Jewish names in Egypt in the Early Roman period

In this article I claim that in the Roman period, biblical names used by Jews became very limited in comparison with their variety in the Ptolemaic period. I argue that they are mainly represented by the names of the three patriarchs - Abraham, Isaac and Jacob - and of Jacob's son - Joseph. These four names constitute 73% of all biblical names male Jews used in the early Roman period, before the Jewish revolt in 115-117 A.D

RF plugging of multi-mirror machines

One of the main challenges of fusion reactors based on magnetic mirrors is the axial particle loss through the loss cones. In multi-mirror (MM) systems, the particle loss is addressed by adding mirror cells on each end of the central fusion cell. Coulomb collisions in the MM sections serve as the retrapping mechanism for the escaping particles. Unfortunately, the confinement time in this system only scales linearly with the number of cells in the MM sections and requires an unreasonably large number of cells to satisfy the Lawson criterion. Here, it is suggested to reduce the outflow by applying a traveling RF electric field that mainly targets the particles in the outgoing loss cone. The Doppler shift compensates for the detuning of the RF frequency from the ion cyclotron resonance mainly for the escaping particles resulting in a selectivity effect. The transition rates between the different phase space populations are quantified via single-particle calculations and then incorporated into a semi-kinetic rate equations model for the MM system, including the RF effect. It is found that for optimized parameters, the confinement time can scale exponentially with the number of MM cells, orders of magnitude better than a similar MM system of the same length but without the RF plugging, and can satisfy the Lawson criterion for a reasonable system size

Harnessing Soluble NK Cell Killer Receptors for the Generation of Novel Cancer Immune Therapy

The natural cytotoxic receptors (NCRs) are a unique set of activating proteins expressed mainly on the surface of natural killer (NK) cells. The NCRs, which include three members; NKp46, NKp44 and NKp30, are critically involved in NK cytotoxicity against different targets, including a wide range of tumor cells derived from various origins. Even though the tumor ligands of the NCRs have not been identified yet, the selective manner by which these receptors target tumor cells may provide an excellent basis for the development of novel anti-tumor therapies. To test the potential use of the NCRs as anti-tumor agents, we generated soluble NCR-Ig fusion proteins in which the constant region of human IgG1 was fused to the extracellular portion of the receptor. We demonstrate, using two different human prostate cancer cell lines, that treatment with NKp30-Ig, dramatically inhibits tumor growth in vivo. Activated macrophages were shown to mediate an ADCC response against the NKp30-Ig coated prostate cell lines. Finally, the Ig fusion proteins were also demonstrated to discriminate between benign prostate hyperplasia and prostate cancer. This may provide a novel diagnostic modality in the difficult task of differentiating between these highly common pathological conditions

Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10

Ubiquitylation is a posttranslational modification that determines protein fate. The ubiquitin code is written by enzymatic cascades of E1 and E2 and E3 enzymes. Ubiquitylation can be edited or erased by deubiquitylating enzymes. Ub-receptors are proteins that read and decipher the ubiquitin codes into cellular response. They harbor a ubiquitin-binding domain and a response element. Interestingly, Ub-receptors are also regulated by ubiquitylation and deubiquitylation. However, until recently, the molecular details and the significance of this regulation remained enigmatic. Rpn10 is a Ub-receptor that shuttles ubiquitylated targets to the proteasome for degradation. Here we review recent data on Rpn10, with emphasis on its regulation by ubiquitylation

One-Way Functions and (Im)perfect Obfuscation

A program obfuscator takes a program and outputs an scrambled version of it, where the goal is that the obfuscated program will not reveal much about its structure beyond what is apparent from executing it. There are several ways of formalizing this goal. Specifically, in indistinguishability obfuscation, first defined by Barak et al. (CRYPTO 2001), the requirement is that the results of obfuscating any two functionally equivalent programs (circuits) will be computationally indistinguishable. Recently, a fascinating candidate construction for indistinguishability obfuscation was proposed by Garg et al. (FOCS 2013). This has led to a flurry of discovery of intriguing constructions of primitives and protocols whose existence was not previously known (for instance, fully deniable encryption by Sahai and Waters, STOC 2014). Most of them explicitly rely on additional hardness assumptions, such as one-way functions. Our goal is to get rid of this extra assumption. We cannot argue that indistinguishability obfuscation of all polynomial-time circuits implies the existence of one-way functions, since if $P = NP$, then program obfuscation (under the indistinguishability notion) is possible. Instead, the ultimate goal is to argue that if $P \neq NP$ and program obfuscation is possible, then one-way functions exist. Our main result is that if $NP \not\subseteq ioBPP$ and there is an efficient (even imperfect) indistinguishability obfuscator, then there are one-way functions. In addition, we show that the existence of an indistinguishability obfuscator implies (unconditionally) the existence of SZK-arguments for $NP$. This, in turn, provides an alternative version of our main result, based on the assumption of hard-on-the average $NP$ problems. To get some of our results we need obfuscators for simple programs such as 3CNF formulas