El Modelo Social Europeo entre la modernización competitiva y la resistencia frente al neoliberalismo

El concepto de modelo social europeo es una cuestión recurrente en el discurso europeísta. En este artículo se describe la importante mutación que ha tenido este concepto en las dos últimas décadas. Mientras en un principio se creó para representar la visión de una Europa socialdemócrata realizada por Delors, se ha ido decantando progresivamente como una forma de legitimación del proceso de integración neoliberal, así como para justificar el recorte de los sistemas de bienestar. A pesar de todo, se mantiene la popularidad del modelo social europeo como una alternativa al modelo de capitalismo estadounidense de libre mercado. Por esto la izquierda sigue utilizando el concepto para formular una propuesta de alternativa europea.política social, discurso europeísta, neoliberalismo, conflicto social

Impact of the dynamics of the catalytic arginine on nitrite and chlorite binding by dimeric chlorite dismutase

Open access version published by the EditorIlenia Serra & Daniel Schmidt contributed equally to this manuscrip

Immature Osteoblast Lineage Cells Increase Osteoclastogenesis in Osteogenesis Imperfecta Murine

This study addressed the role of impairment of osteoblastic differentiation as a mechanism underlying pathophysiology of the osteogenesis imperfecta (OI). We hypothesized that combination of impaired osteogenic differentiation with increased bone resorption leads to diminished bone mass. By introducing visual markers of distinct stages of osteoblast differentiation, pOBCol3.6GFP (3.6GFP; preosteoblast) and pOBCol2.3GFP (2.3GFP; osteoblast/osteocytes), into the OIM model, we assessed osteoblast maturation and the mechanism of increased osteoclastogenesis. Cultures from oim/oim;2.3GFP mice showed a marked reduction of cells expressing GFP relative to +/+;2.3GFP littermates. No significant difference in expression of 3.6GFP between the +/+ and oim/oim mice was observed. Histological analysis of the oim/oim;3.6GFP mice showed an increased area of GFP-positive cells lining the endocortical surface compared with +/+;3.6GFP mice. In contrast GFP expression was similar between oim/oim;2.3GFP and +/+;2.3GFP mice. These data indicate that the osteoblastic lineage is under continuous stimulation; however, only a proportion of cells attain the mature osteoblast stage. Indeed, immature osteoblasts exhibit a stronger potential to support osteoclast formation and differentiation. We detected a higher Rankl/Opg ratio and higher expression of TNF-α in sorted immature osteoblasts. In addition, increased osteoclast formation was observed when osteoclast progenitors were cocultured with oim/oim-derived osteoblasts compared with osteoblasts derived from +/+ mice. Taken together, our data indicate that osteoblast lineage maturation is a critical aspect underlying the pathophysiology of OI