The switch from patented medicine to the generic one: an option or a necessity?

This paper assesses the influence of a number of factors taken into account when a brand name drug is replaced by a generic one. It also evaluates responses of health professionals – physicians and pharmacist—and patients regarding the issue of switching. We compared and contrasted their responses in order to identify new points of cooperation for the intended benefit of the patient. Thus, the sample drew from all three groups, consisting of 50 doctors, 50 pharmacists, and 50 patients. We collected information regarding the age, residence, income level, and education level for the patients, and age and experience for the specialists. Based on responses to the survey, replacing the original medication with a generic one raises many issues, such as lack of information for the patient and specialist, lack of collaboration between physician and pharmacist, ineffective communication between specialist and patient, and the influence of the overall profit motive

Biological therapy in the treatment of melanoma

Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable results. This therapy is based on stimulation of the immune system to fight tumoral cells through: injection of cytokines with immunomodulatory properties (interleukin-2, alpha-interferon), vaccination with tumor antigens or immune cells that process tumor antigens, adoptive immunotherapy, inhibition of immune checkpoints (PD-1, CTLA-4), inhibition or stimulation of immune modulator molecules (OX-40, LAG-3), inhibition of signaling pathways involved in cell proliferation (Raf/MAPK/ERK signaling pathway), or administration of oncolytic viruses. Biological therapy in melanoma has shown promise in laboratory and clinical studies, with more therapeutic targets to be revealed as new molecular and cellular mechanisms of the disease are discovered

Insights into mesh placement in contaminated surgical fields for abdominal wall repair – from prohibition to possibility

Surgical field contamination is a critical concern during abdominal wall prosthetic repair, as it significantly affects the risk of postoperative infections. This review paper combines an extensive analysis of relevant literature with personal experience to explore the challenges and advancements in the placement of mesh in contaminated surgical fields for the management of abdominal wall defects. Historically, the presence of any surgical field contamination was considered a contraindication for prosthetic placement due to the high risk of infection. However, with evolving understanding of the physiology and pathophysiology of biologic reaction around the mesh, as well as the development of various mesh types, the landscape has changed. The emerging understanding of hostmesh interaction, biofilm formation, and local tissue response has contributed to the development of innovative mesh designs that improve outcomes in challenging surgical scenarios. With meticulous surgical technique, adherence to infection prevention protocols, and the appropriate choice of mesh, successful abdominal wall prosthetic repair in contaminated fields is now feasible, opening new possibilities for patients with ventral and incisional hernias

The switch from patented medicine to the generic one: an option or a necessity?

This paper assesses the influence of a number of factors taken into account when a brand name drug is replaced by a generic one. It also evaluates responses of health professionals – physicians and pharmacist—and patients regarding the issue of switching. We compared and contrasted their responses in order to identify new points of cooperation for the intended benefit of the patient. Thus, the sample drew from all three groups, consisting of 50 doctors, 50 pharmacists, and 50 patients. We collected information regarding the age, residence, income level, and education level for the patients, and age and experience for the specialists. Based on responses to the survey, replacing the original medication with a generic one raises many issues, such as lack of information for the patient and specialist, lack of collaboration between physician and pharmacist, ineffective communication between specialist and patient, and the influence of the overall profit motive

Biological therapy in the treatment of melanoma

Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable results. This therapy is based on stimulation of the immune system to fight tumoral cells through: injection of cytokines with immunomodulatory properties (interleukin-2, alpha-interferon), vaccination with tumor antigens or immune cells that process tumor antigens, adoptive immunotherapy, inhibition of immune checkpoints (PD-1, CTLA-4), inhibition or stimulation of immune modulator molecules (OX-40, LAG-3), inhibition of signaling pathways involved in cell proliferation (Raf/MAPK/ERK signaling pathway), or administration of oncolytic viruses. Biological therapy in melanoma has shown promise in laboratory and clinical studies, with more therapeutic targets to be revealed as new molecular and cellular mechanisms of the disease are discovered

The switch from patented medicine to the generic one: an option or a necessity?

