37 research outputs found
Domain wall displacement triggered by an AC current below threshold
It is theoretically demonstrated that a displacement of a pinned domain wall,
typically of order of m, can be driven by use of an ac current which is
below threshold value. The point here is that finite motion around the pinning
center by a low current is enhanced significantly by the resonance if the
frequency is tuned close to the pinning frequency as demonstrated by recent
experiment
Rad9 modulates the P21WAF1 pathway by direct association with p53
<p>Abstract</p> <p>Background</p> <p>Previous studies suggest that human <it>RAD9 </it>(hRad9), encoding a DNA damage checkpoint molecule, which is frequently amplified in epithelial tumor cells of breast, lung, head and neck cancer, participates in regulation of the tumor suppressor p53-dependent transactivation of pro-survival <it>P21</it><sup><it>WAF1</it></sup>. This study examined the exact mechanism of the hRad9 function, especially through the phosphorylation of the C-terminus, in the transcription regulation of <it>P21</it><sup><it>WAF1</it></sup>.</p> <p>Results</p> <p>The transfection of phosphorylation-defective <it>hRAD9 </it>mutants of C-terminus resulted in reduction of the p53-dependent <it>P21</it><sup><it>WAF1 </it></sup>transactivation; the knockdown of total hRad9 elicited an increased <it>P21</it><sup><it>WAF1 </it></sup>mRNA expression. Immunoprecipitation and a ChIP assay showed that hRad9 and p53 formed a complex and both were associated with two p53-consensus DNA-binding sequences in the 5' region of <it>P21</it><sup><it>WAF1 </it></sup>gene. The association was reduced in the experiment of phosphorylation-defective <it>hRAD9 </it>mutants.</p> <p>Conclusion</p> <p>The present study indicates the direct involvement of hRad9 in the p53-dependent <it>P21</it><sup><it>WAF1 </it></sup>transcriptional mechanism, presumably via the phosphorylation sites, and alterations of the hRad9 pathway might therefore contribute to the perturbation of checkpoint activation in cancer cells.</p
Ferromagnetism in a Hubbard model for an atomic quantum wire: a realization of flat-band magnetism from even-membered rings
We have examined a Hubbard model on a chain of squares, which was proposed by
Yajima et al as a model of an atomic quantum wire As/Si(100), to show that the
flat-band ferromagnetism according to a kind of Mielke-Tasaki mechanism should
be realized for an appropriate band filling in such a non-frustrated lattice.
Reflecting the fact that the flat band is not a bottom one, the ferromagnetism
vanishes, rather than intensified, as the Hubbard U is increased. The exact
diagonalization method is used to show that the critical value of U is in a
realistic range. We also discussed the robustness of the magnetism against the
degradation of the flatness of the band.Comment: misleading terms and expressions are corrected, 4 pages, RevTex, 5
figures in Postscript, to be published in Phys. Rev. B (rapid communication
Current-induced magnetization switching in MgO barrier magnetic tunnel junctions with CoFeB based synthetic ferrimagnetic free layers
We investigated the effect of using a synthetic ferrimagnetic (SyF) free
layer in MgO-based magnetic tunnel junctions (MTJs) on current-induced
magnetization switching (CIMS), particularly for application to spin-transfer
torque random access memory (SPRAM). The employed SyF free layer had a
Co40Fe40B20/ Ru/ Co40Fe40B20 and Co20Fe60B20/Ru/Co20Fe60B20 structures, and the
MTJs(100x(150-300) nm^2) were annealed at 300oC. The use of SyF free layer
resulted in low intrinsic critical current density (Jc0) without degrading the
thermal-stability factor (E/kBT, where E, kB, and T are the energy potential,
the Boltzmann constant, and temperature,respectively). When the two CoFeB
layers of a strongly antiferromagnetically coupled SyF free layer had the same
thickness, Jc0 was reduced to 2-4x10^6 A/cm^2. This low Jc0 may be due to the
decreased effective volume under the large spin accumulation at the CoFeB/Ru.
The E/kBT was over 60, resulting in a retention time of over ten years and
suppression of the write current dispersion for SPRAM. The use of the SyF free
layer also resulted in a bistable (parallel/antiparallel) magnetization
configuration at zero field, enabling the realization of CIMS without the need
to apply external fields to compensate for the offset field.Comment: 6 page
Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program.
OBJECTIVES: We evaluated the effectiveness of the Lao People's Democratic Republic's measles-rubella immunization program using the seroprevalence from two cross-sectional surveys. METHODS: The nationwide surveys occurred in 2014 and 2019 using a multistage cluster sampling, both requiring samples from 2184 individuals from 52 randomly selected villages. Immunoglobulin G titers, measured using enzyme-linked immunosorbent assay, were considered positive at ≥120 mIU/ml (measles) and ≥10 IU/ml (rubella). We calculated the vaccination-related reduction in the force of rubella infection and the number of congenital rubella syndrome cases averted in 2019. RESULTS: We collected 2135 (women: 55.2%, mean age: 23.2 years) and 2001 (52.7%, 23.1 years) samples in 2014 and 2019, respectively. During 2014-2019, immunoglobulin G prevalence increased from 83.9% (95% confidence interval [CI]: 83.8-84.0) to 98.3% (97.7-98.8) for measles and from 75.4% (75.3-75.5) to 87.8% (86.4-89.2) for rubella. The most plausible reduction in the average force of rubella infection was 100% (95% CI: 28-100) since vaccination started, averting 78 (95% CI: 42-128) congenital rubella syndrome cases in 2019. CONCLUSION: This is the first population-based study for measles and rubella at two different time points in developing countries. Measles and rubella seroprevalence increased significantly during 2014-2019, greatly exceeding the immunity thresholds for their elimination