Precise Estimation of Cosmological Parameters Using a More Accurate Likelihood Function

The estimation of cosmological parameters from a given data set requires a construction of a likelihood function which, in general, has a complicated functional form. We adopt a Gaussian copula and constructed a copula likelihood function for the convergence power spectrum from a weak lensing survey. We show that the parameter estimation based on the Gaussian likelihood erroneously introduces a systematic shift in the confidence region, in particular for a parameter of the dark energy equation of state w. Thus, the copula likelihood should be used in future cosmological observations.Comment: 5 pages, 3 figures. Maches version published by the Physical Review Letter

Modeling of weak lensing statistics. II. Configuration-space statistics

We investigate the performance of an analytic model of the 3D matter distribution, which combines perturbation theory with halo models, for weak-lensing configuration-space statistics. We compared our predictions for the weak-lensing convergence two-point and three-point correlation functions with numerical simulations and fitting formulas proposed in previous works. We also considered the second- and third-order moments of the smoothed convergence and of the aperture-mass. As in our previous study of Fourier-space weak-lensing statistics, we find that our model agrees better with simulations than previously published fitting formulas. Moreover, we recover the dependence on cosmology of these weak-lensing statistics and we can describe multi-scale moments. This approach allows us to obtain the quantitative relationship between these integrated weak-lensing statistics and the various contributions to the underlying 3D density fluctuations, decomposed over perturbative, two-halo, or one-halo terms.Comment: 11 page

Complement activation pathways associated with islet cell surface antibody (ICSA) derived from child patients with insulin-dependent diabetes mellitus (IDDM).

We studied the pathways of complement activation associated with the islet cell surface antibody (ICSA) obtained from sera of 7 patients (age less than 15 years) with insulin dependent diabetes mellitus (IDDM). The target cells were 51CR labelled rat islet cells and the complement source was human AB serum. Complement-dependent antibody mediated cytotoxicity (CAMC activity) was obtained using the percentage of cytotoxicity. CAMC activity of untreated sera was significantly inhibited by treating with EGTA or EDTA (p less than 0.001). The CAMC activity of EDTA-treated sera was significantly lower than that of EGTA-treated sera (p less than 0.001). In the inactivated human AB serum, it was lower than that of EGTA-treated sera (p less than 0.05), but not different from that of EDTA-treated sera. These results show that the complement activation associated with ICSA in patients occurred not only via the classical pathway but also via the alternative pathway.</p

Shear Power Spectrum Reconstruction using Pseudo-Spectrum Method

We develop a pseudo power spectrum technique for measuring the lensing power spectrum from weak lensing surveys in both the full sky and flat sky limits. The power spectrum approaches have a number of advantages over the traditional correlation function approach. We test the pseudo spectrum method by using numerical simulations with square-shape boundary that include masked regions with complex configuration due to bright stars and saturated spikes. Even when 25% of total area of the survey is masked, the method recovers the E-mode power spectrum at a sub-percent precision over a wide range of multipoles 100<l<10000. The systematic error is smaller than the statistical errors expected for a 2000 square degree survey. The residual B-mode spectrum is well suppressed in the amplitudes at less than a percent level relative to the E-mode. We also find that the correlated errors of binned power spectra caused by the survey geometry effects are not significant. Our method is applicable to the current and upcoming wide-field lensing surveys.Comment: 11 pages, 4 figures, accepted for publication in MNRA

Redox-Active Protein Thioredoxin-1 Administration Ameliorates Influenza A Virus (H1N1)-Induced Acute Lung Injury in Mice

