Theoretical and experimental approach for the study of 2,4-dichlorophenoxyacetic acid photodegradation: C-O versus C-Cl bond dissociation energies in the gas phase and aqueous medium

International audienc

PET C-11 acetate is also a perfusion tracer for kidney evaluation purposes

International audienceRationale: Renal positron emission tomography (PET) functional imaging allows non-invasive and dynamic measurements of functional and metabolic parameters. [O-15]H2O is used as a perfusion tracer, and [C-11]acetate as an oxidative metabolism in this purpose, requiring two injections to assess those fundamental parameters. Yet, in cardiac physiology study, the high first-pass myocardial extraction fraction of [C-11]acetate allowed to use its influx rate as a blood flow marker too. Since [C-11]acetate has been characterized by a 20-25% single pass renal extraction in dogs, it could be used as a potential tracer for renal perfusion. The aim of this study was to determine whether [C-11]acetate influx rate can be used as quantitative in vivo marker of kidney perfusion in human. Methods: In 10 healthy subjects, dynamic PET acquisitions were performed after [O-15]H2O and [C-11]acetate injections spaced by a 15-minute interval. As previously validated, with compartmental modeling of kinetics, renal perfusion and oxidative metabolism were estimated respectively with influx rate of [O-15]H2O and efflux rate of [C-11]acetate. Additionally, influx rate of [C-11]acetate was regressed to influx rate of [O-15]H2O. Results: Renal time activity curves of [C-11]-acetate was best fitted with a mono compartmental model compared to a bi-compartmental model (p \textless 0.0001). [C-11]acetate influx rate was significantly correlated with perfusion quantified with [O-15]H2O (r(2) = 0.37, p \textless 0.001) at baseline. This regression allowed the computation of a renal [C-11]acetate extraction fraction (EF), and further the computation of renal blood flow from its influx rate. Conclusion: In healthy subjects, over a wide range of renal perfusion, direct estimates of renal oxygen consumption as well as tissue perfusion can be obtained by PET with a single tracer [C-11]acetate. This approach needs to be validated in CKD patients, and would be of great interest to design clinical protocol aiming at evaluating ischemic nephropathies candidate to revascularization. (C) 2019 Elsevier Inc. All rights reserved

Long-term Temperature Monitoring in CMS using Fiber Optic Sensors

In this paper, the results of the long-term temperature monitoring of the compact muon solenoid experiment (CMS) at CERN are shown. The measurements were carried out by means of a system based on fiber Bragg grating (FBG) sensors in wavelength-division multiplexing (WDM). Due to the harsh working conditions at the CMS, the FBG sensor represents the ideal candidate to realize a reliable and accurate sensing system. The sensing principles of the FBG sensor and its temperature characteristics are introduced. A temperature monitoring system based on FBG for high-energy physics applications is designed and installed. The sensing system was used successfully last year in monitoring the temperature of CMS bulkhead. The reported results show good reliability and high accuracy of the FBG sensing system during the long-time working stage

Fiber optic sensors structural monitoring of the beam pipe in the CMS experiment at the CERN

In this paper, the results of the temperature and strain monitoring of the central beam pipe of the Compact Muon Solenoid Experiment (CMS) at CERN are presented. The measurements are carried out by means of a system of Fiber Bragg Grating (FBG) sensor arrays glued on the central Beam Pipe of CMS. The system consisting of FBG sensors represents the ideal solution to manufacture a reliable and accurate sensing system to be used 24/7 in the harsh environment in CMS. The sensing principles of the FBG sensor and its temperature characteristics are introduced. First temperature and strain measurements data are presented. They were recorded during last period of CMS maintenance and first period of LHC collision started in April 2015

Fiber Bragg Grating Sensors as Innovative Monitoring Tool for Beam Induced RF Heating on LHC Beam Pipe

The i-pipe system is a peculiar structural health monitoring system, based on Fiber Bragg Grating technology, installed on the central beam pipe of the compact Muon solenoid (CMS) experiment at CERN. In this contribution, i-pipe temperature sensors, originally conceived as thermal compensator for the strain sensors, are employed to monitor central beam pipe thermal behavior in correlation with the parameters of the particle beam travelling inside, in order to directly measure possible Beam RF induced heating effect. The i-pipe system turned out to be capable of monitoring, directly and without interference, the parameters of the particle beam circulating in the LHC ring. Hence, the results presented in this work pave the way to the use of the i-pipe as monitoring system of an accelerated high energy particle beam