OpenStack Evaluation Report

The Technology Investigation Service's Technology Evaluation team conducted an evaluation of OpenStack. This report summarizes their findings.National Science Foundation OCI-1053575Ope

Xrdp Remote Desktop Solution Evaluation Report

The Technology Investigation Service's Technology Evaluation team conducted an evaluation of the XRDP remote terminal tool. This report summarizes their findings.National Science Foundation OCI-1053575Ope

Duo Security Evaluation Public Report

The Technology Investigation Service's Technology Evaluation team conducted an evaluation of the DUO One Time Password (OTP) tool. This public report summarizes their findings.National Science Foundation OCI-1053575Ope

XSEDE Cloud VM Repository

The Technology Investigation Service's Technology Evaluation team produced a white paper to gather ideas for an XSED sponsored repository that would house VM's centrally. This report summarizes their findings.National Science Foundation OCI-1053575Ope

NoMachine Remote Access Evaluation Report

The Technology Investigation Service's Technology Evaluation team conducted an evaluation of the NoMachine remote desktop tool. This report summarizes their findings.National Science Foundation OCI-1053575Ope

Aspera Evaluation Report

The Technology Investigation Service's Technology Evaluation team conducted an evaluation of the Aspera file transfer tool. This report summarizes their findings.National Science Foundation OCI-1053575Ope

Bittorrent Sync Evaluation Public Report

The Technology Investigation Service's Technology Evaluation team conducted an evaluation of the BitTorrent file transfer tool. This report summarizes their findings.National Science Foundation OCI-1053575Ope

Evidence of widespread selection on standing variation in Europe at height-associated SNPs.

Strong signatures of positive selection at newly arising genetic variants are well documented in humans(1-8), but this form of selection may not be widespread in recent human evolution(9). Because many human traits are highly polygenic and partly determined by common, ancient genetic variation, an alternative model for rapid genetic adaptation has been proposed: weak selection acting on many pre-existing (standing) genetic variants, or polygenic adaptation(10-12). By studying height, a classic polygenic trait, we demonstrate the first human signature of widespread selection on standing variation. We show that frequencies of alleles associated with increased height, both at known loci and genome wide, are systematically elevated in Northern Europeans compared with Southern Europeans (P < 4.3 × 10(-4)). This pattern mirrors intra-European height differences and is not confounded by ancestry or other ascertainment biases. The systematic frequency differences are consistent with the presence of widespread weak selection (selection coefficients ∼10(-3)-10(-5) per allele) rather than genetic drift alone (P < 10(-15))

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

BackgroundRheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA). Until now, data from genome-wide association studies (GWAS) have only been published from ACPA-positive subsets of RA or from studies that have not separated the two subsets. The aim of the current study is to provide and compare GWAS data for both subsets.Methods and resultsGWAS using the Illumina 300K chip was performed for 774 ACPA-negative patients with RA, 1147 ACPA-positive patients with RA and 1079 controls from the Swedish population-based case-control study EIRA. Imputation was performed which allowed comparisons using 1,723,056 single nucleotide polymorphisms (SNPs). No SNP achieved genome-wide significance (2.9 × 10⁻⁸) in the comparison between ACPA-negative RA and controls. A case-case association study was then performed between ACPA-negative and ACPA-positive RA groups. The major difference in this analysis was in the HLA region where 768 HLA SNPs passed the threshold for genome-wide significance whereas additional contrasting SNPs did not reach genome-wide significance. However, one SNP close to the RPS12P4 locus in chromosome 2 reached a p value of 2 × 10⁶ and this locus can thus be considered as a tentative candidate locus for ACPA-negative RA.ConclusionsACPA-positive and ACPA-negative RA display significant risk allele frequency differences which are mainly confined to the HLA region. The data provide further support for distinct genetic aetiologies of RA subsets and emphasise the need to consider them separately in genetic as well as functional studies of this disease