The Heidelberg Catechism: An Ecumenical Confession

This booklet prints the Founders\u27 Day address delivered by Dr. James Iley McCord at Ursinus College on November 4, 1962. The speech details the distinguishing characteristics of the Heidelberg Catechism. The booklet also contains an outline of Zacharias Ursinus\u27 educational career as well as a history of educational institutions in Collegeville.https://digitalcommons.ursinus.edu/founders_programs/1069/thumbnail.jp

An alkylation route to carbo- and heteroaromatic amino acids

Amino acids carrying aromatic carbo- and heterocycles in the side chain, such as naphthyl-, biphenyl- and pyridylalanines, have been prepared by alkylation of a glycine enolate with a haloalkyl carbocycle or heterocycle, with enantiomeric excess up to 87% using the ephedrine amide protocol

Intermolecular 1,3-dipolar cycloadditions of azomethine imines

Dipolar cycloadditions of azomethine imines, formed in situ from aldehydes and N1-alkyl-N2-acylhydrazines, with electron-deficient dipolarophiles produce pyrazolidines: mono-substituted dipolarophiles afford principally 4-substituted pyrazolidines

Synthesis of some new 2-heterosubstituted 4,5-dihydroimidazoles

Several new 4,5-dihydroimidazoles (and the corresponding imidazolium salts) carrying heteroatom substituents at C-2 have been prepared from the corresponding tetrahydroimidazol-2-ones and/or -thiones

A catalytic dipolar cycloaddition route to pyrroloimidazoles

A catalytic method involving carbenoid insertion onto dihydroimidazoles is reported for the generation of dihydroimidazolium ylides, and their subsequent diastereoselective cycloaddition to form pyrrolo[1,2-a]imidazole

Teaching open and reproducible scholarship: A critical review of the evidence base for current pedagogical methods and their outcomes

In recent years, the scientific community has called for improvements in the credibility, robustness and reproducibility of research, characterized by increased interest and promotion of open and transparent research practices. While progress has been positive, there is a lack of consideration about how this approach can be embedded into undergraduate and postgraduate research training. Specifically, a critical overview of the literature which investigates how integrating open and reproducible science may influence student outcomes is needed. In this paper, we provide the first critical review of literature surrounding the integration of open and reproducible scholarship into teaching and learning and its associated outcomes in students. Our review highlighted how embedding open and reproducible scholarship appears to be associated with (i) students' scientific literacies (i.e. students’ understanding of open research, consumption of science and the development of transferable skills); (ii) student engagement (i.e. motivation and engagement with learning, collaboration and engagement in open research) and (iii) students' attitudes towards science (i.e. trust in science and confidence in research findings). However, our review also identified a need for more robust and rigorous methods within pedagogical research, including more interventional and experimental evaluations of teaching practice. We discuss implications for teaching and learning scholarship

Teaching open and reproducible scholarship: a critical review of the evidence base for current pedagogical methods and their outcomes

In recent years, the scientific community has called for improvements in the credibility, robustness, and reproducibility of research, characterized by increased interest and promotion of open and transparent research practices. While progress has been positive, there is a lack of consideration about how this approach can be embedded into undergraduate and postgraduate research training. Specifically, a critical overview of the literature which investigates how integrating open and reproducible science may influence student outcomes is needed. In this paper, we provide the first critical review of literature surrounding the integration of open and reproducible scholarship into teaching and learning and its associated outcomes in students. Our review highlighted how embedding open and reproducible scholarship appears to be associated with (1) students’ scientific literacies (i.e., students’ understanding of open research, consumption of science, and the development of transferable skills); (2) student engagement (i.e., motivation and engagement with learning, collaboration, and engagement in open research), and (3) students’ attitudes towards science (i.e., trust in science and confidence in research findings). However, our review also identified a need for more robust and rigorous methods within pedagogical research, including more interventional and experimental evaluations of teaching practice. We discuss implications for teaching and learning scholarship

Development of novel DNA-binding chemotherapeutic agents based on flavonoid scaffolds of active ingredients isolated from Chinese herbal remedies

