The dust-to-gas mass ratio of luminous galaxies as a function of their metallicity at cosmic noon

We aim to quantify the relation between the dust-to-gas (DTG) mass ratio and gas-phase metallicity of $z=$2.1-2.5 luminous galaxies and contrast this high-redshift relation against analogous constraints at $z=$0. We present a sample of 10 star-forming main-sequence galaxies in the redshift range $2.1<z<2.5$ with rest-optical emission-line information available from the MOSDEF survey and with ALMA 1.2 millimeter and CO J$=$3--2 follow-up observations. The galaxies have stellar masses ranging from $10^{10.3}$ to $10^{10.6}\,\rm{M}_\odot$ and cover a range in star-formation rate from 35 to 145 $\rm{M}_\odot\,\rm{yr}^{-1}$. We calculate the gas-phase oxygen abundance of these galaxies from rest-optical nebular emission lines (8.4 < $12 + \log{(\rm{O/H})} < 8.8$, corresponding to 0.5-1.25 Z$_\odot$). We estimate the dust and H2 masses (using a metallicity dependent CO-to-H2 conversion factor) of the galaxies from the 1.2 mm and CO J$=$3-2 observations, respectively, from which we estimate a DTG. We find that the galaxies in this sample follow the earlier observed trends between CO line luminosity and dust-continuum luminosity from $z=0$ to $z=3$, extending such trends to fainter galaxies at $2.1<z<2.5$ than observed to date. We find no second-order metallicity dependence in the CO - dust-continuum luminosity relation for the galaxies presented in this work. The DTG of main-sequence galaxies at $2.1<z<2.5$ are consistent with an increase in DTG with gas-phase metallicity. Galaxies at $z=$2.1-2.5 are furthermore consistent with the DTG-metallicity relation found at $z=$0, providing relevant constraints for galaxy formation models. These results furthermore imply that the metallicity of galaxies should be taken into account when estimating cold-gas masses from dust-continuum emission, especially relevant when studying metal-poor low-mass or high-redshift galaxies. [abridged]Comment: Submitted to A&A, 7 pages. Figure 4 is the key figur

Lessons for Flying Astronauts with Disabilities Drawn from Experience in Aviation

INTRODUCTION: A ccessible spaceflight may seem a distant concept. As part of a diverse European Space Agency funded Topical Team, we are working on the physiological feasibility of space missions being undertaken by people with physical disabilities. Here, the first activity of this team is presented in the form of key lessons learned from aviation to inform new work on space missions. DISCUSSION: The first lesson is agreeing on realistic expectations about impairments, their severity, and the possibility of flying independently. This is important in terms of astronaut recruitment and societal expectations. The second lesson relates to training and adjustments for people with disabilities. Flexibility is important while maintaining safety for everyone involved. The third lesson is about managing unconscious bias from the different stakeholders. We conclude by arguing that engagement with people from different backgrounds is essential for the success of the first space mission with people with physical disabilities.</p

The MOSDEF Survey: [SIII] as a New Probe of Evolving ISM Conditions

We present measurements of [SIII]$\lambda\lambda$9069,9531 for a sample of $z\sim1.5$ star-forming galaxies, the first sample with measurements of these lines at z&gt;0.1. We employ the line ratio S$_{32}$$\equiv$[SIII]$\lambda\lambda$9069,9531/[SII]$\lambda\lambda$6716,6731 as a novel probe of evolving ISM conditions. Since this ratio includes the low-ionization line [SII], it is crucial that the effects of diffuse ionized gas (DIG) on emission-line ratios be accounted for in $z\sim0$ integrated galaxy spectra, or else that comparisons be made to samples of local HII regions in which DIG emission is not present. We find that S$_{32}$ decreases with increasing stellar mass at both $z\sim1.5$ and $z\sim0$, but that the dependence is weak suggesting S$_{32}$ has a very shallow anticorrelation with metallicity, in contrast with O$_{32}$ that displays a strong metallicity dependence. As a result, S$_{32}$ only mildly evolves with redshift at fixed stellar mass. The $z\sim1.5$ sample is systematicallty offset towards lower S$_{32}$ and higher [SII]/H$\alpha$ at fixed [OIII]/H$\beta$ relative to $z=0$ HII regions. By comparing to photoionization model grids, we find that such trends can be explained by a scenario in which the ionizing spectrum is harder at fixed O/H with increasing redshift, but are inconsistent with an increase in ionization parameter at fixed O/H. This analysis demonstrates the advantages of expanding beyond the strongest rest-optical lines for evolutionary studies, and the particular utility of [SIII] for characterizing evolving ISM conditions and stellar compositions. These measurements provide a basis for estimating [SIII] line strengths for high-redshift galaxies, a line that the James Webb Space Telescope will measure out to z~5.5

