Assessment of stress, anxiety, and depression among the nursing personnel employed in tertiary care hospital during COVID-19 pandemic

Background: Work related stress is an important occupational hazard among the forefront healthcare workers like nursing personnel. It is their demanding nature of occupation which exposes them to a higher risk of developing negative mental states. Aims and Objectives: Objectives of the study were to assess the stress, anxiety, and depression among the nursing personnel and their potential risk factors for stress, anxiety, and depression. Materials and Methods: A descriptive observational study was conducted among the nursing personnel employed in a tertiary care hospital in Kolkata. The data collection was done with the help of a predesigned pretested semi-structured questionnaire having information regarding socio demographic profile, history and personal history, and the questions from depression, anxiety and stress scale following permission from Institutional Ethics committee. The data were compiled, analyzed, and presented. Results: The present study found that 29.09%, 40% and 33.64% of the study subjects were suffering from depression, anxiety, and stress, respectively. Nuclear families, staying at hostel, nonspecific symptoms, COVID-19 exposure, and nonspecific symptoms were significant contributing factors for depression. COVID-19 exposure was significantly associated with anxiety. Nuclear families, presence of nonspecific symptoms were significant contributing factor for stress. No significant association was found with age, educational level, marital status, leisure activity, chronic morbidity, testing, and quarantine. Conclusion: Early assessment of the occupational stress, anxiety, and depression among the nursing personnel can initiate targeted intervention strategies. This would improve their personal and professional quality of life which affects the quality of health-care service

Dried tuna for export as a small scale industry in Andhra Pradesh

Yellowfin tuna (Thunnus albacares) formed an average 33.5% of the total tuna catch of Andhra Pradesh, during the past decade. Fishing grounds for yellowfin tuna off northern Andhra Pradesh at depths of 200 m and more are gainfully exploited by the local fishers since 2002 using motorized crafts (theppas) with hooks and lines and trolls. Since 2006 a few mechanized trawlers were also converted to long liners for catching tunas

Marine Fishery Resources of Andhra Pradesh

Andhra Pradesh with a coastline of 974 km encompassing 9 coastal districts has had a long history of fishing. Starting with traditional fishing in ancient times to the modern, technology-intensive fishing, the marine fisheries sector of the state has grown tremendously reaching record landings of 3.42 lakh tonnes in 2014. The state has 555 marine fishing villages with 353 marine fish landing centres (CMFRI Marine Fisheriers Census, 2010). There are two major fishing harbors at Visakhapatnam and Kakinada where bulk of total trawl catch (nearly 70%) is landed and three minor fishing harbors at Bhairavapalem, Machilipatnam and Nizamapatnam. The marine fishermen population of the state is more than 6 lakhs with roughly a quarter of them, being acive in fishery related activities throughout the year. There are 31,741 fishing crafts in the marine fisheries of Andhra pradesh (CMFRI Marine Fisheriers Census, 2010). The marine fisheries sector, at present, is an important source of employment and income generation in the state, but is plagued with several problems. As because, this sector is vulnerable to external influences viz., overexploitation of marine resources, environmental degradation and climate change, efficient management is the need of the hour

महाराष्‍ट्, गुजरात और आंध्रा प्रदेश तटों के चुने गए स्थानों पर समुद्री शैवाल कॉलेर्पा प्रजाति का पैदावार

कॉलर्पा अंतराज्वारीय समुद्री क्षेत्ररों मेें प्रचुर मात्रा मेें पायी जाने वाली समुद्री शैवाल प्रजातियोों मेें एक है। मालवन और कोलाबा (महाराष्‍ट्र), वेरावल और ओखा (गुजरात) के तटोों से निम्‍न ज्वार के दौरान संग्रहित नमूनोों की विविधता और मौसमिकता पर अध्‍ययन किया गया और विशाखपट्टणम (आंध्रा प्रदेश) मेें किए गए समान अध्‍ययन के साथ तुलना भी की गयी। महाराष्‍ट्र और गुजरात के क्षेत्ररों से किए गए नमूना प्रतिचयन से कॉलर्पा वंश के ग्यारह टैक्सी की दर्ज की गयी, जिनमेें से आठ प्रजातियााँ और तीन किस्‍म मौजूद थे, बल्कि चार प्रजातियााँ विशाखपट्टणम क्षेत्र से प्राप्‍त की गयीीं

Trawl Fisheries in Andhra Pradesh: Facts and fishers insight

Along Andhra Pradesh coast, only indigenous gear operating country crafts were in vogue till the turn of 1960 and since 1964, with the advent of the Indo-Norwegian project, fishing by small mechanized fishing crafts started. Initially, Pablo type (9.14 m length; 2.14 m beam; and 40-45 HP engine) were present and within three years, two other types, namely “Royya” (9.75 -10.0 m length; 2.9 m beam; and 45-60 HP engine) and “Sorrah” (11.4 m length; 3.2 m beam; and 60-80 HP engine) with modifications in structure and engine capacity were introduced

