A Study of Information Fragment Association in Information Management and Retrieval Applications

As we strive to identify useful information sifting through the vast number of resources available to us, we often find that the desired information is residing in a small section within a larger body of content which does not necessarily contain similar information. This can make this Information Fragment difficult to find. A Web search engine may not provide a good ranking to a page of unrelated content if it contains only a very small yet invaluable piece of relevant information. This means that our processes often fail to bring together related Information Fragments. We can easily conceive of two Information Fragments which according to a scholar bear a strong association with each other, yet contain no common keywords enabling them to be collocated by a keyword search.This dissertation attempts to address this issue by determining the benefits of enhancing information management and retrieval applications by providing users with the capability of establishing and storing associations between Information Fragments. It estimates the extent to which the efficiency and quality of information retrieval can be improved if users are allowed to capture mental associations they form while reading Information Fragments and share these associations with others using a functional registry-based design. In order to test these benefits three subject groups were recruited and assigned tasks involving Information Fragments. The first two tasks compared the performance and usability of a mainstream social bookmarking tool with a tool enhanced with Information Fragment Association capabilities. The tests demonstrated that the use of Information Fragment Association offers significant advantages both in the efficiency of retrieval and user satisfaction. Analysis of the results of the third task demonstrated that a mainstream Web search engine performed poorly in collocating interrelated fragments when a query designed to retrieve the one of these fragments was submitted. The fourth task demonstrated that Information Fragment Association improves the precision and recall of searches performed on Information Fragment datasets.The results of this study indicate that mainstream information management and retrieval applications provide inadequate support for Information Fragment retrieval and that their enhancement with Information Fragment Association capabilities would be beneficial

X‐ray fluorescence spectroscopy of picrolite raw material on Cyprus

Picrolite artefacts comprise some of the most distinctive material remains in the prehistory of the island of Cyprus, in the Eastern Mediterranean. Picrolite exploitation dates from at least 12,000 years ago for the manufacture of personal ornaments and items with a symbolic function. It is commonly assumed that picrolite nodules were collected in secondary deposits on an ad hoc basis. This narrative, however, ignores the fact that picrolite carriers can only be found in very specific locations on the island, discrete from each other. Here we report initial outcomes of the application of handheld portable X-ray fluorescence (HHpXRF) and synchrotron-based X-ray fluorescence spectroscopy (SR-μXRF) to the analysis of picrolite raw materials performed at the newly opened PUMA beamline of the SOLEIL Synchrotron Radiation Facility. Our work refines the basic characteristics of the elemental constituents of the picrolite raw material and highlights key micro-structural differences between two distinct source regions on the Troodos Massif in western Cyprus. Picrolite source characterisation is expected to contribute significant new knowledge to the study of rare raw material consumption, prehistoric social organisation, networking and possible long-distance exchange of this idiosyncratic raw material within and beyond the island’s geographic boundaries

MEG Network Differences between Low- and High-Grade Glioma Related to Epilepsy and Cognition

OBJECTIVE: To reveal possible differences in whole brain topology of epileptic glioma patients, being low-grade glioma (LGG) and high-grade glioma (HGG) patients. We studied functional networks in these patients and compared them to those in epilepsy patients with non-glial lesions (NGL) and healthy controls. Finally, we related network characteristics to seizure frequency and cognitive performance within patient groups. METHODS: We constructed functional networks from pre-surgical resting-state magnetoencephalography (MEG) recordings of 13 LGG patients, 12 HGG patients, 10 NGL patients, and 36 healthy controls. Normalized clustering coefficient and average shortest path length as well as modular structure and network synchronizability were computed for each group. Cognitive performance was assessed in a subset of 11 LGG and 10 HGG patients. RESULTS: LGG patients showed decreased network synchronizability and decreased global integration compared to healthy controls in the theta frequency range (4-8 Hz), similar to NGL patients. HGG patients' networks did not significantly differ from those in controls. Network characteristics correlated with clinical presentation regarding seizure frequency in LGG patients, and with poorer cognitive performance in both LGG and HGG glioma patients. CONCLUSION: Lesion histology partly determines differences in functional networks in glioma patients suffering from epilepsy. We suggest that differences between LGG and HGG patients' networks are explained by differences in plasticity, guided by the particular lesional growth pattern. Interestingly, decreased synchronizability and decreased global integration in the theta band seem to make LGG and NGL patients more prone to the occurrence of seizures and cognitive decline

A STUDY OF INFORMATION FRAGMENT ASSOCIATION IN INFORMATION MANAGEMENT AND RETRIEVAL APPLICATIONS

This dissertation was presented b

Calcipotriol/betamethasone dipropionate in the treatment of psoriasis vulgaris

Efstratios Vakirlis, Athanasios Kastanis, Demetrios IoannidesA’ Department of Dermatology, Aristotle University of Thessaloniki, GreeceAbstract: Psoriasis is one of the most common skin diseases. The mainstay of treatment for the vast majority of patients is topical therapy. A rising first-line treatment modality for psoriasis vulgaris is the two-compound ointment containing calcipotriol 50 µg/g plus betamethasone dipropionate 0.5 mg/g (Dovobet®, Daivobet®, Taclonex®), which combines a vitamin D analog and a corticosteroid. This innovative formulation preserves the activity and bioavailability of the two components and many clinical studies have demonstrated that it has a greater efficacy, tolerability, and a rapid onset of action compared with its individual ingredients or tacalcitol.Keywords: psoriasis, calcipotriol/betamethasone dipropionate, dovobet, daivobet, taclone