24 research outputs found
Resolution of vitreomacular traction following intravitreal ranibizumab in cases of ocular toxoplasmosis with choroidal neovascularization
Can solar neutrinos be a serious background in direct dark matter searches?
The coherent contribution of all neutrons in neutrino nucleus scattering due to the neutral current is examined considering the boron solar neutrinos. These neutrinos could potentially become a source of background in the future dark matter searches aiming at nucleon cross sections in the region well below the 10(-10) pb, i.e. a few events per ton per year
Correlation Between Optic Nerve Head Parameters, RNFL, and CCT in Patients with Bilateral Pseudoexfoliation Using HRT-III
Background: It is well-established that eyes with pseudoexfoliation
syndrome (PXS) have higher intraocular pressure (IOP). Early diagnosis
of preperimetric glaucoma will assist with better management of these
patients. The aim of this study is to evaluate the optic nerve head
(ONH) parameters and retinal nerve fiber layer (RNFL) thickness in
subjects with bilateral PXS, bilateral pseudoexfoliative glaucoma (PXG)
and normal, correlating these results with central corneal thickness
(CCT). Design: This is a cross-sectional, case control study. All
participants were from the Department of Ophthalmology, Athens
University Medical School. Participants: A total of 55 eyes from 55
patients with PXS (27 eyes from 27 patients with PXG and 28 eyes from 28
normal subjects) were studied. Methods: Topographic measurements of the
ONH and peripapillary RNFL thickness were performed using a confocal
scanning laser ophthalmoscope (the Heidelberg Retina Tomograph-III). The
outcomes were correlated with the CCT of the subjects. Main Outcome
Measures: PXS subjects and age-matched normal subjects did not differ
significantly in ONH parameters. RNFL thickness was significantly lower
in the PXS group compared with the normal group, but there was not a
statistically significant difference with the PXG patients. Regarding
the correlation with CCT, the PXG group showed negative correlation with
mean (p = 0.027) and max cup depth (p = 0.031), while PXS subjects
revealed a positive correlation with RNFL thickness (p = 0.032).
Conclusions: Our study showed that PXS subjects may be at greater risk
of RNFL thinning, presenting a statistically significant positive
association of the latter parameter with the CCT
Enlargement of the hypofluorescent post photodynamic therapy treatment spot after a combination of photodynamic therapy with an intravitreal injection of bevacizumab for retinal angiomatous proliferation
Background To report a case of enlargement of the post photodynamic
therapy treatment (PDT) spot in a patient with retinal angiomatous
proliferation (RAP) that was treated with PDT combined with an
intravitreal injection of bevacizumab.
Methods 74-year-old woman with RAP due to age-related macular
degeneration was treated with one verteporfin PDT session, sequenced by
a single intravitreal injection of bevacizumab (1.25 mg) after 30
minutes.
Results The patient’s visual acuity (VA) at baseline was 20/200 and is
now at the 10-month follow-up visit 20/400, while the RAP has
disappeared according to the indocyanine angiography (ICG) findings. The
post PDT hypofluorescent treatment spot has enlarged from 1,450 mu m at
the day of the treatment, to 5,360 mu m at the 6-week visit. The patient
is now at the 10-month follow-up visit and the hypofluorescence is still
persisting.
Conclusions The simultaneous combination of PDT with bevacizumab in
patients with RAP may enhance the photochemical stress in normal choroid
with prolonged and magnified hypofluorescence in ICG, due to ischemia in
normal choriocapillaries
A Generalised Regression algorithm for web page categorisation
This paper proposes an information system that classifies web pages according a taxonomy, which is mainly used from seven search engines/directories. The proposed classifier is a fourlayer Generalised Regression Neural Network (GRNN) that aims to perform the information segmentation according to information filtering techniques using content descriptor vectors. Eight categories of web pages were used in order to evaluate the robustness of the method, while no restrictions were imposed except for the language of the content, which is English. The system can be used as an assistant and consultative tool for classification purposes as well as for estimating the population of web pages at any given point in time
RANIBIZUMAB FOR THE TREATMENT OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION ASSOCIATED WITH RETINAL PIGMENT EPITHELIAL TEAR
Purpose: To evaluate the efficacy of intravitreal ranibizumab in eyes
with exudative age-related macular degeneration associated with retinal
pigment epithelial tear.
Methods: In this retrospective case series, patients with active
exudative age-related macular degeneration associated with retinal
pigment epithelial tear were treated by repeated injections of
intravitreal ranibizumab. The outcome measures were best-corrected
visual acuity and the signs of lesion activity, as evaluated by optical
coherence tomography, fluorescein angiography, and indocyanine green
angiography.
Results: Twenty-one eyes of 20 patients were followed-up for a median of
12 months (range, 6-28 months). The median number of injections was 7
(range, 3-15). The best-corrected visual acuity improved in 6 eyes
(28.57%), remained stable in 12 (57.14%), and decreased in 3
(14.28%). At the end of the follow-up time, 19 eyes (90.47%) had an
inactive neovascular lesion in angiography, while 18 eyes (85.71%) had
no signs of intraretinal or subretinal fluid.
