Hubungan supervisi akademik kepala Madrasah dengan profesionalisme guru : Penelitian pada guru di Madrasah Aliyah Negeri 1 Bandung

Supervisi akademik merupakan salah satu hal yang sangat penting dalam suatu lembaga pendidikan. Sebagai proses pengawasan kinerja guru untuk meningkatkan kualitas pembelajaran dan peningkatan kinerja guru secara profesional agar tercapai tujuan pendidikan. Dalam penyelenggaraan proses supervisi akademik di Madrasah Aliyah Negeri 1 Bandung masih ada beberapa hal yang menjadi permasalahan diantaranya: bagaimana tahap persiapan penyusunan format/instrumen supervisi, teknik supervisi yang paling efektif dilaksanakan, dan korelasi antara supervisi yang dilakukan dengan peningkatan profesionalisme guru. Penelitian ini bertujuan untuk mengetahui: (1) realitas supervisi akademik kepala madrasah di Madrasah Aliyah Negeri 1 Bandung, (2) realitas profesionalisme guru di Madrasah Aliyah Negeri 1 Bandung, (3) realitas hubungan antara supervisi akademik kepala madrasah dengan profesionalisme guru di Madrasah Aliyah Negeri 1 Bandung. Dalam penelitian ini, peneliti menggunakan metode penelitian kuantitatif, dengan metode deskriptif korelasioner. Data pada penelitian ini diperoleh melalui penyebaran angket, wawancara dan studi dokumentasi. Teknik analisis data pada penelitian ini menggunakan uji instrument (validitas dan reliabilitas), analisis parsial perindikator, penafsiran variabel, uji normalitas data, analisis korelasi dan koefisien determinasi. Berdasarkan analisis data dan hasil penelitian menunjukkan bahwa: (1) supervisi akademik kepala madrasah di Madrasah Aliyah Negeri 1 Bandung termasuk kualifikasi tinggi, karena berada pada interval 3,6 – 4,5 yaitu 4,33 (kualifikasi tinggi). (2) profesionalisme guru di Madrasah Aliyah Negeri 1 Bandung termasuk kualifikasi sangat tinggi, karena pada rentang interval 4,6 – 5,5 yaitu 4,57 (kualifikasi sangat tinggi). (3) hubungan antara supervisi akademik kepala madrasah dengan profesionalisme guru di Madrasah Aliyah Negeri 1 Bandung diperoleh nilai koefisien sebesar 0,562** atau 56,2%. Nilai tersebut termasuk korelasi kategori 0,40 – 0,59 yang artinya ada hubungan yang sedang atau cukup serta memiliki arah hubungan yang positif dan searah. Signifikansi antara keduanya diperoleh 0,000 < 0,05. Dengan demikian dapat disimpulkan bahwa Ha diterima, hal ini memberikan arti bahwa ada hubungan positif dan searah antara supervisi akademik kepala madrasah dengan profesionalisme guru di Madrasah Aliyah Negeri 1 Bandung. Koefisien determinasi diperoleh 31,6%, Angka tersebut mengisyaratkan bahwa profesionalisme guru di Madrasah Aliyah Negeri 1 Bandung 68,4% nya dipengaruhi oleh faktor lain

Amplification genetic engineering strategy by Crispr-Cas13 Enzymes for detection and treatment COVID-19 mediated with gold nanoparticle (AUNP)

