Remote temperature profiling in the troposphere and stratosphere by the radio-acoustic sounding technique

Radar application of the radio-acoustic sounding technique uses the Doppler frequency shift of radar echoes returning from the atmospheric wave structure, in association with a traveling acoustic pulse transmitted from the ground, to determine the speed of sound, and hence the atmospheric temperature, as a function of altitude. Temperature measurement in the troposphere and stratosphere were determined using the radio-acoustic sounding technique with the Radio-Acoustic Sounding System (RASS). Successful experiments were performed in March 1985, and in August 1985

Structural realism and eternalism can solve the mind-brain problem

There are many theories concerning the mind-brain(mind-body) problem, but these theories have serious flaws because they view the problem as a relation between "mind" and "matter". This paper redefines the problem as a relation between "mind" and "reality" and attempts to solve the problem by combining structural realism and the eternalism of the philosophy of time

Gold(I)-Catalyzed Cascade Cyclization Reactions of Allenynes for the Synthesis of Fused Cyclopropanes and Acenaphthenes

A gold‐catalyzed reaction of phenylene‐tethered allenynes with benzofurans gave 1‐(naphth‐1‐yl)cyclopropa[b]benzofuran derivatives, whereas the reaction of 1‐allenyl‐2‐ethynyl‐3‐methylbenzene derivatives in the absence of benzofurans gave acenaphthenes in good yields. These results can be rationalized by nucleophilic attack of the alkyne moiety on an activated allene to form a vinyl cation intermediate

Kant's Antinomy proves Eternalism and Structural Realism true

Most mathematicians and many physicists believe that Zeno's paradox and Kant's antinomy were solved by Cantor and others, but this is a misunderstanding. This paper expose such misunderstanding. And once we accept the validity of Zeno's and Kant's arguments, we suggest that their paradoxes are resolved by structural realism and eternalism

Solid-state structure, solution-state behaviour and catalytic activity of electronically divergent C, N-chelating palladium-N-heterocyclic carbene complexes

A family of electronically diverse pyridyl- and picolyl-substituted imidazolium salts have been prepared and coordinated to palladium in a single step, to deliver a variety of palladium(II)–N-heterocyclic carbene (NHC) complexes. Neutral Pd(NHC)X2, cationic [Pd(NHC)2X]X and dicationic [Pd(NHC)2]X2-type complexes have been isolated and fully characterised, with single-crystal X-ray analysis revealing a variety of coordination environments around the palladium centres. The pre-formed complexes have been employed in a model Suzuki–Miyaura cross-coupling reaction to yield a sterically congested tetra-ortho-substituted biaryl product, showcasing turnover numbers comparable to Pd-PEPPSI-IPr catalyst

Gold(I)-Catalyzed Cascade Cyclization of Anilines with Diynes: Controllable Formation of Eight-Membered Ring-Fused Indoles and Propellane-Type Indolines

Heterocycle-fused indoles or indolines are distributed widely in a variety of natural products, bioactive agents, and pharmaceuticals. Herein, we describe the development of gold-catalyzed cascade reactions of anilines with diynes to form eight-membered ring-fused indoles and propellane-type indolines, both of which proceed through an intramolecular 5-endo-dig hydroamination followed by an 8-endo-dig cycloisomerization. Controllable formation of eight-membered ring-fused indoles and propellane-type indolines was achieved through selection of the ligands and/or solvents. Protic solvents such as alcohols or IPr ligand favored the formation of eight-membered ring-fused indoles, whereas the use of Buchwald’s type ligands and/or nonpolar solvents gave propellane-type indoline predominantly. This reaction provides rapid access to two types of fused nitrogen heterocycles from simple aniline derivatives

Total Synthesis of Zephycarinatines via Photocatalytic Reductive Radical ipso‐Cyclization

We report herein a nonbiomimetic strategy for the total synthesis of the plicamine‐type alkaloids zephycarinatines C and D. The key feature of the synthesis is a stereoselective reductive radical ipso‐cyclization using visible‐light‐mediated photoredox catalysis. This cyclization enabled the construction of a 6, 6‐spirocyclic core structure through the addition of a carbon‐centered radical onto the aromatic ring. Biological evaluation of zephycarinatines and their derivatives revealed that the synthetic derivative with a keto group displays moderate inhibitory activity against LPS‐induced NO production. This approach could offer future opportunities to expand the chemical diversity of plicamine‐type alkaloids as well as providing useful intermediates for their syntheses

Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state

妊娠中の女性ホルモンは胎児の栄養環境とその後の成長に影響する --mPRε受容体を標的とした妊娠糖尿病治療薬開発の可能性-- . 京都大学プレスリリース. 2025-03-17.Sex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of progesterone on the interaction between mother and embryo is unclear. Here, we demonstrate that the relationship between maternal progesterone and membrane progesterone receptor epsilon (mPRε) in adipose tissue regulates embryonic nutritional environment and growth after birth in mice. The activation of adipose mPRε by increased progesterone during pregnancy enhances maternal insulin resistance via prostaglandin production, efficiently providing glucose to embryos. Correspondingly, the offspring of mPRε-deficient mothers exhibited metabolic dysfunction, whereas mPRε-deficient mothers with high-fat diet-induced obesity exhibited improved insulin sensitivity. These findings establish the importance of progesterone as a nutritional regulator between mother and embryo. Additionally, mPRε may represent a modulator for treating pregnant glycemic control disorders such as gestational diabetes mellitus, as well as metabolic syndrome in offspring

一須賀G11号墳の測量調査

departmental bulletin pape