Herbal remedies and traditional medicines of ethnic origin have been the source of libraries of active ingredients that have found use in the development of modern medicines for a number of diseases including cancer. Such compounds have shown proven anticancer activity against various cancer cell lines according to the Developmental Therapeutics Programme of the NCI. This project utilises a group of active ingredients isolated from Traditional Chinese herbal medicines as a scaffold (see figure below), in an attempt to devise molecules that interact with DNA selectively and can act as novel chemotherapeutic agents. The interactions of duplex genomic DNA and synthetic polynucleotides, as well as triplex and tetraplex DNA polymorphs with the unmodified compounds have been studied using different analytical techniques. This study is based on experiments including spectroscopic analysis such as UV, ethidium bromide displacement and thermal denaturation, as well as biological tests like cell viability, flow cytometry, comet assay and topoisomerase I & II assays. This battery of tests ascertained the presence of DNA binding activity for these compounds and provided an estimate of their association constants with the various forms of DNA. These were found to be in the order of 104 M-1 – 105 M-1 depending on the compound and the form of DNA, and provided information on the binding preference of the drug molecules. Baicalein showed specificity for AT bases and especially pyrimidine triplex and tetraplex formations, and was characterized by activity against the MCF7 breast cancer cell line. Quercetin showed interaction with tetraplex DNA, purine and pyrimidine triplexes, as well as AT – GC bases and also presented activity against the CCRFCEM leukemia cell line. Daidzein has low specificity for GC bases, whereas baicalin, puerarin and rutin interact weakly with the various nucleic acid structures. As daidzein is considered a phytoestrogen, it promotes activity where estrogen receptors are located, as was shown by the promotion of growth in MCF7 cell line. In flavonoids, the planarity of the molecule allows the molecule to intercalate between the nucleobases. Furthermore, in the case of quercetin, the hydroxyl groups in R3, R5 and R6 seem to have a strong influence on the interaction with DNA. Based on these results, we studied further modifications of the molecules and their effect on DNA-binding.We found substitutions on the A and B rings to be important as they increase the binding by an order of magnitude; the position of the B ring is also relevant, in C2 improves the binding, and in C3 decreases it. The absence of the C2-C3 double bond makes a distortion to the planarity of the molecule, which appears to decrease the activity. The acetoxy groups in positions 5 and 7 appear to reduce the binding values. These results, together with molecular modeling; will allow the synthesis of novel molecules that bind selectively to nucleic acids and have improved anticancer activity and pharmacological properties

Kinetics and mechanism of N-amidomethylsulfonamides

The kinetics of the hydrolyses of secondary and tertiary N-amidomethylsulfonamides were studied at 50 C. Both types of N-amidomethylsulfonamide hydrolyse through acid- and base-catalysed processes, as indicated by the pH–rate profiles. The order of reactivity for the acid-catalysed pathway implies a mechanism involving protonation of the amide followed by expulsion of a neutral amide and formation of a sulfonyliminium ion. In the base-catalysed region, compound 5c, which is substituted at both amide and sulfonamide nitrogen atoms, hydrolyses by nucleophilic attack of hydroxide ion at the amide carbonyl carbon atom to form benzoic acid and a sulfonamide. In contrast, compound 5b, which contains a sulfonamide NH group, hydrolyses to benzamide and sulfonamide products by an E1cbrev mechanism involving ionisation of the sulfonamide. Compound 5a, which contains an amide NH, also hydrolyses to sulfonamide and amide products, probably by an E2 mechanism

Correlations between the general aptitude test battery scores, curriculum selections, and jobs obtained by students of the Texas State Technical Institute

Purpose for the Study: The study sought to answer two basic questions: (1). Does scoring high on the General Aptitude Test Battery (GATB) have a significant effect on success in graduation? (2). Do the graduates of Texas State Technical Institute obtain jobs for which they have been trained at school? Scope of the Study: In answering the first question, the GATB scores of 2,357 students were compiled. These were students who were enrolled in Texas State Technical Institute, Waco, Texas, in the period of time between September, 1966 through April, 1973. In answering the second question, the responses to 550 survey letters from selected graduates were treated to statistical analysis. Procedure of the Study: In Phase I, a Chi Square analysis was performed to determine if graduation depended on scoring high on the GATB. The t statistic was used to compare the number of times the GATB scores were significant with the times the scores were not significant. In Phase II, a factorial analysis was done to determine if scoring high on the GATB had a significant relationship with the graduate finding related employment. Also, the t test for the significance of difference between means, where population variances are unequal, was performed to determine if there was a significant difference between the number of graduates who found related employment and those who did not find related employment