WHO declared the disease outbreak due to the COVID-19 coronavirus a global pandemic. Indonesian government's efforts to eradicate the pandemic through mass screening have not been effective due to the limitations of the three main modalities used to detect COVID-19, including Rapid Test Diagnostic (RTD) antibodies, RTD antigens, and Reverse Transcriptase-Polymerase Chain Reaction (RT-RTD PCR), In addition, other detection tools are sometimes used, such as Enzyme-Linked Immunosorbent Assay (ELISA) and rapid molecular tests. To eradicate this pandemic, the government needs COVID-19 detection tools that are effective, cheap, fast, and accessible. To determine the application of the genetic engineering strategy of amplification by the CRISPR-cas13 enzyme for detecting and treating COVID-19 mediated by gold nanoparticles (AuNP). This research uses a qualitative literature study with content analysis, observation development, and literature study; an alternative solution to this problem is CRISPR-Cas13, achieved by the SHERLOCK method. This method designs and screens a targeted group of CRISPR RNAs based on the identification of functional crRNAs of SARS-CoV-2. Amplification of CRISPR-Cas13 by SHERLOCK and PAC-MAN enzymes has the potential to be the latest detection and treatment method for gold nanoparticle-mediated COVID-19 (AuNP) in Indonesia

CRISPR-Cas9 through AAV delivery system as a gene therapy in Parkinson’s disease

The global population living with Parkinson’s disease is estimated to reach 9.4 million people, which has increased significantly since 2016, with a total of 6 million people. Parkinson's is a neurodegenerative disease of the substantia nigra that causes a decrease in dopamine production and is characterized by the appearance of cytoplasmic misfold proteins called Lewy bodies. The study found that abnormalities or mutations in the SNCA and LRRK2 genes correlated with the overproduction of the ɑ-synuclein protein, which forms Lewy bodies that cause Parkinson's. Current Parkinson's medications only temporarily replace lost dopamine but do not treat the direct cause of Parkinson's; this research used qualitative literature study with content analysis, observation, and development; the use of CRISPR-Cas9 through AAV genetic engineering in repairing SNCA and LRRK2 mutant gene. This genetic therapy works by cutting the mutant DNA base sequences in the SNCA and LRRK2 genes and then replacing them with normal sequences through a homology-direct repair mechanism. As a result, the abnormalities or mutations that cause Parkinson's in these two genes can be corrected, so that dopaminergic levels in the brain can return to normal and excessive accumulation of α-synuclein protein can be suppressed

The Positive Effect of Four-Week Combined Aerobic–Resistance Training on Body Composition and Adipokine Levels in Obese Females

Obesity is a metabolic disease that is caused by a lack of physical activity and is associated with an increased risk of chronic inflammation. A total of 40 obese adolescent females with an average age of 21.93 ± 1.35 years and average body mass index (BMI) of 30.81 ± 3.54 kg/m2 were enrolled in this study, randomized, and divided into four groups, i.e., control (CTL; n = 10), moderate intensity aerobic training (MAT; n = 10), moderate intensity resistance training (MRT; n = 10), and moderate intensity combined aerobic–resistance training (MCT; n = 10). The enzyme-linked immunosorbent assay (ELISA) kits method was used to analyze the adiponectin and leptin levels between pre-intervention and post-intervention. Statistical analysis was conducted using a paired sample t-test, while correlation analysis between variables used the Pearson product–moment correlation test. Research data showed that MAT, MRT, and MCT significantly increased adiponectin levels and decreased leptin levels compared to the CTL (p ≤ 0.05). The results of the correlation analysis of delta (∆) data showed that an increase in adiponectin levels was significantly negatively correlated with a decrease in body weight (BW) (r = −0.671, p ≤ 0.001), BMI (r = −0.665, p ≤ 0.001), and fat mass (FM) (r = −0.694, p ≤ 0.001) and positively correlated with an increase in skeletal muscle mass (SMM) (r = 0.693, p ≤ 0.001). Whereas, a decrease in leptin levels was significantly positively correlated with a decrease in BW (r = 0.744, p ≤ 0.001), BMI (r = 0.744, p ≤ 0.001), and FM (r = 0.718, p ≤ 0.001) and negatively correlated with an increase in SMM (r = −0.743, p ≤ 0.001). In summary, it can be concluded that our data show that adiponectin levels increased and leptin levels decreased after the intervention of aerobic, resistance, and combined aerobic–resistance training