Potential of replacing pawpaw fruit and leaves with cabbage peels as a natural feedstuff in the diet of Achatina achatina linne (African giant land snail)

An experiment was carried out to assess the growth performance of African Giant Land Snail Achatina achatina Linnie fed with three natural feedstuff; pawpaw fruit, pawpaw leaves and cabbage leaves. A total of 24 growing snails of approximately one year old were used for the study. These were randomly divided into six groups and then allotted into the three experimental diets, arranged in a completely randomised design (CRD) order. Dry matter intakes of feed being served every other days, weight gain and size increase of snails were assessed fortnightly. The results showed that pawpaw leaf is higher in protein than cabbage leaf and pawpaw fruit. However, cabbage leaf contains some essential mineralelements, which are useful in body building than the other two feedstuffs. It also showed that snails fed with cabbage leaves had the highest dry matter intake and weight gain of 14.2 and 18.6 g, respectively.Highest shell length and circumference increase of 0.3 and 0.6 cm were obtained in pawpaw fruit and pawpaw leaf respectively. Although there was no significance difference (p > 0.05) in the weight gain ofsnails fed with pawpaw fruit and cabbage leaves, cabbage leaf seems to be richer in protein and other essential mineral elements than pawpaw fruit. It was therefore concluded that cabbage leaf could serve as a good substitute for pawpaw fruit and leaves, which hitherto were known as the preferred natural feedstuff of snails

Bistability and Bacterial Infections

Bacterial infections occur when the natural host defenses are overwhelmed by invading bacteria. The main component of the host defense is impaired when neutrophil count or function is too low, putting the host at great risk of developing an acute infection. In people with intact immune systems, neutrophil count increases during bacterial infection. However, there are two important clinical cases in which they remain constant: a) in patients with neutropenic-associated conditions, such as those undergoing chemotherapy at the nadir (the minimum clinically observable neutrophil level); b) in ex vivo examination of the patient's neutrophil bactericidal activity. Here we study bacterial population dynamics under fixed neutrophil levels by mathematical modelling. We show that under reasonable biological assumptions, there are only two possible scenarios: 1) Bacterial behavior is monostable: it always converges to a stable equilibrium of bacterial concentration which only depends, in a gradual manner, on the neutrophil level (and not on the initial bacterial level). We call such a behavior type I dynamics. 2) The bacterial dynamics is bistable for some range of neutrophil levels. We call such a behavior type II dynamics. In the bistable case (type II), one equilibrium corresponds to a healthy state whereas the other corresponds to a fulminant bacterial infection. We demonstrate that published data of in vitro Staphylococcus epidermidis bactericidal experiments are inconsistent with both the type I dynamics and the commonly used linear model and are consistent with type II dynamics. We argue that type II dynamics is a plausible mechanism for the development of a fulminant infection

Estimation of Ligament Loading and Anterior Tibial Translation in Healthy and ACL-Deficient Knees During Gait and the Influence of Increasing Tibial Slope Using EMG-Driven Approach

The purpose of this study was to develop a biomechanical model to estimate anterior tibial translation (ATT), anterior shear forces, and ligament loading in the healthy and anterior cruciate ligament (ACL)-deficient knee joint during gait. This model used electromyography (EMG), joint position, and force plate data as inputs to calculate ligament loading during stance phase. First, an EMG-driven model was used to calculate forces for the major muscles crossing the knee joint. The calculated muscle forces were used as inputs to a knee model that incorporated a knee–ligament model in order to solve for ATT and ligament forces. The model took advantage of using EMGs as inputs, and could account for the abnormal muscle activation patterns of ACL-deficient gait. We validated our model by comparing the calculated results with previous in vitro, in vivo, and numerical studies of healthy and ACL-deficient knees, and this gave us confidence on the accuracy of our model calculations. Our model predicted that ATT increased throughout stance phase for the ACL-deficient knee compared with the healthy knee. The medial collateral ligament functioned as the main passive restraint to anterior shear force in the ACL-deficient knee. Although strong co-contraction of knee flexors was found to help restrain ATT in the ACL-deficient knee, it did not counteract the effect of ACL rupture. Posterior inclination angle of the tibial plateau was found to be a crucial parameter in determining knee mechanics, and increasing the tibial slope inclination in our model would increase the resulting ATT and ligament forces in both healthy and ACL-deficient knees

Preliminary Studies On Performance Of Cane Rat (Thryonomys swinderianus) At The Forestry Research Institute Of Nigeria (FRIN)

