765 research outputs found
4-(4-Chlorophenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione
The title compound, 4-(4-chlorophenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione (1), was synthesized by a hetero-cyclization reaction of 4-chlorophenyl isothiocyanate and formic hydrazide. Compound 1 was characterized by a single-crystal X-ray structure determination as well as 1H and 13C{1H} NMR, IR, and UV spectroscopy, and microelemental analysis. X-ray crystallography on 1 confirms the molecule exists as the thione tautomer and shows the five-membered ring to be planar and to form a dihedral angle of 82.70(5)° with the appended chlorophenyl ring, indicating an almost orthogonal relationship. In the molecular packing, supramolecular dimers are formed via thioamide-N–H⋯S(thione) hydrogen bonds and these are connected by C=S⋯π(triazolyl) and C-Cl⋯π(triazolyl) interactions, leading to a three-dimensional architectur
Age and sex comparison in determining baseline blood and coagulation profiles in semi-extensive Rusa deer (Rusa timorensis)
The objective of the study was to establish the baseline values for blood and coagulation parameters in normaland healthy rusa deer (Rusa timorensis) of different ages and sexes. The sample population consists of 40 rusa deer, divided into four groups of (i) juvenile males (ii) juvenile females (iii) adult males and (iv) adult
females. The findings showed significant (p<0.05) higher values in erythrocyte count, calcium concentration and prothrombin
time in the adult males compared to adult female rusa deer. On the other hand, the total protein concentration was significantly
higher in adult females than adult male deer. No significant differences in blood or coagulation parameters were observed
between sexes in the juvenile deer. Between age group, the adult deer had significantly higher mean cell volume, plasma protein
and globulin concentration than juvenile rusa deer. Thus, it is necessary to take into account the age and sex of the rusa deer
when using blood reference values for the diagnosis of diseases or health assessment
Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele.
BACKGROUND: Meningomyelocele (MM) results from lack of closure of the neural tube during embryologic development. Periconceptional folic acid supplementation is a modifier of MM risk in humans, leading toan interest in the folate transport genes as potential candidates for association to MM.
METHODS: This study used the SNPlex Genotyping (ABI, Foster City, CA) platform to genotype 20 single polymorphic variants across the folate receptor genes (FOLR1, FOLR2, FOLR3) and the folate carrier gene (SLC19A1) to assess their association to MM. The study population included 329 trio and 281 duo families. Only cases with MM were included. Genetic association was assessed using the transmission disequilibrium test in PLINK.
RESULTS: A variant in the FOLR2 gene (rs13908), three linked variants in the FOLR3 gene (rs7925545, rs7926875, rs7926987), and two variants in the SLC19A1 gene (rs1888530 and rs3788200) were statistically significant for association to MM in our population.
CONCLUSION: This study involved the analyses of selected single nucleotide polymorphisms across the folate receptor genes and the folate carrier gene in a large population sample. It provided evidence that the rare alleles of specific single nucleotide polymorphisms within these genes appear to be statistically significant for association to MM in the patient population that was tested
Superheated Microdrops as Cold Dark Matter Detectors
It is shown that under realistic background considerations, an improvement in
Cold Dark Matter sensitivity of several orders of magnitude is expected from a
detector based on superheated liquid droplets. Such devices are totally
insensitive to minimum ionizing radiation while responsive to nuclear recoils
of energies ~ few keV. They operate on the same principle as the bubble
chamber, but offer unattended, continuous, and safe operation at room
temperature and atmospheric pressure.Comment: 15 pgs, 4 figures include
Anomalous finite-size effect in superconducting Josephson junction arrays
We report large-scale simulations of the resistively-shunted Josephson
junction array in strip geometry. As the strip width increases, the voltage
first decreases following the dynamic scaling ansatz proposed by Minnhagen {\it
et al.} [Phys. Rev. Lett. {\bf 74}, 3672 (1995)], and then rises towards the
asymptotic value predicted by Ambegaokar {\it et al.} [Phys. Rev. Lett. {\bf
40}, 783 (1978)]. The nonmonotonic size-dependence is attributed to shortened
life time of free vortices in narrow strips, and points to the danger of
single-scale analysis applied to a charge-neutral superfluid state.Comment: 4 pages, 2 figure
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