Increase of Recognizable Label Number with Optical Passive Waveguide Circuits for Recognition of Encoded 4- and 8-Bit BPSK Labels

Optical label processing is expected to reduce power consumption in label switching network nodes. Previously, we proposed passive waveguide circuits for the recognition of BPSK labels with a theoretically infinite contrast ratio. The recognizable label number was limited to four and eight for 4-bit and 8-bit BPSK labels, respectively. In this paper, we propose methods to increase the recognizable label number. The proposed circuits can recognize eight and sixteen labels of 4-bit BPSK codes with a contrast ratio of 4.00 and 2.78, respectively. As 8-bit BSPK codes, 64, 128, and 256 labels can be recognized with a contrast ratio of 4.00, 2.78, and 1.65, respectively. In recognition of all encoded labels, that is, 16 and 256 labels for 4-bit and 8-bit BPSK labels, a reference signal is employed to identify the sign of the optical output signals. The effect of phase deviation and loss along the optical waveguides of the devices is also discussed

Sulfide Catabolism Ameliorates Hypoxic Brain Injury

The mammalian brain is highly vulnerable to oxygen deprivation, yet the mechanism underlying the brain’s sensitivity to hypoxia is incompletely understood. Hypoxia induces accumulation of hydrogen sulfide, a gas that inhibits mitochondrial respiration. Here, we show that, in mice, rats, and naturally hypoxia-tolerant ground squirrels, the sensitivity of the brain to hypoxia is inversely related to the levels of sulfide:quinone oxidoreductase (SQOR) and the capacity to catabolize sulfide. Silencing SQOR increased the sensitivity of the brain to hypoxia, whereas neuron-specific SQOR expression prevented hypoxia-induced sulfide accumulation, bioenergetic failure, and ischemic brain injury. Excluding SQOR from mitochondria increased sensitivity to hypoxia not only in the brain but also in heart and liver. Pharmacological scavenging of sulfide maintained mitochondrial respiration in hypoxic neurons and made mice resistant to hypoxia. These results illuminate the critical role of sulfide catabolism in energy homeostasis during hypoxia and identify a therapeutic target for ischemic brain injury

Industry Questions about Open Source Software in Business: Research Directions and Potential Answers

2014 6th International Workshop on Empirical Software Engineering in Practice, 12-13 Nov. 2014, Osaka, JapanAs open source software (OSS) has become an integral part of today's software businesses, many software companies rely on OSS to develop their customer solutions and products. On the other hand, they face various concerns in using OSS, such as technical support, quality, security and licensing issues. This paper focuses on OSS-related FAQ in industry, and tries to answer them or to provide research directions based on lessons learned from recent mining OSS repository researches

Industry Questions about Open Source Software in Business: Research Directions and Potential Answers

2014 6th International Workshop on Empirical Software Engineering in Practice, 12-13 Nov. 2014, Osaka, JapanAs open source software (OSS) has become an integral part of today's software businesses, many software companies rely on OSS to develop their customer solutions and products. On the other hand, they face various concerns in using OSS, such as technical support, quality, security and licensing issues. This paper focuses on OSS-related FAQ in industry, and tries to answer them or to provide research directions based on lessons learned from recent mining OSS repository researches

Importance of preoperative total colonoscopy and endoscopic resection after self-expandable metallic stent placement for obstructive colorectal cancer as a bridge-to-surgery

Abstract Background and aim Colonic self-expandable metallic stent (SEMS) placement enables preoperative total colonoscopy (TCS) in patients with obstructive colorectal cancer. Following SEMS placement, it is possible to assess the presence or absence of synchronous proximal colon cancers and perform preoperative endoscopic resection (ER) for neoplastic lesions proximal to the primary lesion. The objective of this study was to determine the usefulness and safety of preoperative TCS and ER after SEMS placement in patients with obstructive colorectal cancer. Methods From April 2016 to March 2022, we enrolled 100 patients with obstructive colorectal cancer who underwent SEMS placement, including 86 patients who underwent preoperative TCS after SEMS placement. Complications associated with preoperative TCS and ER after SEMS placement and the characteristics of the neoplastic lesions were assessed. Results The success rate of SEMS placement as bridge-to-surgery was 98.0%; six patients had associated complications. Preoperative TCS was performed 8 (range: 1–30) days after SEMS placement. Four patients had synchronous advanced cancers. Nine non-advanced synchronous cancers, 116 adenomas, and 18 sessile-serrated lesions were treated by preoperative TCS and ER after SEMS placement. No procedure-related complications, namely stent migration, bleeding, and perforation were observed. Forty-five patients underwent follow-up TCS 1 year after surgery. Only one patient with submucosal invasive cancer required a second surgery. Conclusions Preoperative TCS and ER after SEMS placement was performed with no complications. This approach allows preoperative evaluation of the entire colon and the treatment of precancerous lesions. (240 words

In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix

Our understanding of the development of the heart has been limited by a lack of in vitro cellular models. Here, the authors treat mouse embryonic stem cell-derived embryoid bodies with laminin-entactin (to mimic the developing microenvironment) and FGF4 to form heart organoids, with atrial and ventricular-like parts