Aspecte diagnostico-curative în managementul hiperparatiroidismului primar. Experienţa clinicii

Catedra 2 Chirurgie, USMF ,,N. Testemițanu”, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareIntroducere. Hiperparatiroidismul primar (HPP) se caracterizează prin secreţia exagerată de parathormon (PTH) şi dispariţia fenomenului de feedback dintre producţia PTH şi nivelul seric al calciului, acestea se datorează adenoamelor în 95% cazuri, în 5%-hiperplaziei paratiroidiene. Scopul. Aprecierea indicaţiilor pentru tratamentul chirugical şi eficacităţii acestuia în HPP. Material şi metode. În Clinica 2 Chirurgie pe parcursul anilor 2015-2020 au fost operaţi 76 pacienţi cu hiperparatiroidism primar. A fost efectuat un studiu retrospectiv asupra bolnavilor internaţi în secţia chirugie VAE, SCR în perioda 2015-2020, diagnosticaţi cu HPP primar. Pacienţii au fost evaluaţi clinic, paraclinic, imagistic şi tactica tratamentului. Rezultate. 76 de cazuri au fost cu HPP primar, 11 bărbaţi (14,47%) şi 65 femei (85,5%), cu o vârstă medie 50-70 ani. Ecografic, dimensiunea medie a paratiroidelor a fost de 1.0-3.0 cm. (figura 1a.) Toţi pacienţii au fost operaţi, înlăturânduse adenomul(figura 2.) Postoperator, s-a confirmat scăderea PTH şi normalizarea calciului seric. Morfologie: adenom paratiroidian benign 55(74,32%) (figura 3); hiperplazie paratiroidiană-19(25,67%) cazuri. Concluzii. Diagnosticul pozitiv al HPP implică dozarea caciului seric şi a PTH. Adenomul este localizat prin USG, tratamentul chirurgical este singurul tratament curativ al HPP, mortalitatea postoperatorie a fost nulă

A study of some fundamental physicochemical variables on the morphology of mesoporous silica nanoparticles MCM-41 type

[EN] All variables affecting the morphology of mesoporous silica nanoparticles (MSN) should be carefully analyzed in order to truly tailored design their mesoporous structure according to their final use. Although complete control on MCM-41 synthesis has been already claimed, reproducibility and repeatability of results remain a big issue due to the lack of information reported in literature. Stirring rate, reaction volume, and system configuration (i.e., opened or closed reactor) are three variables that are usually omitted, making the comparison of product characteristics difficult. Specifically, the rate of solvent evaporation is seldom disclosed, and its influence has not been previously analyzed. These variables were systematically studied in this work, and they were proven to have a fundamental impact on final particle morphology. Hence, a high degree of circularity (C = 0.97) and monodispersed particle size distributions were only achieved when a stirring speed of 500 rpm and a reaction scale of 500 mL were used in a partially opened system, for a 2 h reaction at 80 degrees C. Well-shaped spherical mesoporous silica nanoparticles with a diameter of 95 nm, a pore size of 2.8 nm, and a total surface area of 954 m(2) g(-1) were obtained. Final characteristics made this product suitable to be used in biomedicine and nanopharmaceutics, especially for the design of drug delivery systems.This study was funded partially by Departamento Administrativo de Ciencia Tecnología e Innovación–COLCIENCIAS (recipient, Angela A. Beltrán-Osuna); Ministerio de Economía y Competitividad, MINECO, research number MAT2016-76039-C4-1-R (Recipient, José L. Gómez-Ribelles); and Universidad Nacional de Colombia, grant number DIB201010021438 (Recipient, Jairo E. Perilla).Beltrán-Osuna, A.; Gómez Ribelles, JL.; Perilla-Perilla, JE. (2017). 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Functionalization of mesoporous MCM-41 with aminopropyl groups by co-condensation and grafting: a physico-chemical characterization

This work reports on the synthesis and characterization of NH2-MCM-41, a well-known hybrid material commonly used in biomedical and biotechnological applications, based on mesoporous silica and aminopropyl functionalities. Samples were prepared by post-synthesis grafting and by one-pot co- condensation methods, to achieve a relatively high organic loading (around 12% wt), and were characterized in terms of porosity, thermal stability and distribution of the aminopropyl moieties in the silica framework. The results suggest that grafting brings about an almost complete consumption of surface silanols, with structurally defined functional groups mainly located inside the material pores. In contrast, co-condensation results in lower surface area and thermal stability, with ink-bottle-like pores. This suggests that the aminopropyl groups are not only linked to the pores inner surface but could be located in the pore walls or at their entrance

Pd Nanoparticle Catalyzed Heck Arylation of 1,1-Disubstituted Alkenes in Ionic Liquids. Study on Factors Affecting the Regioselectivity of the Coupling Process

The Heck reaction of neutral or electron-rich aryl bromides with the 1,1-disubstituted olefins butyl methacrylate and R-methylstyrene catalyzed by Pd nanoparticles in tetrabutylammonium bromide as solvent and tetrabutylammonium acetate as base leads to a prevalent formation of the terminal olefin. In contrast, reaction of p-bromoacetophenone leads to the internal olefin. Whereas the solvent stabilizes the metal nanoclusters, the base is responsible for a fast neutralization of the PdH impeding the hydride readdition to reaction products and avoiding the olefin interconversion. The terminal olefins are efficiently converted into the more stable internal E isomers by using tetrabutylammonium pivalate as catalyst

Mesoporous silica as a carrier for topical application: the Trolox case study

As part of a recent research effort aimed at employing mesoporous materials for controlled drug delivery, this paper presents MCM-41 as a carrier for topical application, using Trolox as a model unstable guest molecule. The complexes between Trolox and MCM-41 were prepared by employing different inclusion procedures, varying solvent, method and pretreatment of the silica matrix. The objectives of this study were to determine Trolox loading, analyze its integrity and availability after immobilization on mesoporous silica, evaluate MCM-41 influence on Trolox photodegradation and establish whether the preparation method significantly influences complex properties. The characterization analyses (XRD, TGA, DSC and FTIR) confirmed the hydrogen-bonding interaction and Trolox structure preservation. Gas-volumetric analysis showed a consistent decrease in surface area and in pore volume and diameter with respect to bare MCM-41 indicating that Trolox was mainly located within mesopores. In vitro diffusion tests showed a slower release of Trolox after inclusion in the MCM-41 matrix; at the same time UV irradiation studies highlighted an increased photostability for the complex particularly in O/W emulsion. Moreover the radical scavenging activity of Trolox was maintained after immobilization. In all cases, differences were observed in all tested samples, suggesting that results could be optimized by modifying the inclusion procedure and by improving the guest loading