Why Librarianship? A Comparative Study Between University of Tsukuba, University of Hong Kong, University of British Columbia and Shanghai University

Career decisions are motivated in part by our internal values, but also are influenced strongly by innumerable external forces perceived in the context of our lives. In the research reported here, we explore various social, cultural, economic, and educational factors, as well as personal and professional reasons that influence students in choosing library and information science professions as a career. Master of Library and Information Science (MLIS) students from four universities located in four different regions were invited to take part in an online questionnaire survey. The universities were Shanghai University (SHU), the University of British Columbia (UBC), the University of Hong Kong (HKU) and the University of Tsukuba (UT). 175 self-completed questionnaires were collected in total. Survey results indicated that students enrolled in MLIS programmes were predominately female. Differences and similarities were encountered for the different sites. For example HKU and UBC had the largest number of students with graduate-level qualifications prior to entering the MLIS programme and students at HKU and UBC tended to vary widely in terms of their educational and occupational backgrounds. For the majority of the HKU and UBC respondents, the decision to obtain a professional qualification in LIS was driven by the desire to maximize the benefits of a career change or for career advancement, while the majority of respondents at the UT and SHU did not already have a job or much working experience. While the total surveyed populations are small; the study will be of interest and value to LIS educators and administrators responsible for recruiting MLIS graduates and hiring LIS professions.postprin

The Millennium Arecibo 21-CM Absorption Line Survey. II. Properties of the Warm and Cold Neutral Media

We use the Gaussian-fit results of Paper I to investigate the properties of interstellar HI in the Solar neighborhood. The Warm and Cold Neutral Media (WNM and CNM) are physically distinct components. The CNM spin temperature histogram peaks at about 40 K. About 60% of all HI is WNM. At z=0, we derive a volume filling fraction of about 0.50 for the WNM; this value is very rough. The upper-limit WNM temperatures determined from line width range upward from about 500 K; a minimum of about 48% of the WNM lies in the thermally unstable region 500 to 5000 K. The WNM is a prominent constituent of the interstellar medium and its properties depend on many factors, requiring global models that include all relevant energy sources, of which there are many. We use Principal Components Analysis, together with a form of least squares fitting that accounts for errors in both the independent and dependent parameters, to discuss the relationships among the four CNM Gaussian parameters. The spin temperature T_s and column density N(HI) are, approximately, the two most important eigenvectors; as such, they are sufficient, convenient, and physically meaningful primary parameters for describing CNM clouds. The Mach number of internal macroscopic motions for CNM clouds is typically 2.5, but there are wide variations. We discuss the historical tau-T_s relationship in some detail and show that it has little physical meaning. We discuss CNM morphology using the CNM pressure known from UV stellar absorption lines. Knowing the pressure allows us to show that CNM structures cannot be isotropic but instead are sheetlike, with length-to-thickness aspect ratios ranging up to about 280. We present large-scale maps of two regions where CNM lies in very large ``blobby sheets''.Comment: Revised submission to Ap.J. Changes include: (1) correction of turbulent Mach number in equation 16 and figure 12; the new typical value is 1.3 versus the old, incorrect value 2.5. (2) smaller typeface for the astro-ph version to conserve paper. 60 pages, 16 figure

A complete classification of spherically symmetric perfect fluid similarity solutions

We classify all spherically symmetric perfect fluid solutions of Einstein's equations with equation of state p/mu=a which are self-similar in the sense that all dimensionless variables depend only upon z=r/t. For a given value of a, such solutions are described by two parameters and they can be classified in terms of their behaviour at large and small distances from the origin; this usually corresponds to large and small values of z but (due to a coordinate anomaly) it may also correspond to finite z. We base our analysis on the demonstration that all similarity solutions must be asymptotic to solutions which depend on either powers of z or powers of lnz. We show that there are only three similarity solutions which have an exact power-law dependence on z: the flat Friedmann solution, a static solution and a Kantowski-Sachs solution (although the latter is probably only physical for a1/5, there are also two families of solutions which are asymptotically (but not exactly) Minkowski: the first is asymptotically Minkowski as z tends to infinity and is described by one parameter; the second is asymptotically Minkowski at a finite value of z and is described by two parameters. A complete analysis of the dust solutions is given, since these can be written down explicitly and elucidate the link between the z>0 and z<0 solutions. Solutions with pressure are then discussed in detail; these share many of the characteristics of the dust solutions but they also exhibit new features.Comment: 63 pages. To appear in Physical Review

