Superfluid state of repulsively interacting three-component fermionic atoms in optical lattices

We investigate the superfluid state of repulsively interacting three-component (color) fermionic atoms in optical lattices. When the anisotropy of the three repulsive interactions is strong, atoms of two of the three colors form Cooper pairs and atoms of the third color remain a Fermi liquid. An effective attractive interaction is induced by density fluctuations of the third-color atoms. This superfluid state is stable against changes in filling close to half filling. We determine the phase diagrams in terms of temperature, filling, and the anisotropy of the repulsive interactions.Comment: 5 pages, 6 figure

Activation volumes in CoPtCr-SiO2 perpendicular recording media

CoPtCr-SiO2 perpendicular recording media with varying levels of SiO2 were examined by two different methods to determine the activation volume. The first is based on the sweep-rate dependence of the remanence coercivity using Sharrock's equation. The second is based on the measurement of the fluctuation field from time-dependence data, determined using a magneto-optical Kerr effect (MOKE) magnetometer. The values of V-act measured at the coercivity for both methods are almost the same, with the fluctuation field and activation volumes increasing with the SiO2 content. The difference between V-act and the grain volume measured directly from bright-field TEM images decreases as the SiO2 content increases due to the reduction of intergranular exchange coupling. The experimental results indicate that values of V-act obtained from single- and double-layered media are consistent. It was also found that the coercivity and normalized hysteresis loop slope at coercivity varied with SiO2 content, with the coercivity peaking at 8 at % SiO2 (nearly 26 vol% SiO2)

Shock propagation through a bubbly liquid in a deformable tube

Shock propagation through a bubbly liquid contained in a deformable tube is considered. Quasi-one-dimensional mixture-averaged flow equations that include fluid–structure interaction are formulated. The steady shock relations are derived and the nonlinear effect due to the gas-phase compressibility is examined. Experiments are conducted in which a free-falling steel projectile impacts the top of an air/water mixture in a polycarbonate tube, and stress waves in the tube material and pressure on the tube wall are measured. The experimental data indicate that the linear theory is incapable of properly predicting the propagation speeds of finite-amplitude waves in a mixture-filled tube; the shock theory is found to more accurately estimate the measured wave speeds

Current-feedback-stabilized laser system for quantum simulation experiments using Yb clock transition at 578 nm

We developed a laser system for the spectroscopy of the clock transition in ytterbium (Yb) atoms at 578 nm based on an interference-filter stabilized external-cavity diode laser (IFDL) emitting at 1156 nm. Owing to the improved frequency-to-current response of the laser-diode chip and the less sensitivity of the IFDL to mechanical perturbations, we succeeded in stabilizing the frequency to a high-finesse ultra-low-expansion glass cavity with a simple current feedback system. Using this laser system, we performed high-resolution clock spectroscopy of Yb and found that the linewidth of the stabilized laser was less than 320 Hz.Comment: 5 pages, 7 figure

Shock Theory of a Bubbly Liquid in a Deformable Tube

Shock propagation through a bubbly liquid filled in a deformable cylindrical tube is considered. Quasi-one-dimensional bubbly flow equations that include fluid-structure interaction are formulated, and the steady shock relations are derived. Experiments are conducted in which a free-falling steel projectile impacts the top of an air/water mixture in a polycarbonate tube, and stress waves in the tube material are measured. The experimental data indicate that the linear theory cannot properly predict the propagation speeds of shock waves in mixture-filled tubes; the shock theory is found to more accurately estimate the measured wave speeds

Supersolid state in fermionic optical lattice systems

We study ultracold fermionic atoms trapped in an optical lattice with harmonic confinement by combining the real-space dynamical mean-field theory with a two-site impurity solver. By calculating the local particle density and the pair potential in the systems with different clusters, we discuss the stability of a supersolid state, where an s-wave superfluid coexists with a density-wave state of checkerboard pattern. It is clarified that a confining potential plays an essential role in stabilizing the supersolid state. The phase diagrams are obtained for several effective particle densities.Comment: 7 pages, 5 figures, Phys. Rev. A in pres

Electronic Structure of Charge- and Spin-controlled Sr_{1-(x+y)}La_{x+y}Ti_{1-x}Cr_{x}O_{3}

