Right ventricular systolic function in Nigerians with heart failure secondary to hypertensive heart disease

Background: Right ventricular (RV) dysfunction has been shown to be a major contributor to the adverse outcomes in subjects with heart failure. Few studies evaluating the right ventricle in heart failure subjectshave been carried out in Sub-Saharan Africa. This study was therefore designed to evaluate the right ventricular systolic function in subjects with heart failure secondary to hypertensive heart disease presenting to the University College Hospital, Ibadan Nigeria.Methodology: Seventy-six subjects with heart failure secondary to hypertension and 92 normal controls underwent clinical, electrocardiographic and echocardiographic evaluation. Indices of right ventricular systolic function that were measured include tricuspid annular plane systolic excursion (TAPSE), tissue Doppler derived tricuspid peak systolic lateral annulus velocity(S') and right ventricular fractional areachange(RVFAC).Results: Sixty-two (81.6%) heart failure subjects had right ventricular systolic dysfunction, 31(40.8%) had abnormal TAPSE, 42(55.5%) had abnormal S' while 49(64.5%) had abnormal RVFAC. Elevated pulmonary artery systolic pressure was found in 25(32.9%) of the subjects. There was no relationship between the indices of right ventricular systolic function and the estimated systolic pulmonary artery pressures. The independent predictor of right ventricular systolic dysfunction was the right atrial size.Conclusion: Right ventricular systolic function is impaired in patients with heart failure secondary to hypertensive heart disease. There is no relationship between the indices of right ventricular systolic function and systolic pulmonary artery pressure. Furtherstudies are needed to assess right ventricular systolic function in Nigerians.Keywords: Hypertension, Heart Failure, Right ventricular dysfunction, Nigeria, Sub- Saharan Africa

Right ventricular systolic function in Nigerians with heart failure secondary to hypertensive heart disease

Background: Right ventricular (RV) dysfunction has been shown to be a major contributor to the adverse outcomes in subjects with heart failure. Few studies evaluating the right ventricle in heart failure subjects have been carried out in Sub-Saharan Africa. This study was therefore designed to evaluate the right ventricular systolic function in subjects with heart failure secondary to hypertensive heart disease presenting to the University College Hospital, Ibadan Nigeria. Methodology: Seventy-six subjects with heart failure secondary to hypertension and 92 normal controls underwent clinical, electrocardiographic and echocardiographic evaluation. Indices of right ventricular systolic function that were measured include tricuspid annular plane systolic excursion (TAPSE), tissue Doppler derived tricuspid peak systolic lateral annulus velocity(S') and right ventricular fractional areachange(RVFAC). Results: Sixty-two (81.6%) heart failure subjects had right ventricular systolic dysfunction, 31(40.8%) had abnormal TAPSE, 42(55.5%) had abnormal S' while 49(64.5%) had abnormal RVFAC. Elevated pulmonary artery systolic pressure was found in 25(32.9%) of the subjects. There was no relationship between the indices of right ventricular systolic function and the estimated systolic pulmonary artery pressures. The independent predictor of right ventricular systolic dysfunction was the right atrial size. Conclusion: Right ventricular systolic function is impaired in patients with heart failure secondary to hypertensive heart disease.There is no relationship between the indices of right ventricular systolic function and systolic pulmonary artery pressure. Further studies are needed to assess right ventricular systolic function in Nigerians. DOI: https://dx.doi.org/10.4314/ahs.v19i2.37 Cite as: Ifeoluwa AA, Adebiyi AA, Adeoye AM, Akinyemi A. Right ventricular systolic function in subjects with heart failure secondary to hypertensive heart disease. Afri Health Sci.2019;19(2): 2130-2139. https://dx.doi.org/10.4314/ahs.v19i2.3

Estimated incidence and Prevalence of noma in north central Nigeria, 2010-2018: A retrospective study.