This paper assesses the influence of a number of factors taken into account when a brand name drug is replaced by a generic one. It also evaluates responses of health professionals – physicians and pharmacist—and patients regarding the issue of switching. We compared and contrasted their responses in order to identify new points of cooperation for the intended benefit of the patient. Thus, the sample drew from all three groups, consisting of 50 doctors, 50 pharmacists, and 50 patients. We collected information regarding the age, residence, income level, and education level for the patients, and age and experience for the specialists. Based on responses to the survey, replacing the original medication with a generic one raises many issues, such as lack of information for the patient and specialist, lack of collaboration between physician and pharmacist, ineffective communication between specialist and patient, and the influence of the overall profit motive

How much do Romanian medical students know about research ethics? A survey

Background: Although scientific research in Romania has continued to expand over the past 20 years, it is unclear how prepared the country’s students are to be involved in research and to publish the results of their work.Objectives: To assess Romanian medical students’ level of knowledge about research integrity and research ethics.Methods: A cross-sectional survey of 187 medical students (of which 70% were women) from Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, was performed between September 2017 and June 2018. The survey consisted of self-evaluation with respect to three aspects, namely knowledge of research in general, that of research integrity, and that of publication integrity. The self-evaluation was followed by a set of 17 questions that tested the respondent’s knowledge.Results: On average, the proportion of correct answers was 34% (range, 12%–65%). Whereas those who had assigned low grades to themselves (a score below 5) fared poorly (fewer correct answers) in the test that followed, those who rated themselves highly (a score of 5 or higher) did not fare as well as they were expected to. The majority of respondents (83%) were willing to learn more about research integrity through courses, workshops, training programmes, etc.Conclusion: The respondents showed a low level of knowledge related to both research integrity and current standards of reporting scientific research. This lacuna demonstrates the need to train students at the beginning of their academic life because more and more of them, both undergraduate and postgraduate, are likely to be involved in scientific research

Plagiarism detection in manuscripts submitted to the Journal of Surgical Sciences between 2020 and 2021: a case study

The aim of this study was to share our experience with plagiarism detection in manuscripts submitted to the Journal of Surgical Sciences, a Romania-based medical journal, between 2020 and 2021. We analyzed similarity score reports from 200 articles submitted consecutively for publication between 2020 and 2021 generated by PlagScan, a software tool for plagiarism detection. The similarity score ranged from 0% to 92.4%, and 45 articles presented scores over 25.0%. According to PlagScan’s results, more than half of the submitted articles had a similarity score of more than 10% and one-third of them had a similarity score above 20%. Among submitted manuscripts with a similarity score of less than 20%, a larger proportion of the original research and review manuscripts than case reports used more than 10 sources. All articles with a similarity score below 20% were evaluated qualitatively before the final decision of rejection

Abdominal Compartment Syndrome—When Is Surgical Decompression Needed?

Compartment syndrome occurs when increased pressure inside a closed anatomical space compromises tissue perfusion. The sudden increase in pressure inside these spaces requires rapid decompression by means of surgical intervention. In the case of abdominal compartment syndrome (ACS), surgical decompression consists of a laparostomy. The aim of this review is to identify the landmarks and indications for the appropriate moment to perform decompression laparotomy in patients with ACS based on available published data. A targeted literature review was conducted on indications for decompression laparotomy in ACS. The search was focused on three conditions characterized by a high ACS prevalence, namely acute pancreatitis, ruptured abdominal aortic aneurysm and severe burns. There is still a debate around the clinical characteristics which require surgical intervention in ACS. According to the limited data published from observational studies, laparotomy is usually performed when intra-abdominal pressure reaches values ranging from 25 to 36 mmHg on average in the case of acute pancreatitis. In cases of a ruptured abdominal aortic aneurysm, there is a higher urgency to perform decompression laparotomy for ACS due to the possibility of continuous hemorrhage. The most conflicting recommendations on whether surgical treatment should be delayed in favor of other non-surgical interventions come from studies involving patients with severe burns. The results of the review must be interpreted in the context of the limited available robust data from observational studies and clinical trials

Modelling the COVID-19 Pandemic Effects on Employees’ Health and Performance: A PLS-SEM Mediation Approach

The COVID-19 pandemic has resulted in the imposition of certain changes in the management of organizations and in the behavior and actions of employees. The purpose of this paper is to investigate the impact of COVID-19 pandemic effects on employees’ health and mental well-being, as well as on their working performance. Moreover, the paper aims to highlight whether health- and work-related stress factors mediate the above relations. For the purpose of data collection, a structured questionnaire was used. The first results of the study showed that the pandemic effects felt by employees did not directly affect their mental and physical well-being. On the other hand, the COVID-19 pandemic effects felt by employees affected their general work performance. The findings of the study may provide a useful perspective for organizations and their employees in order to adopt the most effective measures to minimize the effects generated by the pandemic