Conclusion: Intravitreal ranibizumab was effective in improving or
stabilizing vision and resulting in a quiescent lesion in the majority
of patients with exudative age-related macular degeneration associated
with retinal pigment epithelial tear. The functional results were
apparently better in eyes without foveal involvement by the retinal
pigment epithelial tear. RETINA 31:1083-1088, 201
SAFETY OF REPEAT INTRAVITREAL INJECTIONS OF BEVACIZUMAB VERSUS RANIBIZUMAB Our Experience After 2,000 Injections
Purpose: To compare the safety of repeat intravitreal injections of
bevacizumab versus ranibizumab performed on a large series of patients
during the past 2 years period of time.
Methods: Four hundred fifty patients receiving 2,000 injections (1,275
bevacizumab and 725 ranibizumab) were studied retrospectively.
Injections performed in a usual examination room under the standard
sterile conditions. Follow-up varied from 3 to 24 months.
Results: Serious ocular adverse events were uncommon. Only one patient
developed retinal detachment (0.05%). Most common procedure-related
ocular adverse event was injection-site redness (64.75%). Postoperative
subconjuctival hemorrhage occurred after 200 (10%) injections. Patients
receiving aspirin treatment were more prone to have subconjuctival
hemorrhage (P = 0.0002). Most common drug-related ocular adverse event
was uveitis (1.90%), which was treated successfully and lasted no > 12
days. There was no statistically significant difference between the
patients treated with bevacizumab or ranibizumab regarding the noted
adverse events (P > 0.5%).
Conclusion: Multiple intravitreal injections of bevacizumab or
ranibizumab were both well tolerated and safe. Performing injections on
a usual examination room proved safe. Injection-site redness,
subconjuctival hemorrhage, and uveitis were the most common ocular
adverse events. Aspirin treatment was a risk factor for the development
of subconjuctival hemorrhage
The Wisconsin Breast Cancer Problem: Diagnosis and DFS time prognosis using
probabilistic and generalised regression neural classifier
PHOTODYNAMIC THERAPY, RANIBIZUMAB, AND RANIBIZUMAB WITH PHOTODYNAMIC THERAPY FOR THE TREATMENT OF POLYPOIDAL CHOROIDAL VASCULOPATHY
Purpose: The purpose of this study was to compare photodynamic therapy
(PDT), ranibizumab, and ranibizumab with PDT in polypoidal choroidal
vasculopathy.
Methods: In this retrospective comparative study, 30 eyes of 30 patients
with polypoidal choroidal vasculopathy were assigned to 1 of the 3
groups. The patients in Group 1 (n = 11) received 1 session of PDT. The
patients in Group 2 (n = 10) received 3 monthly intravitreal injections
of 0.5 mg ranibizumab, and the patients in Group 3 (n = 9) received 1
session of PDT and 3 injections of 0.5 mg ranibizumab. Retreatment, with
the same therapeutic scheme in each group, was considered in case of
leaking polyps on the indocyanine green angiography in Groups 1 and 3
and persistence or recurrence of subretinal fluid, intraretinal fluid,
and/or hemorrhages in Group 2.
Results: All the patients completed 12 months of follow-up. The visual
acuity in the patients of Group 1 improved by 0.25 logarithm of the
minimum angle of resolution units (P< 0.001), whereas the differences in
the visual acuity in the other 2 groups were not statistically
significant (0.04 logarithm of the minimum angle of resolution, P =
0.8118 in Group 2 and 0.18 logarithm of the minimum angle of resolution,
P> 0.05 in Group 3). Of the patients in Group 1, 45.45% gained more
than 3 lines (P = 0.0056), whereas no patient in Groups 2 and 3
experienced such a difference. No patient in Group 1 and 11.1% (n = 1)
in Group 3 had angiographically evident polyps at 12 months, whereas
90% (n = 9) of the patients in Group 2 had persistent leakage. No
extensive submacular hemorrhage or other complications were noted during
the follow-up period.
Conclusion: Photodynamic therapy resulted in a significantly better
outcome at the end of the follow-up, whereas the patients who received
ranibizumab or PDT and ranibizumab experienced a stabilization of the
disease. RETINA 31: 464-474, 201
Vitamin Status as a Determinant of Serum Homocysteine Concentration in Type 2 Diabetic Retinopathy
We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels P<0.001, higher prevalence of hyperhomocysteinemia P<0.001, lower serum folic acid P<0.001, and vitamin B12 (P=0.014) levels than those without diabetic retinopathy. Regression analysis revealed that homocysteine was an independent risk factor for diabetic retinopathy and there was a threshold in its serum level (13.7 μmol/L), above which the risk of diabetic retinopathy greatly increases (OR=1.66, P=0.001). Folic acid was associated with decreased odds for diabetic retinopathy (OR=0.73, P<0.001). There was a threshold in serum vitamin B12 level (248.4 pg/mL), below which serum homocysteine concentration significantly increases with decreasing serum vitamin B12 (P=0.003). Our findings suggest that hyperhomocysteinemia is an independent risk factor for the development and progression of diabetic retinopathy. Decreased serum levels of folic acid and vitamin B12, through raising serum homocysteine concentrations, may also affect the diabetic retinopathy risk