BackgroundNoma is a spreading and fulminant disease believed to be native to Sub-Saharan Africa over the last decade and associated with low socioeconomic status of citizens of the region. Within this noma belt, most epidemiological reports regarding the disease have emanated from the north western region of Nigeria. However, our indigenous surgical mission encountered a substantial number of cases of noma and post-noma defects noteworthy of epidemiological representation across north central Nigeria.MethodsAll noma cases encountered within the 8-year study period were included and divided based on clinical signs into acute and sequelae groups. Incidence estimation was based on acute/recently active cases and was calculated using the statistical method proposed by the WHO Oral Health Unit (1994). Period prevalence of noma was calculated considering the population at risk in the zone.FindingsA total of 78 subjects were included in the study with age ranging from 2-75 years. Twelve subjects (15.4%) presented with acute disease while 66 (84.6%) had various forms of post-noma defects. The estimated incidence of noma in the north central zone was 8.3 per 100000 with a range of 4.1-17.9 per 100000 across various states. Period prevalence of noma which incorporated all cases seen within the study period was 1.6 per 100000 population at risk.ConclusionAlthough noma may be more prevalent in the north western region of Nigeria, substantial number of cases occurs within the north central zone which calls for deliberate public awareness campaign on disease risk factors and prevention, and education of primary health-care providers

Assessment of Water Quality Index and the Probable Human Health Implications of Consuming Packaged Groundwater from Abeokuta and Sagamu, Southwestern Nigeria

Background: Contamination of groundwater could result in serious and irreparable health problems for consumers. This study assessed the water quality and human health implications of metals in packaged groundwater from Abeokuta and Sagamu, southwestern Nigeria. Methods: One hundred and forty bags of the packaged groundwater were purchased and analyzed for physical and chemical parameters using standard procedures, while metals were determined using inductively coupled plasma optical emission spectrophotometry. Risk assessment of metals was estimated using hazard index (HI), hazard quotient (HQ), and cancer risk (CR). Water quality index (WQI) was also evaluated. Results: The observed physical and chemical parameters, except Mn and Fe, in the packaged groundwater samples were observed to be within the permissible limits of the World Health Organization. The WQI data indicated suitability for drinking purposes. The health risk data indicated high HQs > 1.0 for Ca (for adults and children at all the monitoring sites), Mn (children at all the sites, and adults at six sites), Mo (children at four sites, and adults at three sites), and Cu (children at three sites and adults at one site). Conclusion: The CRs of the packaged groundwater for Co and Ni at many sites revealed values > the acceptable limit of 1 × 10−4, indicating possible development of cancer by the consumers

Assessment of levels and health risk of Potentially Toxic Elements (PTEs) in selected sachet water packaged from groundwater resources in Ogun State, Nigeria

Background: Sachet water is a source of affordable drinking water for low-income socioeconomic class. However, contamination by potentially toxic elements (PTEs) could pose severe adverse health risk to consumers. Objective: The present study aimed at assessing the levels and health risk of PTEs in selected sachet water samples packaged from groundwater resources in Ogun State, Nigeria. Methods: A total of 140 bags of selected sachet water brands were purchased and analysed for eleven PTEs (some of which are rarely reported in Nigeria) using inductively coupled plasma - optical emission spectrophotometer. Recovery experiment was conducted to validate the performance of the used analytical instrument. Blank samples were also run to cancel the matrix effect of the analysing reagents, and to calculate the limit of detection. PTE data were evaluated for simple descriptive and inferential statistics using SPSS for Windows. Health risk assessment was conducted for hazard quotient (HQ), hazard index (HI) and cancer risk (CR). Results: Chromium (Cr) was the highest observed PTE in sachet water from Asero (707±1102 µg L−1), Isolu (363±374 µg L−1) and Makun-Shagamu (359±204 µg L−1) sites. The concentrations of Cr were higher than the permissible limit of the World Health Organization in 63% of the sachet water samples. Furthermore, the average contents of lead (Pb) and thallium (Tl) were observed at higher concentrations than the acceptable limits. The HQs exceeding the permissible threshold of 1.0 were observed for silver (Ag), aluminium (Al), arsenic (As), cadmium (Cd), Cr and Tl in 29% of the sachet water consumed by adults and children; indicating adverse health effects. The CRs of Cd and Cr at all the sampling locations, and As at few sites were higher than the acceptable limit of 1 × 10−4; suggesting possible development of cancer by the consumers. Conclusion: The high levels and health risk estimates of PTEs in the sachet water samples suggested unsafe for consumption. Periodic monitoring of PTEs in sachet water from the study area is recommended