An Innovative Methodology to Optimize Aerospace Eco-efficiency Assembly Processes

Sustainability and eco-efficiency have been researched in multiple scientific papers since the last years. However the literature is not so abundant when applying those concepts to industrial assembly processes. This paper presents an innovate methodology to optimize aerospace assembly processes. Authors propose the introduction of a new element, the eco-efficiency, along with the traditional criteria, cost and time, currently used for optimization. Using a large Aero-Structure as an industrial case of study, the methodology analyzes the eco-efficiency of an assembly process in connection with a Life Cycle Assessment (LCA) to compute the environmental impact. Results are shown in a dashboard along with the relevant Key Process Indicator (KPI) to help the engineers to select the best assembly processEuropean Union (UE). H2020 DILECO 785367European Union H2020-EU.3.4.5.4-IT

Curative Chemoradiotherapy of Primary Pancreatic Lymphoma with Vertebral Metastasis: Palliation of Persistent Biliary Stricture by Roux-en-Y Hepaticojejunostomy

Primary pancreatic lymphoma (PPL) is a rare tumor that usually presents with the clinical picture of advanced adenocarcinoma but has a much better prognosis. A 38-year-old man was referred after percutaneous transhepatic external biliary drainage for obstructive jaundice. Abdominal magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography had revealed a 5-cm pancreatic head mass that caused biliary tract dilation. Computed tomography angiography showed that the mass encased the celiac trunk as well as the common hepatic and splenic arteries. MRI also revealed a metastatic lesion at the third lumbar vertebra. Serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels were within normal range. The initial diagnosis was inoperable pancreatic adenocarcinoma; however, Tru-Cut pancreatic biopsy showed a large B cell lymphoma. After 6 sessions of chemotherapy and 21 sessions of radiotherapy, both the pancreatic mass and the vertebral metastasis had disappeared. However, he had persistent distal common bile duct stricture that could not be negotiated by either the endoscopic or percutaneous route. A Roux-en-Y hepaticojejunostomy was performed. The patient stayed alive without recurrence for 52 months after the initial diagnosis and 45 months after completion of oncologic treatment. In conclusion, a large pancreatic mass with grossly involved peripancreatic lymph nodes, without ascites, liver or splenic metastasis, should alert the clinician to the possibility of PPL. Cure is possible by chemoradiotherapy even in the presence of vertebral metastasis. Persistent stricture in the distal common bile duct may require a biliodigestive anastomosis

Proteomics of spatially identified tissues in whole organs

Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states. However, methods for molecular analysis of biological specimens imaged in 3D as a whole are lacking. Here, we present DISCO-MS, a technology combining whole-organ imaging, deep learning-based image analysis, and ultra-high sensitivity mass spectrometry. DISCO-MS yielded qualitative and quantitative proteomics data indistinguishable from uncleared samples in both rodent and human tissues. Using DISCO-MS, we investigated microglia activation locally along axonal tracts after brain injury and revealed known and novel biomarkers. Furthermore, we identified initial individual amyloid-beta plaques in the brains of a young familial Alzheimer’s disease mouse model, characterized the core proteome of these aggregates, and highlighted their compositional heterogeneity. Thus, DISCO-MS enables quantitative, unbiased proteome analysis of target tissues following unbiased imaging of entire organs, providing new diagnostic and therapeutic opportunities for complex diseases, including neurodegeneration

Early-stage [123I]beta-CIT SPECT and long-term clinical follow-up in patients with an initial diagnosis of Parkinson's disease

beta-CIT binding in both caudate nuclei was lower than in the group of patients with IPD. In addition, putamen to caudate binding ratios were higher in the group of APS patients. In spite of these differences, individual binding values showed considerable overlap between the groups. CONCLUSION: [(123)I]beta-CIT SPECT scanning in early-stage, untreated parkinsonian patients revealed a relative sparing of the caudate nucleus in patients with IPD as compared to patients later (re)diagnosed with APS. Nevertheless, the pattern of striatal involvement appears to have little predictive value for a later re-diagnosis of APS in individual case

A proposal for the classification of structural systems of tall buildings

In the early structures at the beginning of the 20th century, structural members were assumed to carry primarily the gravity loads. Today, however, by the advances in structural design/systems and high-strength materials, building weight is reduced, and slenderness is increased, which necessitates taking into consideration mainly the lateral loads such as wind and earthquake. Understandably, especially for the tall buildings, as the slenderness, and so the flexibility increases, buildings suffer from the lateral loads resulting from wind and earthquake more and more. As a general rule, when other things being equal, the taller the building, the more necessary it is to identify the proper structural system for resisting the lateral loads. Currently, there are many structural systems that can be used for the lateral resistance of tall buildings. In this context, authors classify these systems based on the basic reaction mechanism/structural behavior for resisting the lateral loads