Antibiotic Susceptibility Profile of Pseudomonas aeruginosa Canine Isolates from a Multicentric Study in Romania

Treating infections caused by Pseudomonas aeruginosa is increasingly difficult due to high antibiotic resistance, materialized through the presence of multiple resistance strains, as well as due to rapid development of resistance throughout treatment. The present survey was conducted to investigate the antibiotic susceptibility profile of Pseudomonas aeruginosa pathogens in two University Veterinary hospitals from different geographical regions of Romania (i.e., Southwest Timișoara county and Northeast Iași county) involved in superficial canine infections. A total of 142 swab specimens were collected from dogs with superficial infections (superficial skin infections, otitis externa, and perianal abscess) to assess the presence of Pseudomonas aeruginosa, based on phenotypic and molecular characterization. According to their confirmed morphological and molecular features, 58 samples (40.84%; 58/142) were positive for Pseudomonas aeruginosa (according to their confirmed morphological and molecular features). Antibiotic susceptibility testing for 12 antibiotics was conducted using the Kirby–Bauer disc diffusion method. Drug resistance was observed in the case of all tested antibiotics. The susceptibility rate of P. aeruginosa strains that were tested in this study was in the following order: ceftazidime (53.44%; 31/58), followed by aztreonam (51.72%; 30/58), amikacin (44.82%; 26/58), azithromycin (41.37%; 24/58), gentamicin (37.93%; 22/58), cefepime (36.20%; 21/58), meropenem (25.86%; 13/58), piperacillin-tazobactam (25.86%; 13/58), imipenem (22.41%; 13/158), ciprofloxacin (17.24%; 10/58), tobramycin (8.62; 5/58), and polymyxin B (1.72; 1/58). The results highlight the importance of antibiotic susceptibility testing in Pseudomonas aeruginosa isolates from dogs with superficial infections to use an adequate treatment plan to manage the skin condition and other pathologies (otitis externa and perianal abscesses)

Composition and Efficacy of a Natural Phytotherapeutic Blend against Nosemosis in Honey Bees

Honey bees are essential to sustaining ecosystems, contributing to the stability of biodiversity through pollination. Today, it is known that the failure of pollination leads irremediably to the loss of plant cultures and, as a consequence, inducing food security issues. Bees can be affected by various factors, one of these being Nosema spp. which are protozoans specifically affecting adult honey bees and a threat to bee populations around the world. The composition of the phytotherapeutic product (Protofil®) for treating nosemosis was analyzed from a biochemical point of view. The most concentrated soluble parts in the phytotherapeutic association were the flavonoids, most frequently rutin, but quercetin was also detected. Additionally, the main volatile compounds identified were eucalyptol (1.8-cineol) and chavicol-methyl-ether. To evaluate the samples’ similarity–dissimilarity, the PCA multivariate statistical analysis, of the gas-chromatographic data (centered relative percentages of the volatile compounds), was applied. Statistical analysis revealed a significant similarity of Protofil® with the Achillea millefolium (Yarrow) samples and more limited with Thymus vulgaris (Thyme) and Ocimum basilicum (Basil), and, respectively, a meaningful dissimilarity with Taraxacum officinale (Dandelion). The results have shown a high and beneficial active compounds concentration in the analyzed herbs. High similarity with investigated product recommending the Protofil®, as the treatment compatible with producing organic honey

Review of Cryptosporidium and Giardia in the eastern part of Europe, 2016

Introduction: This paper reviews the current knowledge and understanding of Cryptosporidium spp. an d Giardia spp. in humans, animals and the environment in 10 countries in the eastern part of Europe: Bosnia and Herzegovina, Croatia, Czech Republic, Estonia, Hungary, Latvia, Poland, Romania, Serbia and Slovenia. Methods: Published scientific papers and conference proceedings from the international and local literature, official national health service reports, national databases and doctoral theses in local languages were reviewed to provide an extensive overview on the epidemiology, diagnostics and research on these pathogens, as well as analyse knowledge gaps and areas for further research. Results: Cryptosporidium spp. and Giardia spp. were found to be common in eastern Europe, but the results from different countries are difficult to compare because of variations in reporting practices and detection methodologies used. Conclusion: Upgrading and making the diagnosis/detection procedures more uniform is recommended throughout the region. Public health authorities should actively work towards increasing reporting and standardising reporting practices as these prerequisites for the reported data to be valid and therefore necessary for appropriate control plans.Peer reviewe

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Buike/Kalman - come Zigany - deep violin - audio

Buike arrangement of "Imre Kalman, Countess Maritza" 1st mov. no.7 final, "Come Zigany" German incipit: "Auch ich war einst ein feiner Csardas-Kavalier" - for deep violin, piano, reed, harmonium, accordion ad lib. BBWV 137 - 6:06 (developed from printed piano-reduction Vienna 1924 (in IMSLP) - see from this project: BBWV 139 arrangement for high violin, strings - see essay E23 (double no.) Music -Military - Mokasha, 58 p., 2019 - see essay: Hungarian Gipsy Music and Indian Raga, 124 p. - 202

Buike/Kalman - come Zigany - high violin - sheetmusic

Buike arrangement high violin, strings BBWV 139 - 6:06 - sheetmusic performance pack 55 p. - on Imre Kalman "Come Zigany" from "Countess Maritza", 1st mov. no.7, final - German incipit "Auch ich war einst ein feiner Cszardaskavalier" - derived from piano reduction Vienna 1924 in IMSLP and from listening to Andre Rieu in youtube -see from this project BBWV 137 arr. for deep violin, piano - see essay E23 (double no.) Music - Military - Moksha, 58 p., 2019 - see essay "Hungarian Gipsy Music and Indian Raga", 124 p. 202

Imre Kalman - Come Zigan - piano, deep violin - audio

BB 137 - Come Zigany / Komm Zigan - Canzona e Csardas - set to Gipsy violin from Imre Kalman, Countess Mariza, 1 st mov. No.7 - 137.1 piano (Harmonium, reed), deep violin 137.2 deep violin - audio - compare with BB 137 reed/Harmonium audio, which was derived from my studies on INDIAN rests in Hungarian Gipsy msuic and is rather convincin

Buike/Kalman - come Zigany - high violin - audio

Buike arrangement for high violin, strings - BBWV 139 - 6:06 - on Imre Kalman "Come Zigany" from "Countess Maritza", 1st. mov. final no.7, German incipit "Auch ich war einst ein feiner Cszardaskavalier" - derived from piano reduction, Vienna 1924 in IMSLP and from listening to Andre Rieu in youtube - see from this project BBWV 137 arranged for deep violin, piano - see essay E 23(double no.) Music - Miliary - Moksha, 58 p. 2019 - see essay "Hungarin Gipsy Music and Indian Raga", 124 p., 202