Small Cell Neuroendocrine Carcinoma of the Larynx: A Case Report and Literature Review

WOS: 000396412600024A small cell neuroendocrine neoplasm of the larynx is a very rare and aggressive type of malignancy. Neuroendocrine carcinomas are most frequently seen in the lungs. The larynx is the most frequently involved site in the head and neck. Primary small cell neuroendocrine carcinoma of the larynx constitutes less than 0.5% of all laryngeal cancers. This paper reports a case of a 41-year-old-male patient who presented with a poorly differentiated neuroendocrine carcinoma of the supraglottic larynx

Evaluation Of Autoinflammatory Disease Genes In Nasal Polyposis

Background/aim: To investigate cold-induced autoinflammatory syndrome 1 (CIAS1) gene polymorphisms that cause autoinflammatory diseases in patients with nasal polyposis (NP). Materials and methods: The study included 30 patients diagnosed with NP and 30 healthy age-matched individuals as a control group. CIAS1 polymorphisms were assessed by DNA sequence analysis. Patients with nasal polyps and the control group were compared in terms of gene polymorphisms. Each of the 8 polymorphisms of the CIAS1 gene was analyzed separately in the patient group. Results: The most frequently observed polymorphisms in the patient group were c.732G > A in 83%, c.663C > T in 23%, and c.1308C > A in 23% of the patients. c.732G > A polymorphism was evaluated separately. Guanine was transformed to adenine at the 732nd nucleotide position of the CIAS1 gene in the cDNA of chromosome 1. Conclusion: The CIAS1 gene c.732G > A polymorphism was thought to be responsible for an increase in disease susceptibility. The frequency of the "A" allele is higher in the patient group compared to the control group. Autoinflammatory diseases seem like a candidate to be one of these factors. This is the first report to define the role of autoinflammatory diseases among these factors.WoSScopu