The study focused on the performance and reproductive traits of grasscutter being domesticated at the Forestry Research Institute of Nigeria (FRIN). Data was collected for a period of three years (2003-2006).Results revealed that elephant grass, which is the choice, feed for grasscutter is of low nutritional value, hence necessitating the use of formulated concentrates as supplement. Performance results showed that the mature bucks (male grasscutters) gained more weight than the does(female grasscutters) and also consumed more feed. The buck consumed 175.50+5.00g of concentrate per day while the doe consumed 150.80+7.50 per day. The average forage intake was 608.33+18.33g and504.00+5.10g for the mature bucks and does respectively. The result also showed that the average weight gain (g/animal/day) was greater in the buck (4.26+0.81g) while that of the female was (2.67+0.61g). Thefeed conversion ratio for the buck was 0.08+0.001 and 0.02+0.003 for the forage and concentrates respectively, while that of the doe was 0.005+0.0008 and 0.018+0.0007 for forage and concentratesrespectively. The cost of concentrate in Naira per kilogram is N 22 and the cost/ unit weight gain is N 0.90 and N 1.24 for the bulk and doe respectively. The doe had a gestation period of (151+3 days) and a littersize of (3.90+0.7). The litter ratio showed that the doe gave birth to more males than females and the male is heavier at birth than the female

Session 1668

This paper presents an overview of an interactive multimedia vibrations program called GT Vibrations. GT Vibrations contains a series of modules that deal with elementary vibrations, transient vibrations, and continuous systems. The program is intended to be used as a supplemental tool for undergraduate courses in vibrations and system dynamics at Georgia Tech. The underlying goal of the program is to enhance the student's knowledge of vibrations by supplementing complex problems with text, graphics, animation, sound, and interaction. The program presents the student with what-if design scenarios in which he can modify different parameters of a mechanical system; in this fashion the student can see how different parameters affect the overall response of a system. The program is essentially a visual design tool which complements the theory and problem solving done in the classroom. Introduction GT Vibrations is an interactive multimedia program designed to be used as a supplemental to..

3p Arm Loss and Survival in Head and Neck Cancer: An Analysis of TCGA Dataset

Loss of the 3p chromosome arm has previously been reported to be a biomarker of poorer outcome in both human papillomavirus (HPV)-positive and HPV-negative head and neck cancer. However, the precise operational measurement of 3p arm loss is unclear and the mutational profile associated with the event has not been thoroughly characterized. We downloaded the clinical, single nucleotide variation (SNV), copy number aberration (CNA), RNA sequencing, and reverse phase protein assay (RPPA) data from The Cancer Genome Atlas (TCGA) and The Cancer Proteome Atlas HNSCC cohorts. Survival data and hypoxia scores were downloaded from published studies. In addition, we report the inclusion of an independent Memorial Sloan Kettering cohort. We assessed the frequency of loci deletions across the 3p arm separately in HPV-positive and -negative disease. We found that deletions on chromosome 3p were almost exclusively an all or none event in the HPV-negative cohort; patients either had <1% or >97% of the arm deleted. 3p arm loss, defined as >97% deletion in HPV-positive patients and >50% in HPV-negative patients, had no impact on survival (p > 0.05). However, HPV-negative tumors with 3p arm loss presented at a higher N-category and overall stage and developed more distant metastases (p < 0.05). They were enriched for SNVs in TP53, and depleted for point mutations in CASP8, HRAS, HLA-A, HUWE1, HLA-B, and COL22A1 (false discovery rate, FDR < 0.05). 3p arm loss was associated with CNAs across the whole genome (FDR < 0.1), and pathway analysis revealed low lymphoid-non-lymphoid cell interactions and cytokine signaling (FDR < 0.1). In the tumor microenvironment, 3p arm lost tumors had low immune cell infiltration (FDR < 0.1) and elevated hypoxia (FDR < 0.1). 3p arm lost tumors had lower abundance of proteins phospho-HER3 and ANXA1, and higher abundance of miRNAs hsa-miR-548k and hsa-miR-421, which were all associated with survival. There were no molecular differences by 3p arm status in HPV-positive patients, at least at our statistical power level. 3p arm loss is largely an all or none phenomenon in HPV-negative disease and does not predict poorer survival from the time of diagnosis in TCGA cohort. However, it produces tumors with distinct molecular characteristics and may represent a clinically useful biomarker to guide treatment decisions for HPV-negative patients