Spatial clustering of array CGH features in combination with hierarchical multiple testing

We propose a new approach for clustering DNA features using array CGH data from multiple tumor samples. We distinguish data-collapsing: joining contiguous DNA clones or probes with extremely similar data into regions, from clustering: joining contiguous, correlated regions based on a maximum likelihood principle. The model-based clustering algorithm accounts for the apparent spatial patterns in the data. We evaluate the randomness of the clustering result by a cluster stability score in combination with cross-validation. Moreover, we argue that the clustering really captures spatial genomic dependency by showing that coincidental clustering of independent regions is very unlikely. Using the region and cluster information, we combine testing of these for association with a clinical variable in an hierarchical multiple testing approach. This allows for interpreting the significance of both regions and clusters while controlling the Family-Wise Error Rate simultaneously. We prove that in the context of permutation tests and permutation-invariant clusters it is allowed to perform clustering and testing on the same data set. Our procedures are illustrated on two cancer data sets

Letter from Geraldine Ferraro to the Red Cross of San Juan de Dios in Costa Rica

Letter from Geraldine Ferraro to the Red Cross of San Juan de Dios in Costa Rica. Letter has handwritten notes.https://ir.lawnet.fordham.edu/vice_presidential_campaign_correspondence_1984_international/1342/thumbnail.jp

Is There Really a de Sitter/CFT Duality

In this paper a de Sitter Space version of Black Hole Complementarity is formulated which states that an observer in de Sitter Space describes the surrounding space as a sealed finite temperature cavity bounded by a horizon which allows no loss of information. We then discuss the implications of this for the existence of boundary correlators in the hypothesized dS/cft correspondence. We find that dS complementarity precludes the existence of the appropriate limits. We find that the limits exist only in approximations in which the entropy of the de Sitter Space is infinite. The reason that the correlators exist in quantum field theory in the de Sitter Space background is traced to the fact that horizon entropy is infinite in QFT.Comment: 12 Figures, STIAS Workshop on Quantum Gravit

SAXJ1712.6-3739: a persistent hard X-ray source as monitored with INTEGRAL

The X-ray source SAXJ1712.6-3739 is a very weak Low Mass X-ray Binary discovered in 1999 with BeppoSAX and located in the Galactic Center. This region has been deeply investigated by the INTEGRAL satellite with an unprecedented exposure time, giving us an unique opportunity to study the hard X-ray behavior also for weak objects. The spectral results are based on the systematic analysis of all INTEGRAL observations covering the source position performed between February 2003 and October 2006. SAXJ1712.6-3739 did not shows any flux variation along this period as well as compared to previous BeppoSAX observation. Hence, to better constrain the physical parameters we combined both instrument data. Long INTEGRAL monitoring reveals, for the first time, that this X-ray burster is a weak persistent source, displaying a X-ray spectrum extended to high energy and spending most of the time in a low luminosity hard state. The broad-band spectrum is well modeled with a simple Comptonized model with a seed photons temperature of ~0.5keV and an electron temperature of ~24keV. The low mass accretion rate (~2x10^{-10} Msun/yr), the long bursts recurrence time, the small sizes of the region emitting the seed photons consisting with the inner disk radius and the high luminosity ratio in the 40-100keV and 20-40keV band, are all features common to the Ultra Compact source class.Comment: accepted A&

Melt block copolymerization of ε-caprolactone and L-lactide

AB block copolymers of ε-caprolactone and (L)-lactide could be prepared by ring-opening polymerization in the melt at 110°C using stannous octoate as a catalyst and ethanol as an initiator provided ε-caprolactone was polymerized first. Ethanol initiated the polymerization of ε-caprolactone producing a polymer with ε-caprolactone derived hydroxyl end groups which after addition of L-lactide in the second step of the polymerization initiated the ring-opening copolymerization of L-lactide. The number-average molecular weights of the poly(ε-caprolactone) blocks varied from 1.5 to 5.2 × 103, while those of the poly(L-lactide) blocks ranged from 17.4 to 49.7 × 103. The polydispersities of the block copolymers varied from 1.16 to 1.27. The number-average molecular weights of the polymers were controlled by the monomer/hydroxyl group ratio, and were independent on the monomer/stannous octoate ratio within the range of experimental conditions studied. When L-lactide was polymerized first, followed by copolymerization of ε-caprolactone, random copolymers were obtained. The formation of random copolymers was attributed to the occurrence of transesterification reactions. These side reactions were caused by the ε-caprolactone derived hydroxyl end groups generated during the copolymerization of ε-caprolactone with pre-polymers of L-lactide. The polymerization proceeds through an ester alcoholysis reaction mechanism, in which the stannous octoate activated ester groups of the monomers react with hydroxyl groups

Microscopy study of ripples created on steel surface by use of ultra short laser pulses

This paper concentrates on ripples on the surface of steel that arise from lasermaterial interaction. In particular we have observed two different sets of ripples on steel samples that were machined by 210 fs laser pulses with 800 nm wavelength at normal incidence. Small ripples were found with spacing of about 250 nm lying longitudinal to the vector of laser beam polarization. Big ripples exhibited at a much larger distance of about 500 nm and they are perpendicular to the polarization vector. The laser treated surfaces were investigated with\ud Scanning Electron, Confocal and Atomic Force Microscopy. The laser-material interaction could be divided into three subsequent steps: absorption of laser light via electron gas excitations, transfer of heat into the lattice followed by a thermal expansion of material. From our microscopic observations it is concluded that the small ripples are formed by solidification of liquid material present as a thin layer near the interface of solid bulk material

'Ticking the Ethnic Box' : The experiences of minority ethnic young people in rural communities

Peer reviewedPublisher PD