ヒューマンエラー・マネージメントの観点からのフライトデッキ概念設計手法に関する研究

学位の種別: 論文博士審査委員会委員 : （主査）東京大学教授 李家 賢一, 東京大学教授 鈴木 真二, 東京大学教授 土屋 武司, 東京大学教授 西成 活裕, 東京大学准教授 今村 太郎, 宇宙航空研究開発機構セクションリーダ 舩引 浩平University of Tokyo(東京大学

Model experiment of magnetic field amplification in laser-produced plasmas via the Richtmyer-Meshkov instability

A model experiment of magnetic field amplification (MFA) via the Richtmyer-Meshkov instability (RMI) in supernova remnants (SNRs) was performed using a high-power laser. In order to account for very-fast acceleration of cosmic rays observed in SNRs, it is considered that the magnetic field has to be amplified by orders of magnitude from its background level. A possible mechanism for the MFA in SNRs is stretching and mixing of the magnetic field via the RMI when shock waves pass through dense molecular clouds in interstellar media. In order to model the astrophysical phenomenon in laboratories, there are three necessary factors for the RMI to be operative: a shock wave, an external magnetic field, and density inhomogeneity. By irradiating a double-foil target with several laser beams with focal spot displacement under influence of an external magnetic field, shock waves were excited and passed through the density inhomogeneity. Radiative hydrodynamic simulations show that the RMI evolves as the density inhomogeneity is shocked, resulting in higher MFA

MVA2023 Small Object Detection Challenge for Spotting Birds: Dataset, Methods, and Results

Small Object Detection (SOD) is an important machine vision topic because (i) a variety of real-world applications require object detection for distant objects and (ii) SOD is a challenging task due to the noisy, blurred, and less-informative image appearances of small objects. This paper proposes a new SOD dataset consisting of 39,070 images including 137,121 bird instances, which is called the Small Object Detection for Spotting Birds (SOD4SB) dataset. The detail of the challenge with the SOD4SB dataset is introduced in this paper. In total, 223 participants joined this challenge. This paper briefly introduces the award-winning methods. The dataset, the baseline code, and the website for evaluation on the public testset are publicly available.Comment: This paper is included in the proceedings of the 18th International Conference on Machine Vision Applications (MVA2023). It will be officially published at a later date. Project page : https://www.mva-org.jp/mva2023/challeng

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Specific peptide conjugation to a therapeutic antibody leads to enhanced therapeutic potency and thermal stability by reduced Fc dynamics

Abstract Antibody–drug conjugates are powerful tools for combatting a wide array of cancers. Drug conjugation to a therapeutic antibody often alters molecular characteristics, such as hydrophobicity and effector function, resulting in quality deterioration. To develop a drug conjugation methodology that maintains the molecular characteristics of the antibody, we engineered a specific peptide for conjugation to the Fc region. We used trastuzumab and the chelator (DOTA) as model antibody and payload, respectively. Interestingly, peptide/DOTA-conjugated trastuzumab exhibited enhanced antibody-dependent cellular cytotoxicity (ADCC) and increased thermal stability. Detailed structural and thermodynamic analysis clarified that the conjugated peptide blocks the Fc dynamics like a “wedge.” We revealed that (1) decreased molecular entropy results in enhanced ADCC, and (2) blockade of Fc denaturation results in increased thermal stability. Thus, we believe that our methodology is superior not only for drug conjugation but also as for reinforcing therapeutic antibodies to enhance ADCC and thermal stability