Sequential Formation of Low-Mass Stars in the BRC 14 Region

We have carried out a deep near-infrared survey of a bright-rimmed molecular cloud, BRC 14 (IC 1848A). The 10 sigma limiting magnitude of the survey is 17.7 mag at the K-band. Seventy-four sources are classified as young stellar object (YSO) candidates based on the near-infrared color-color diagram. The faintest YSO candidates may have masses of an order of tenths of the solar mass, assuming the age of 1 Myr. We examined three values as indicators of star formation; fraction of the YSO candidates, extinctions of all sources, and near-infrared excesses of the YSO candidates. All indicators increase from outside of the rim to the center of the molecular cloud, which suggests that the formation of the low-mass stars in the BRC 14 region proceeds from outside to the center of the cloud.Comment: 12 pages, 5 figures, 1 table, PASJ accepte

TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF-κB Signaling

Many of the tripartite motif (TRIM) proteins function as E3 ubiquitin ligases and are assumed to be involved in various events, including oncogenesis. In regard to tripartite motif-containing 44 (TRIM44), which is an atypical TRIM family protein lacking the RING finger domain, its pathophysiological significance in breast cancer remains unknown. We performed an immunohistochemical study of TRIM44 protein in clinical breast cancer tissues from 129 patients. The pathophysiological role of TRIM44 in breast cancer was assessed by modulating TRIM44 expression in MCF-7 and MDA-MB-231 breast cancer cells. TRIM44 strong immunoreactivity was significantly associated with nuclear grade (p = 0.033), distant disease-free survival (p = 0.031) and overall survival (p = 0.027). Multivariate analysis revealed that the TRIM44 status was an independent prognostic factor for distant disease-free survival (p = 0.005) and overall survival (p = 0.002) of patients. siRNA-mediated TRIM44 knockdown significantly decreased the proliferation of MCF-7 and MDA-MB-231 cells and inhibited the migration of MDA-MB-231 cells. Microarray analysis and qRT–PCR showed that TRIM44 knockdown upregulated CDK19 and downregulated MMP1 in MDA-MB-231 cells. Notably, TRIM44 knockdown impaired nuclear factor-kappa B (NF-κB)-mediated transcriptional activity stimulated by tumor necrosis factor α (TNFα). Moreover, TRIM44 knockdown substantially attenuated the TNFα-dependent phosphorylation of the p65 subunit of NF-κB and IκBα in both MCF-7 and MDA-MB-231 cells. TRIM44 would play a role in the progression of breast cancer by promoting cell proliferation and migration, as well as by enhancing NF-κB signaling

Correction to: Intracellular hypoxia measured by F-18 fluoromisonidazole positron emission tomography has prognostic impact in patients with estrogen-receptor positive breast (BRCR-D17-00693)

After the publication of this article [1], we noticed that in Fig. 2, the survival curve images (C and D, lower panel) were incorrect. The corrected Fig. 2 is presented below. The correction does not affect in any our results and conclusions

Additional file 1: of Intracellular hypoxia measured by 18F-fluoromisonidazole positron emission tomography has prognostic impact in patients with estrogen receptor-positive breast cancer

Figure S1. Correlation between tumor FMISO-SUVmax and FMISO-TBR. Regression plots between tumor FMISO-SUVmax and FMISO-TBR showed high correlation at r = 0.94. (TIF 66 kb