A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies

We assessed the sustained delivery effect of poly (lactic-co-glycolic) acid (PLGA)/vitamin E (VitE) microspheres (MSs) loaded with glial cell-derived neurotrophic factor (GDNF) alone (GDNF-MSs) or combined with brain-derived neurotrophic factor (BDNF; GDNF/BDNF-MSs) on migration of the human adult retinal pigment epithelial cell-line-19 (ARPE-19) cells, primate choroidal endothelial (RF/6A) cells, and the survival of isolated mouse retinal ganglion cells (RGCs). The morphology of the MSs, particle size, and encapsulation efficiencies of the active substances were evaluated. In vitro release, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability, terminal deoxynucleotidyl transferase (TdT) deoxyuridine dUTP nick-end labelling (TUNEL) apoptosis, functional wound healing migration (ARPE-19; migration), and (RF/6A; angiogenesis) assays were conducted. The safety of MS intravitreal injection was assessed using hematoxylin and eosin, neuronal nuclei (NeuN) immunolabeling, and TUNEL assays, and RGC in vitro survival was analyzed. MSs delivered GDNF and co-delivered GDNF/BDNF in a sustained manner over 77 days. The BDNF/GDNF combination increased RPE cell migration, whereas no effect was observed on RF/6A. MSs did not alter cell viability, apoptosis was absent in vitro, and RGCs survived in vitro for seven weeks. In mice, retinal toxicity and apoptosis was absent in histologic sections. This delivery strategy could be useful as a potential co-therapy in retinal degenerations and glaucoma, in line with future personalized long-term intravitreal treatment as different amounts (doses) of microparticles can be administered according to patients’ needs

Delivery of drinking, eating and mobilising (DrEaMing) and its association with length of hospital stay after major noncardiac surgery: observational cohort study

BACKGROUND: Enhanced recovery pathways are associated with improved postoperative outcomes. However, as enhanced recovery pathways have become more complex and varied, compliance has reduced. The ‘DrEaMing’ bundle re-prioritises early postoperative delivery of drinking, eating, and mobilising. We investigated relationships between DrEaMing compliance, postoperative hospital length of stay (LOS), and complications in a prospective multicentre major surgical cohort. METHODS: We interrogated the UK Perioperative Quality Improvement Programme dataset. Analyses were conducted in four stages. In an exploratory cohort, we identified independent predictors of DrEaMing. We quantified the association between delivery of DrEaMing (and its component variables) and prolonged LOS in a homogenous colorectal subgroup and assessed generalisability in multispecialty patients. Finally, LOS and complications were compared across hospitals, stratified by DrEaMing compliance. RESULTS: The exploratory cohort comprised 22 218 records, the colorectal subgroup 7230, and the multispecialty subgroup 5713. DrEaMing compliance was 59% (13 112 patients), 60% (4341 patients), and 60% (3421), respectively, but varied substantially between hospitals. Delivery of DrEaMing predicted reduced odds of prolonged LOS in colorectal (odds ratio 0.51 [0.43–0.59], P<0.001) and multispecialty cohorts (odds ratio 0.47 [0.41–0.53], P<0.001). At the hospital level, complications were not the primary determinant of LOS after colorectal surgery, but consistent delivery of DrEaMing was associated with significantly shorter LOS. CONCLUSIONS: Delivery of bundled and unbundled DrEaMing was associated with substantial reductions in postoperative LOS, independent of the effects of confounder variables. Consistency of process delivery, and not complications, predicted shorter hospital-level LOS. DrEaMing may be adopted by perioperative health systems as a quality metric to support improved patient outcomes and reduced LOS

Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study

Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. METHODS: Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. RESULTS: Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. CONCLUSIONS: The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity