Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency.

Mitochondrial diseases due to a reduced capacity for oxidative phosphorylation were first identified more than 20 years ago, and their incidence is now recognized to be quite significant. In a large proportion of cases the problem can be traced to a complex I (NADH-CoQ oxidoreductase) deficiency (Phenotype MIM #252010). Because the complex consists of 44 subunits, there are many potential targets for pathogenic mutations, both on the nuclear and mitochondrial genomes. Surprisingly, however, almost half of the complex I deficiencies are due to defects in as yet unidentified genes that encode proteins other than the structural proteins of the complex. This review attempts to summarize what we know about the molecular basis of complex I deficiencies: mutations in the known structural genes, and mutations in an increasing number of genes encoding "assembly factors", that is, proteins required for the biogenesis of a functional complex I that are not found in the final complex I. More such genes must be identified before definitive genetic counselling can be applied in all cases of affected families

Inclination effects in T Tauri star spectra

CONTEXT. Because of the presence of rotation and accretion disks, classical T Tauri stars have symmetry planes that are normally inclined relative to the plane of the sky. The inclination angles affect the observed spectral properties of these objects. AIMS. We study the influence of the inclination angles on classical T Tauri star spectra in an empirical manner. METHODS. Published inclination angles, derived from the stellar photospheric rotation or from spatially resolved circumstellar disk observations, are compared with various observed spectral properties, and correlations are established and investigated. RESULTS. Inclinations derived from the stellar rotation are found to be much less accurate than the published disk inclinations, and no significant correlations between spectral properties and inclinations based on rotation data could be detected. In contrast, significant correlations are found between the disk inclination angles and the apparent velocities observed for the forbidden emission lines and the wind absorption features of permitted lines. These data support the assumption of cone-like polar winds with opening angles smaller than $\approx 45^\circ$. Other spectral features show weaker or no inclination dependence. Using these results, the true (deprojected) flow velocities of the polar winds are derived for the investigated sample of T Tauri stars. Deprojected wind-ejection velocities appear to differ by a factor of two among the stars in our sample, which spans a range of mass-loss rates from $10^{-10}$M$_\odot$/yr to $3 \times 10^{-7}$M$_\odot$/yr.Comment: accepted by Astronomy and Astrophysic

Database Optimizing Services

Almost every organization has at its centre a database. The database provides support for conducting different activities, whether it is production, sales and marketing or internal operations. Every day, a database is accessed for help in strategic decisions. The satisfaction therefore of such needs is entailed with a high quality security and availability. Those needs can be realised using a DBMS (Database Management System) which is, in fact, software for a database. Technically speaking, it is software which uses a standard method of cataloguing, recovery, and running different data queries. DBMS manages the input data, organizes it, and provides ways of modifying or extracting the data by its users or other programs. Managing the database is an operation that requires periodical updates, optimizing and monitoring.database, database management system (DBMS), indexing, optimizing, cost for optimized databases

Biologisch-dynamische Forschung

Biologisch-dynamische Forschung bezieht naturwissenschaftliche und geisteswissenschaftliche Aspekte in die Arbeit ein und nimmt daher Wissenschaftlichkeit in einem erweiterten Sinn für sich in Anspruch. Der Beitrag enthält eine Kurzdarstellung des biologisch-dynamischen Forschungsansatzes sowie eine Übersicht über biologisch-dynamische Forschungsprojekte im deutschsprachigen Raum

A European View of the Iraq Imbroglio

The University Archives has determined that this item is of continuing value to OSU's history.Dr. Immo Stabreit was born on 24 January 1933 in Rathenow/Havel in Germany. He grew up in Berlin and in 1951 he joined the junior class at Princeton College, where he majored in history as well as French and Spanish. He graduated (B.A. high honours) in 1953. This was followed by legal studies at the Free University of Berlin from 1953 to 1957, simultaneously working as a language teacher at the U.S. Army Education Center in Berlin. During the period from 1957 to 1962 he underwent legal training as a junior attorney while, at the same time, continuing his legal studies at Heidelberg University. In 1962 he passed the state examination, admitting him to the bar. He entered the Foreign Service of the Federal Republic of Germany in 1962, spending the year 1962/1963 as attaché at the German Embassy in Moscow. This was followed by a tour of duty with the Foreign Office at Bonn, where he served from 1964 to 1966 on the Soviet desk. In 1964 he was awarded his Doctor of Laws (LL.D) degree by Heidelberg University.Ohio State University. Mershon Center for International Security StudiesEvent webpage, phot

Numerical modelling of the coupling efficiency of single quantum emitters in photonic-crystal waveguides

Planar photonic nanostructures have recently attracted a great deal of attention for quantum optics applications. In this article, we carry out full 3D numerical simulations to fully account for all radiation channels and thereby quantify the coupling efficiency of a quantum emitter embedded in a photonic-crystal waveguide. We utilize mixed boundary conditions by combining active Dirichlet boundary conditions for the guided mode and perfectly-matched layers for the radiation modes. In this way, the leakage from the quantum emitter to the surrounding environment can be determined and the spectral and spatial dependence of the coupling to the radiation modes can be quantified. The spatial maps of the coupling efficiency, the $\beta$-factor, reveal that even for moderately slow light, near-unity $\beta$ is achievable that is remarkably robust to the position of the emitter in the waveguide. Our results show that photonic-crystal waveguides constitute a suitable platform to achieve deterministic interfacing of a single photon and a single quantum emitter, which has a range of applications for photonic quantum technology