Uncertainty Analysis of the Performance of a System of Best Management Practices for Achieving Phosphorus Load Reduction to Surface Waters

The repeated occurrence of Lake Erie’s harmful algal blooms suggests an inadequate phosphorus management system that results in excessive loads to the lake. In response, Canadian and United States’ governments have issued a new management objective, a 40% reduction in total and dissolved reactive phosphorus loads relative to 2008. To provide scientific evidence to guide managers toward achieving their management objective, we used the International Organization of Standardization (ISO) 31010 Bowtie Risk Analysis Tool to analyze the performance of the phosphorus management system. The effectiveness of agricultural best management practices (BMPs) and their adoption were combined into a Bayesian belief network model to predict watershed performance of each BMP. Then, the BMPs were analyzed for their probability of high risk phosphorus load reduction and achieving the management objective. Trade-offs were observed among the BMPs that will require decision makers to decide whether the management priority is to achieve the 40% load reduction objectives, or prevent further increase in the proportion of dissolved reactive phosphorus in the load, the identified culprit causing the repeated algal blooms

Mineralstickstoffgehalt im Boden in einem ökologischen und einem konventionellen Pflanzenproduktionssystem

An ecological five-year rotation of potato - spring barley with undersown grass clover – grass clover – grass clover – winter wheat with cover crop and a conventional three-year rotation of winter rape – winter wheat – spring barley systems were compared for soil mineral nitrogen content in 0-90cm from 2000-2003. The research was conducted on a field trial located at the Experimental Station in Osiny (Lublin province, Poland) on grey brown podzolic soil. In the ecological rotation, mineral nitrogen contents increased over time while in the conventional system the contents were the same after three years. However, depending on the crop and year there were large losses. The largest potential for Nmin losses was observed after grass clover in the ecological, and after rape in the conventional system

Testing the effectiveness of integrating community-based approaches for encouraging abandonment of female genital cutting into CARE\u27s reproductive health programs in Ethiopia and Kenya

CARE International, with technical support from the Frontiers in Reproductive Health Program completed a study in Ethiopia and Kenya designed to test the effectiveness of education activities using behavior change communication (BCC) approaches and advocacy activities by religious and other key leaders to abandon female genital cutting (FGC). In Ethiopia, the increased knowledge of harmful FGC effects and human rights issues translated to a positive attitude in support of FGC abandonment and an intention not to cut their daughters in the future. In Kenya, the analysis indicated mixed results in attitude and intended behavior change

Pause behaviour within reformulations and the proficiency level of second language learners of English

This research reports on a quantitative analysis of the combination of two types of disfluency, reformulations and pauses, in the speech of lower intermediate and advanced speakers of English as a second language (L2). The present study distinguishes between corrections and false starts within the category of reformulations as well as between silent and filled pauses. It focuses on the extent to which pause behavior within reformulations varies according to the stage of L2 development and the type of reformulation used. An analysis was made of 56 L2 speakers’ 2-min monologues. The results showed that lower intermediate and advanced speakers differed on the frequency of silent pauses inserted in corrections but not on their frequency in false starts. This suggests that false starts depend less on proficiency level, and may reflect temporary problems with conceptual encoding or extralinguistic factors that contribute to the efficacy of L2 production rather than difficulties with linguistic processing per se. The frequency of silent pauses rather than silent pause duration or the frequency and duration of filled pauses appeared to be the only marker to differentiate between false starts and corrections across the two proficiency groups

Current dietary recommendations for patients with cystic fibrosis

Cystic fibrosis (CF) is classified as metabolic and multisystem disease with autosomal recessive inheritance caused by mutations in the gene located on chromosome 7 encoding cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is a transmembrane chloride channel of epithelial cells and affects the activity of the mucous membrane of the sweat glands, airway epithelium, pancreatic ducts, vas deferens, bile ducts and intestines. In CF, increased concentration of chlorides in the sweat, pancreatic insufficiency and impaired absorption are observed as well as changes in the respiratory system related to, among others, impaired airway patency, weakening of the mucociliary clearance mechanism and the development of bacterial infections. CF is a chronic condition requiring comprehensive therapy. Nutritional treatment is an essential element of CF therapy. Malnutrition is a common complication in patient with CF and eating disorders. The majority of patients with CF have higher energy, protein and fat needs. In addition, supplementation with enzyme preparations, vitamins, sodium chloride, as well as the use of high-energy nutrients is recommended. The aim of the study was to evaluate current nutritional recommendations of patients with CF

Bringing ethical thinking to social change initiatives: Why it matters.

Norms-shifting interventions (NSI) seek to improve people's well-being by facilitating the transformation of harmful social norms, the shared rules of acceptable actions in a group that prop up harmful health behaviours. Community-based NSI aim for incremental normative change and complement other social and behaviour change strategies, addressing gender, other inequalities, and the power structures that hold inequalities in place. Consequently, they demand that designers and implementers-many who are outsiders-grapple with power, history, and community agency operating in complicated social contexts. Ethical questions include whose voices and values, at which levels, should inform intervention design; who should be accountable for managing resistance that arises during implementation? As interest and funding for NSI increases in lower and middle-income countries, their potential to yield sustained change is balanced by unintentionally reinforcing inequities that violate human rights and social justice pillars guiding health promotion efforts. A review of 125 articles on ethical considerations in public health, social justice, and human rights-where NSI actions intersect-indicated little guidance on practice. To begin to address this gap, we propose ten ethical values and practical ways to engage ethically with the social complexities of NSI and the social change they seek, and a way forward

In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin

Melanoma is the most deadly form of skin cancer with a yearly global incidence over 232,000 patients. Individuals with fair skin and red hair exhibit the highest risk for developing melanoma, with evidence suggesting the red/blond pigment known as pheomelanin may elevate melanoma risk through both UV radiation-dependent and -independent mechanisms. Although the ability to identify, characterize, and monitor pheomelanin within skin is vital for improving our understanding of the underlying biology of these lesions, no tools exist for real-time, in vivo detection of the pigment. Here we show that the distribution of pheomelanin in cells and tissues can be visually characterized non-destructively and noninvasively in vivo with coherent anti-Stokes Raman scattering (CARS) microscopy, a label-free vibrational imaging technique. We validated our CARS imaging strategy in vitro to in vivo with synthetic pheomelanin, isolated melanocytes, and the Mc1re/e, red-haired mouse model. Nests of pheomelanotic melanocytes were observed in the red-haired animals, but not in the genetically matched Mc1re/e; Tyrc/c (“albino-red-haired”) mice. Importantly, samples from human amelanotic melanomas subjected to CARS imaging exhibited strong pheomelanotic signals. This is the first time, to our knowledge, that pheomelanin has been visualized and spatially localized in melanocytes, skin, and human amelanotic melanomas