One-step isolation and biochemical characterization of a highlyactive plant PSII monomeric core

We describe a one-step detergent solubilization protocol for isolating a highly active form of Photosystem II (PSII) from Pisum sativum L. Detailed characterization of the preparation showed that the complex was a monomer having no light harvesting proteins attached. This core reaction centre complex had, however, a range of low molecular mass intrinsic proteins as well as the chlorophyll binding proteins CP43 and CP47 and the reaction centre proteins D1 and D2. Of particular note was the presence of a stoichiometric level of PsbW, a low molecular weight protein not present in PSII of cyanobacteria. Despite the high oxygen evolution rate, the core complex did not retain the PsbQ extrinsic protein although there was close to a full complement of PsbO and PsbR and partial level of PsbP. However, reconstitution of PsbP and PsbPQ was possible. The presence of PsbP in absence of LHCII and other chlorophyll a/b binding proteins confirms that LHCII proteins are not a strict requirement for the assembly of this extrinsic polypeptide to the PSII core in contrast with the conclusion of Caffarri et al. (2009)

Control of star formation by supersonic turbulence

Understanding the formation of stars in galaxies is central to much of modern astrophysics. For several decades it has been thought that stellar birth is primarily controlled by the interplay between gravity and magnetostatic support, modulated by ambipolar diffusion. Recently, however, both observational and numerical work has begun to suggest that support by supersonic turbulence rather than magnetic fields controls star formation. In this review we outline a new theory of star formation relying on the control by turbulence. We demonstrate that although supersonic turbulence can provide global support, it nevertheless produces density enhancements that allow local collapse. Inefficient, isolated star formation is a hallmark of turbulent support, while efficient, clustered star formation occurs in its absence. The consequences of this theory are then explored for both local star formation and galactic scale star formation. (ABSTRACT ABBREVIATED)Comment: Invited review for "Reviews of Modern Physics", 87 pages including 28 figures, in pres

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes—aggregation of the amyloid- (A ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)—are hallmarks of the disease. However, other pathological brain processes are thought to be key disease mediators of A plaque and NFT pathology. How these additional pathologies evolve over the course of the disease is currently unknown. Here we show that proteomic measurements in autosomal dominant AD cerebrospinal fluid (CSF) linked to brain protein coexpression can be used to characterize the evolution of AD pathology over a timescale spanning six decades. SMOC1 and SPON1 proteins associated with A plaques were elevated in AD CSF nearly 30 years before the onset of symptoms, followed by changes in synaptic proteins, metabolic proteins, axonal proteins, inflammatory proteins and finally decreases in neurosecretory proteins. The proteome discriminated mutation carriers from noncarriers before symptom onset as well or better than A and tau measures. Our results highlight the multifaceted landscape of AD pathophysiology and its temporal evolution. Such knowledge will be critical for developing precision therapeutic interventions and biomarkers for AD beyond those associated with A and tau