Objectives: Influenza virus infections can cause severe acute lung injury leading to significant morbidity and mortality. Thioredoxin-1 is a redox-active defensive protein induced in response to stress conditions. Animal experiments have revealed that thioredoxin-1 has protective effects against various severe disorders. This study was undertaken to evaluate the protective effects of recombinant human thioredoxin-1 administration on influenza A virus (H1N1)-induced acute lung injury in mice. Design: Prospective animal trial. Setting: Research laboratory. Subjects: Nine-week-old male C57BL/6 mice inoculated with H1N1. Intervention: The mice were divided into a vehicle-treated group and recombinant human thioredoxin-1-treated group. For survival rate analysis, the vehicle or recombinant human thioredoxin-1 was administered intraperitoneally every second day from day -1 to day 13. For lung lavage and pathological analyses, vehicle or recombinant human thioredoxin-1 was administered intraperitoneally on days 1, 1, and 3. Measurements and Main Results: Lung lavage and pathological analyses were performed at 24, 72, and 120 hrs after inoculation. The recombinant human thioredoxin-1 treatment significantly improved the survival rate of H1N1-inoculated mice, although the treatment did not affect virus propagation in the lung. The treatment significantly attenuated the histological changes and neutrophil infiltration in the lung of H1N1-inoculated mice. The treatment significantly attenuated the production of tumor necrosis factor-a and chemokine (C-X-C motif) ligand 1 in the lung and oxidative stress enhancement, which were observed in H1N1-inoculated mice. H1N1 induced expressions of tumor necrosis factor-a and chemokine (C-X-C motif) ligand 1 in murine lung epithelial cells MLE-12, which were inhibited by the addition of recombinant human thioredoxin-1. The recombinant human thioredoxin-1 treatment started 30 mins after H1N1 inoculation also significantly improved the survival of the mice. Conclusions: Exogenous administration of recombinant human thioredoxin-1 significantly improved the survival rate and attenuated lung histological changes in the murine model of influenza pneumonia. The protective mechanism of thioredoxin-1 might be explained by its potent antioxidative and anti-inflammatory actions. Consequently, recombinant human thioredoxin-1 might be a possible pharmacological strategy for severe influenza virus infection in humans. (Crit Care Med 2013; 41:171-181

Association between upper limb movements during drumming and cognition in older adults with cognitive impairment and dementia at a nursing home: a pilot study

BackgroundDespite the association between motor dysfunction and dementia, quantitative assessment of dementia-related specific motor dysfunction in patients with severe dementia is difficult. Thus, this study aimed to develop a new method to measure upper limb motor function in people with dementia.MethodsWe examined the relationship between dementia severity and dementia-related specific motor dysfunction using the Mini-Mental State Examination (MMSE), a dementia screening test. Participants comprised 16 nursing home residents with a mean age of 86 years and MMSE score of 15.75 (range, 1–27) Points. Participants were seated in a circle and instructed to play a drum that was placed in their lap using mallets (drumsticks) in their dominant hand. Acceleration and gyroscopic sensors were attached to their wrists to collect data on arm movements while drumming. Upper limb motor characteristics were confirmed by recording acceleration and arm movement during drumming and analyzing the correlation with handgrip strength.ResultsHandgrip strength was correlated with arm elevation angle during drumming. The arm elevation angle displayed a significant regression equation with the MMSE score and showed the best regression equation along with handgrip strength (adjusted R2 = 0.6035, p = 0.0009).ConclusionWe developed a new method using drums to measure upper limb motor function in people with dementia. We also verified that the average arm elevation angle during drumming could predict cognitive dysfunction. This system may be used to monitor people with dementia in a simple and safe way

Cosmic Shear E/B-mode Estimation with Binned Correlation Function Data

In this work I study the problem of E/B-mode separation with binned cosmic shear two-point correlation function data. Motivated by previous work on E/B-mode separation with shear two-point correlation functions and the practical considerations of data analysis, I consider E/B-mode estimators which are linear combinations of the binned shear correlation function data points. I demonstrate that these estimators mix E- and B-modes generally. I then show how to define estimators which minimize this E/B-mode mixing and give practical recipes for their construction and use. Using these optimal estimators, I demonstrate that the vector space composed of the binned shear correlation function data points can be decomposed into approximately ambiguous, E- and B-mode subspaces. With simple Fisher information estimates, I show that a non-trivial amount of information on typical cosmological parameters is contained in the ambiguous mode subspace computed in this formalism. Next, I give two examples which apply these practical estimators and recipes to generic problems in cosmic shear data analysis: data compression and spatially locating B-mode contamination. In particular, by using wavelet-like estimators with the shear correlation functions directly, one can pinpoint B-mode contamination to specific angular scales and extract information on its shape. Finally, I discuss how these estimators can be used as part of blinded or closed-box cosmic shear data analyses in order to assess and find B-mode contamination at high-precision while avoiding observer biases.Comment: 15 pages, 5 figures, 3 appendices, MNRAS submitted, comments welcome