We present the electronic structure of Sr_{1-(x+y)}La_{x+y}Ti_{1-x}Cr_{x}O_{3} investigated by high-resolution photoemission spectroscopy. In the vicinity of Fermi level, it was found that the electronic structure were composed of a Cr 3d local state with the t_{2g}^{3} configuration and a Ti 3d itinerant state. The energy levels of these Cr and Ti 3d states are well interpreted by the difference of the charge-transfer energy of both ions. The spectral weight of the Cr 3d state is completely proportional to the spin concentration x irrespective of the carrier concentration y, indicating that the spin density can be controlled by x as desired. In contrast, the spectral weight of the Ti 3d state is not proportional to y, depending on the amount of Cr doping.Comment: 4 pages, 3 figures. Accepted for publication in Phys. Rev. Let

The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli

During their final differentiation or maturation, dendritic cells (DCs) redistribute their major histocompatibility complex (MHC) class II products from intracellular compartments to the plasma membrane. Using cells arrested in the immature state, we now find that DCs also regulate the initial intracellular formation of immunogenic MHC class II-peptide complexes. Immature DCs internalize the protein antigen, hen egg lysozyme (HEL), into late endosomes and lysosomes rich in MHC class II molecules. There, despite extensive colocalization of HEL protein and MHC class II products, MHC class II-peptide complexes do not form unless the DCs are exposed to inflammatory mediators such as tumor necrosis factor α, CD40 ligand, or lipoplolysaccharide. The control of T cell receptor (TCR) ligand formation was observed using the C4H3 monoclonal antibody to detect MHC class II-HEL peptide complexes by flow cytometry and confocal microscopy, and with HEL-specific 3A9 transgenic T cells to detect downregulation of the TCR upon MHC-peptide encounter. Even the binding of preprocessed HEL peptide to MHC class II is blocked in immature DCs, including the formation of C4H3 epitope in MHC class II compartments, suggesting an arrest to antigen presentation at the peptide-loading step, rather than an enhanced degradation of MHC class II-peptide complexes at the cell surface, as described in previous work. Therefore, the capacity of late endosomes and lysosomes to produce MHC class II-peptide complexes can be strictly controlled during DC differentiation, helping to coordinate antigen acquisition and inflammatory stimuli with formation of TCR ligands. The increased ability of maturing DCs to load MHC class II molecules with antigenic cargo contributes to the \u3e100-fold enhancement of the subsequent primary immune response observed when immature and mature DCs are compared as immune adjuvants in culture and in mice

Thyrotropin Receptor Epitope and Human Leukocyte Antigen in Graves’ Disease

Graves’ disease (GD) is an organ-specific autoimmune disease, and thyrotropin (TSH) receptor (TSHR) is a major autoantigen in this condition. Since the extracellular domain of human TSHR (TSHR-ECD) is shed into the circulation, TSHR-ECD is a preferentially immunogenic portion of TSHR. Both genetic factors and environmental factors contribute to development of GD. Inheritance of human leukocyte antigen (HLA) genes, especially HLA-DR3, is associated with GD. TSHR-ECD protein is endocytosed into antigen-presenting cells (APCs), and processed to TSHR-ECD peptides. These peptide epitopes bind to HLA-class II molecules, and subsequently the complex of HLA-class II and TSHR-ECD epitope is presented to CD4+ T cells. The activated CD4+ T cells secrete cytokines/chemokines that stimulate B-cells to produce TSAb, and in turn hyperthyroidism occurs. Numerous studies have been done to identify T- and B-cell epitopes in TSHR-ECD, including (1) in silico, (2) in vitro, (3) in vivo, and (4) clinical experiments. Murine models of GD and HLA-transgenic mice have played a pivotal role in elucidating the immunological mechanisms. To date, linear or conformational epitopes of TSHR-ECD, as well as the molecular structure of the epitope-binding groove in HLA-DR, were reported to be related to the pathogenesis in GD. Dysfunction of central tolerance in the thymus, or in peripheral tolerance, such as regulatory T cells, could allow development of GD. Novel treatments using TSHR antagonists or mutated TSHR peptides have been reported to be effective. We review and update the role of immunogenic TSHR epitopes and HLA in GD, and offer perspectives on TSHR epitope specific treatments