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease

Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-& beta;(A & beta;) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)-are hallmarks of the disease. However, other pathological brain processes are thought to be key disease mediators of A & beta;plaque and NFT pathology. How these additional pathologies evolve over the course of the disease is currently unknown. Here we show that proteomic measurements in autosomal dominant AD cerebrospinal fluid (CSF) linked to brain protein coexpression can be used to characterize the evolution of AD pathology over a timescale spanning six decades. SMOC1 and SPON1 proteins associated with A & beta;plaques were elevated in AD CSF nearly 30 years before the onset of symptoms, followed by changes in synaptic proteins, metabolic proteins, axonal proteins, inflammatory proteins and finally decreases in neurosecretory proteins. The proteome discriminated mutation carriers from noncarriers before symptom onset as well or better than A & beta;and tau measures. Our results highlight the multifaceted landscape of AD pathophysiology and its temporal evolution. Such knowledge will be critical for developing precision therapeutic interventions and biomarkers for AD beyond those associated with A & beta;and tau. Proteomic analysis of cerebrospinal fluid from individuals with autosomal dominant Alzheimer's disease reveals how this complex and chronic disease evolves over many decades

Update of complications and functional outcome of the ileo-pouch anal anastomosis: overview of evidence and meta-analysis of 96 observational studies

Item does not contain fulltextOBJECTIVE: The objective of this study is to provide a comprehensive update of the outcome of the ileo-pouch anal anastomosis (IPAA). DATA SOURCES: An extensive search in PubMed, EMBASE, and The Cochrane Library was conducted. STUDY SELECTION AND DATA EXTRACTION: All studies published after 2000 reporting on complications or functional outcome after a primary open IPAA procedure for UC or FAP were selected. Study characteristics, functional outcome, and complications were extracted. DATA SYNTHESIS: A review with similar methodology conducted 10 years earlier was used to evaluate developments in outcome over time. Pooled estimates were compared using a random-effects logistic meta-analyzing technique. Analyses focusing on the effect of time of study conductance, centralization, and variation in surgical techniques were performed. RESULTS: Fifty-three studies including 14,966 patients were included. Pooled rates of pouch failure and pelvic sepsis were 4.3% (95% CI, 3.5-6.3) and 7.5% (95% CI 6.1-9.1), respectively. Compared to studies published before 2000, a reduction of 2.5% was observed in the pouch failure rate (p = 0.0038). Analysis on the effect of the time of study conductance confirmed a decline in pouch failure. Functional outcome remained stable over time, with a 24-h defecation frequency of 5.9 (95% CI, 5.0-6.9). Technical surgery aspects did not have an important effect on outcome. CONCLUSION: This review provides up to date outcome estimates of the IPAA procedure that can be useful as reference values for practice and research. It is also shows a reduction in pouch failure over time.1 juli 201

Formation and Evolution of Early-Type Galaxies. III Star formation history as a function of mass and over-density

We investigate the influence of the initial proto-galaxies over-densities and masses on their evolution, to understand whether the internal properties of the proto-galactic haloes are sufficient to account for the varied properties of the galactic populations. By means of fully hydrodynamical N-body simulations performed with the code EvoL we produce twelve self-similar models of early-type galaxies of different initial masses and over-densities, following their evolution from z \geq 20 down to z \leq 1. The simulations include radiative cooling, star formation, stellar energy feedback, a reionizing photoheating background, and chemical enrichment of the ISM. We find a strong correlation between the initial properties of the proto-haloes and their star formation histories. Massive (10^13M\odot) haloes experience a single, intense burst of star formation (with rates \geq 10^3M\odot/yr) at early epochs, consistently with observations, with a less pronounced dependence on the initial over-density; intermediate mass (10^11M\odot) haloes histories strongly depend on their initial over-density, whereas small (10^9M\odot) haloes always have fragmented histories, resulting in multiple stellar populations, due to the "galactic breathing" phenomenon. The galaxy models have morphological, structural and photometric properties comparable to real galaxies, often closely matching the observed data; even though some disagreement is still there, likely a consequence of some numerical choices. We conclude that internal properties are essentially sufficient to explain many of the observed features of early type galaxies, particularly the complicated and different star formation histories shown by haloes of very different mass. In this picture, nature seems to play the dominant role, whereas nurture has a secondary importance.Comment: 27 pages, 25 figures, 5 table