthase; PRKCD–protein kinase C delta; PTGS1 –prostaglandin–endoperoxide synthase 1; PTGS2 –prostaglandin–endoperoxide synthase 2; PTPN2 –protein tyrosine phosphatase, non–receptor type 2; PTPN6 –protein tyrosine phosphatase, non–receptor type 6.</p

ROC curves demonstrate usefulness of the additive composite model built from all identified genetic markers.

<p><b>A</b>. Comparing performance of the composite model to the performance of each single marker in the Moscow discovery sample. Combining the high specificity of <i>CRP</i> and <i>IFNG</i>+<i>PTGS</i> predictors (the left hump) with relatively high sensitivity of <i>TGFB1</i> and <i>FGB</i> (the right hump) yields a much better classifier. <b>B</b>. Performance of the model stays the same when tested on the independent replication sample (Bashkortostan).</p