Marine Fisheries Policy Series-9; Policy Guidance on sustaining the Marine Fisheries of Andhra Pradesh

Policy Guidance on sustaining the Marine Fisheries of Andhra Prades

Status of Large Pelagics fishery in Andhra Pradesh

Large pelagics forms an important fishery along Andhra Pradesh coast, 26 species of large pelagics are caught in the state. This group accounts to an annual average of 9% of total states marine catches (2.5 lakh ton) since a decade and highest contribution of large pelagics to the total states landing was recorded in 2014 (12%). Tunas dominated the large pelagics landings, followed by seerfishes and barracuda. Gillnets are mainly employed to catch tunas, seer fishes, billfishes and queenfishes, trawls for barracudas and hook and line for Dolphinfish. Peak landing occurred during the December - March period. Among the large pelagics, seerfishes fetched the highest price in the market

Visakhapatnam Regional Centre: A Profile

The Visakhapatnam Regional Centre of ICAR - CMFRI had its beginning in 1947 as a Survey Unit, which was housed in the premises of the Department of Fisheries, Government of Andhra Pradesh. The main function of the Survey Unit was to collect the fish landing data. The Survey Unit was upgraded as a Research Unit and research activities were initiated in the year 1955 in the premises of Department of Zoology, Andhra University. Later, the Calcutta Research Unit of CMFRI was merged with the Visakhapatnam Research Unit of CMFRI in 1962. During 1970, the Research Unit housed within the premises of Department of Zoology, Andhra University was elevated to a Sub-station and subsequently as a Research Centre in 1976. The Research Centre moved into its own building in 1995, and was further upgraded as the Regional Centre on 17th October, 2001. The Kakinada Research Centre of CMFRI was merged with the Visakhapatnam Regional Centre of CMFRI on 15th February, 200

Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets

BACKGROUND: Targeting persistent tubercule bacilli has become an important challenge in the development of anti-tuberculous drugs. As the glyoxylate bypass is essential for persistent bacilli, interference with it holds the potential for designing new antibacterial drugs. We have developed kinetic models of the tricarboxylic acid cycle and glyoxylate bypass in Escherichia coli and Mycobacterium tuberculosis, and studied the effects of inhibition of various enzymes in the M. tuberculosis model. RESULTS: We used E. coli to validate the pathway-modeling protocol and showed that changes in metabolic flux can be estimated from gene expression data. The M. tuberculosis model reproduced the observation that deletion of one of the two isocitrate lyase genes has little effect on bacterial growth in macrophages, but deletion of both genes leads to the elimination of the bacilli from the lungs. It also substantiated the inhibition of isocitrate lyases by 3-nitropropionate. On the basis of our simulation studies, we propose that: (i) fractional inactivation of both isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 is required for a flux through the glyoxylate bypass in persistent mycobacteria; and (ii) increasing the amount of active isocitrate dehydrogenases can stop the flux through the glyoxylate bypass, so the kinase that inactivates isocitrate dehydrogenase 1 and/or the proposed inactivator of isocitrate dehydrogenase 2 is a potential target for drugs against persistent mycobacteria. In addition, competitive inhibition of isocitrate lyases along with a reduction in the inactivation of isocitrate dehydrogenases appears to be a feasible strategy for targeting persistent mycobacteria. CONCLUSION: We used kinetic modeling of biochemical pathways to assess various potential anti-tuberculous drug targets that interfere with the glyoxylate bypass flux, and indicated the type of inhibition needed to eliminate the pathogen. The advantage of such an approach to the assessment of drug targets is that it facilitates the study of systemic effect(s) of the modulation of the target enzyme(s) in the cellular environment

Collaborative development of predictive toxicology applications

OpenTox provides an interoperable, standards-based Framework for the support of predictive toxicology data management, algorithms, modelling, validation and reporting. It is relevant to satisfying the chemical safety assessment requirements of the REACH legislation as it supports access to experimental data, (Quantitative) Structure-Activity Relationship models, and toxicological information through an integrating platform that adheres to regulatory requirements and OECD validation principles. Initial research defined the essential components of the Framework including the approach to data access, schema and management, use of controlled vocabularies and ontologies, architecture, web service and communications protocols, and selection and integration of algorithms for predictive modelling. OpenTox provides end-user oriented tools to non-computational specialists, risk assessors, and toxicological experts in addition to Application Programming Interfaces (APIs) for developers of new applications. OpenTox actively supports public standards for data representation, interfaces, vocabularies and ontologies, Open Source approaches to core platform components, and community-based collaboration approaches, so as to progress system interoperability goals