378 research outputs found

    Catalytic Asymmetric Hydrogenation in the Manufacture of d-Biotin and Dextromethorphan

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    Two enantiomerically pure products, (+)-biotin and dextromethorphan, have been chosen to illustrate the acquisition, development, and implementation of the catalytic asymmetric hydrogenation technology at Lonza Fine Chemicals. Taking advantage of the recently developed Ciba-Geigy ferrocenyl-type phosphine ligands, processes for the stereoselective hydrogenation of a C=C- and a C=N bond, respectively, have been developed and successfully scaled up

    Some Comments about Mr. David Karp\u27s Remarks on Propensity Evidence

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    The Case Against Abandoning the Search for Substantive Accuracy

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