Organisation Kultur Geschlecht : Eine empirische Untersuchung zur (Geschlechts-)Sensibilität in und von Organisationen

Die vorliegende Arbeit trägt den Titel Organisation Kultur Geschlecht und basiert auf einer empirischen Untersuchung zur (Geschlechts-)Sensibilität in und von neun Organisationen aus dem wirtschaftlichen, öffentlichen und sozialen Bereich. Von Interesse sind Organisationen und ihre Besonderheiten in bezug auf Geschlecht, d.h. Strukturen (Geschlechterordnung) und Handlungsweisen (Geschlechterpraxis), die die Beachtung von Geschlecht und damit von Frauen und Männern in Organisationen bedingen und fördern. Die These der Geschlechtssensibilität von Organisationen wird zu einem zentralen Element der Sichtweise über Organisationen. Es stellen sich Fragen, wie gehen Organisationen mit Geschlecht um (Geschlechtsblindheit), wo werden in der Konstruktion von Geschlecht Bereiche der Sensibilität erkenn- und wahrnehmbar, welche Strategien entwickeln Organisationen in anbetracht von Forderungen, sensibel gegenüber der Ungleichheit zwischen Frauen und Männern zu werden und aktiv für Frauen- und Geschlechterförderung einzutreten (Geschlechterprogramme). Die Arbeit liefert einen theoretischen Ansatz, der von systemtheoretischen und unternehmenskulturellen Überlegungen getragen wird sowie von Erkenntnissen aus der konstruktivistisch-orientierten Geschlechterforschung. Das Forschungsprogramm (Konstruktivistisches Denken und Ethnographisches Sehen) leitet den empirischen Zugang (Empirisches Handeln) zur Welt von Organisationen (Kosmographie). In der Forschungsreise, die in der Arbeit beschrieben ist, werden Sensibilitäten der Organisationen identifiziert und in den Organisationsbereichen Förderung, Zeit und Raum beschrieben.This work, addressed to the complex project „Organization Culture Gender“, is based on an empirical study about the (gender-)sensitivity in and of nine organizations within the economical, social and civil service field. The focus of our study lies on organizations and their special characteristics with reference to gender, i. e. structures (gender-order) und activities (gender-practice), which have intended or unintended effects to the way of regarding gender and therefore women and men in organizations. Addressing the hypothesis, that organizations are highly gender-sensible, has become a central element in the view of organizations. We are looking for answers to questions like: how do organizations deal with gender (gender-blindness), where are visible and recognizable (social construction of gender) areas of sensitivity in the organization, which organizational strategies are developed, also in face of the claims, to become sensitive to the inequality between women and men in organizations, or to engage in special promotion of women and gender (gender-programs). This work is embedded in a theoretical approach which links reflections of system and organizational culture theory and findings of gender research based on constructivism. The program of research (constructivistic thinking and ethnographic seeing) guides the empirical approach (empirical work) to the world of organizations (cosmography). In the research voyage sensitivities of the organizations are identified and described in the organi-zational areas of support, time and space

[Stammbuch Ingeborg Franke]

[STAMMBUCH INGEBORG FRANKE] [Stammbuch Ingeborg Franke] (1) Einband (1) Einträge Bl. 1 - 31 (8) Einlage: "Einlieferungsschein" (25

The Prognostic Role of Global Longitudinal Strain and NT-proBNP in Heart Failure Patients Receiving Cardiac Resynchronization Therapy

Background: We aimed to evaluate whether baseline GLS (global longitudinal strain), NT-proBNP, and changes in these after cardiac resynchronization therapy (CRT) can predict long-term clinical outcomes and the echocardiographic-based response to CRT (defined by 15% relative reduction in left ventricular end-systolic volume). Methods: We enrolled 143 patients with stable ischemic heart failure (HF) undergoing CRT-D implantation. NT-proBNP and echocardiography were obtained before and 6 months after. The patients were followed up (median: 58 months) for HF-related deaths and/or HF hospitalizations (primary endpoint) or HF-related deaths (secondary endpoint). Results: A total of 84 patients achieved the primary and 53 the secondary endpoint, while 104 patients were considered CRT responders and 39 non-responders. At baseline, event-free patients had higher absolute GLS values (p p p = 0.002) was beneficially associated with lower primary endpoint incidence, while baseline NT-proBNP levels (HR = 1.55; 95% CI, 1.43–2.01; p = 0.002) and diabetes presence (HR = 1.27; 95% CI, 1.12–1.98; p = 0.003) were related to higher primary endpoint incidence. Conclusions: In HF patients undergoing CRT-D, baseline GLS and NT-proBNP concentrations may serve as prognostic factors, while they may predict the echocardiographic-based response to CRT

Glenoid morphology in light of anatomical and reverse total shoulder arthroplasty: a dissection- and 3D-CT-based study in male and female body donors

Abstract Background Placement of the glenoid baseplate is of paramount importance for the outcome of anatomical and reverse total shoulder arthroplasty. However, the database around glenoid size is poor, particularly regarding small scapulae, for example, in women and smaller individuals, and is derived from different methodological approaches. In this multimodality cadaver study, we systematically examined the glenoid using morphological and 3D-CT measurements. Methods Measurements of the glenoid and drill hole tunnel length for superior baseplate screw placement were recorded to define size of the glenoid and the distance to the scapular notch on cadaveric specimens. Glenoid angles were determined on both, 3D-CT-scans of the thoraxes using the Friedman method and on subsequently isolated scapulae from 18 male and female donors (average 84\ua0years, range 60\u201398 years). Results Mean glenoid height was 36.6\ua0mm\u2009\ub1\u20093.6, and width 27.8\ua0mm\u2009\ub1\u20093.1 with a significant sex dimorphism ( p \u2009\u2264\u20090.001): in males, glenoid height 39.5\ua0mm\u2009\ub1\u20093.5, and width 30.3\ua0mm\u2009\ub1\u20093.3, and in females, glenoid height 34.8\ua0mm\u2009\ub1\u20092.2, and width 26.2\ua0mm\u2009\ub1\u20091.6. The average distance from the superior screw entry to its exit in the scapular notch measured by calliper was 27.2\ua0mm\u2009\ub1\u20096.0 with a sex difference: in males, 29.4\ua0mm\u2009\ub1\u20095.7, and in females, 25.8\ua0mm\u2009\ub1\u20095.9\ua0mm with a minimum recorded distance of 15\ua0mm. Measured by CT, the mean inclination angle for male and female donors combined was 13.0\ub0\u2009\ub1\u20097.0, and the ante-/retroversion angle \u22121.0\ub0\u2009\ub1\u20094.0\ub0. Conclusion This study is one of the first to ..

Whole-genome sequencing reveals host factors underlying critical COVID-19

Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease