Guido da Siena’s narrative panels and the Madonna del Voto : the formation of the Marian civic identity in Sienese Art c.1260

This thesis examines the reconstructed altarpiece formed by the Madonna del Voto, the Coronation of the Virgin, and the twelve narrative panels dated circa 1267 and attributed to Guido da Siena, currently dispersed in museums in Europe and America. The reconstructed altarpiece is vital to the study of early Sienese art because of its association with the Madonna del Voto in Siena cathedral, the most venerated icon believed to be once on the high altar. If proven, it represents a significant rediscovery of an altarpiece commissioned to commemorate the miraculous intercession of the Virgin who granted Sienese victory over Florence in 1260 at the Battle of Montaperti, giving birth to Siena’s identity as ‘the City of the Virgin’. Moreover, it reveals a more comprehensive view of the precedent of the complex altarpiece, the Maestà by Duccio di Buoninsegna dated 1308-11. However, the unconventional format and the iconographical programme of Guido’s reconstructed altarpiece has been criticised, and its original location on the cathedral high altar is questioned. The four chapters of this thesis reassessed the validity of the reconstruction of Guido’s altarpiece and its original location on the high altar by combining the methodological tools of altarpiece studies and pictorial narrative studies. Chapter 1 clarified that the reconstruction is highly probable from a technical viewpoint. Chapter 2 proposed an alternative interpretation of the historical documents suggesting its original location on the high altar. Chapters 3 and 4 examined the two extra-biblical episodes (the Ascent of the Cross and the Coronation of the Virgin), which are often associated with Franciscan commissions, and argued that they were selected to emphasise the Virgin’s intercession. The reconstructed altarpiece of exceptional format and iconographical selection was thus probably an invention for the important commission for Siena cathedral where art embodied the Marian civic identity

It takes a village: Fixed-effects analysis of neighborhood collective efficacy and children's development

Background: Previous studies suggest that neighborhood social capital is associated with children's mental health. The purpose of this study was to examine the association between neighborhood collective efficacy and children's psychosocial development. Methods: We used data on children and their parents (n = 918) who were part of the Japanese study of Stratification, Health, Income, and Neighborhood (JSHINE) from 2010 to 2013 (wave 1 and wave 2). Households were recruited from the Tokyo metropolitan area through clustered random sampling. Changes in children's psychosocial development (assessed using a child behavioral checklist) between waves 1 and 2 were regressed on parents' perceptions of changes in neighborhood collective efficacy (social cohesion and informal social control). Results: Change in perception of neighborhood social cohesion was inversely associated with change in child total problems (β = −0.22; 95% confidence interval [CI]: −0.37 to −0.001; effect size d = −0.03). Change in perceptions of neighborhood informal social control was inversely associated with change in children's externalizing problems (β = −0.16; 95% CI: −0.30 to −0.03; d = −0.02). Conclusions: The results of these fixed-effects models suggest that strengthening neighborhood collective efficacy is related to improvements in child psychosocial development

Prenatal Alcohol Exposure and Child Psychosocial Behavior: A Sibling Fixed-Effects Analysis

Background: The association between low levels of alcohol consumption during pregnancy and children's health remains unclear because of the difficulty in ruling out residual genetic and environmental confounding factors. In this study, using a within-family sibling fixed effects design, we sought to examine the association between low prenatal alcohol exposures (PAE) and children's overall psychosocial behavior in a Japanese cohort.Methods: We used maternal and sibling data from the Japanese Study of Stratification, Health, Income and Neighborhood 2012-2013. Households were recruited from the Tokyo metropolitan area through clustered random sampling. Children under 18 years old who have siblings (n = 1,600) and their mothers were selected. PAE status was retrospectively measured, and classified by binominal and continuous measurements. Outcome measures of children's psychosocial behavior were assessed with the Child Behavior Checklist T-score.Results: Low PAE was significantly associated with the offspring's anxiety problems (β = 1.54, 95%CI = 0.26, 2.82) and internalizing problems (β = 2.73, 95%CI = 0.87, 4.60), and marginally significant with the offspring's total problem scores (β = 2.34, 95%CI = −0.24, 4.92). There was no significant difference in PAE between boys and girls when it comes to behavioral problems.Conclusions: Low PAE was associated with children's anxiety, internalizing problems and overall problems, taking into account possible unobserved genetic and environmental confounding influences

Sex-inducing effects toward planarians widely present among parasitic flatworms

Summary Various parasitic flatworms infect vertebrates for sexual reproduction, often causing devastating diseases in their hosts. Consequently, flatworms are of great socioeconomic and biomedical importance. Although the cessation of parasitic flatworm sexual reproduction is a major target of anti-parasitic drug design, little is known regarding bioactive compounds controlling flatworm sexual maturation. Using the planarian Dugesia ryukyuensis, we observed that sex-inducing substances found in planarians are also widespread in parasitic flatworms, such as monogeneans and flukes (but not in tapeworms). Reverse-phase HPLC analysis revealed the sex-inducing substance(s) eluting around the tryptophan retention time in the fluke Calicophoron calicophorum, consistent with previous studies on the planarian Bipalium nobile, suggesting that the substance(s) is likely conserved among flatworms. Moreover, six of the 18 ovary-inducing substances identified via transcriptome and metabolome analyses are involved in purine metabolism. Our findings provide a basis for understanding and modifying the life cycles of various parasitic flatworms.journal articl

It takes a village: Fixed-effects analysis of neighborhood collective efficacy and children's development

Background: Previous studies suggest that neighborhood social capital is associated with children's mental health. The purpose of this study was to examine the association between neighborhood collective efficacy and children's psychosocial development. Methods: We used data on children and their parents (n = 918) who were part of the Japanese study of Stratification, Health, Income, and Neighborhood (JSHINE) from 2010 to 2013 (wave 1 and wave 2). Households were recruited from the Tokyo metropolitan area through clustered random sampling. Changes in children's psychosocial development (assessed using a child behavioral checklist) between waves 1 and 2 were regressed on parents' perceptions of changes in neighborhood collective efficacy (social cohesion and informal social control). Results: Change in perception of neighborhood social cohesion was inversely associated with change in child total problems (β = −0.22; 95% confidence interval [CI]: −0.37 to −0.001; effect size d = −0.03). Change in perceptions of neighborhood informal social control was inversely associated with change in children's externalizing problems (β = −0.16; 95% CI: −0.30 to −0.03; d = −0.02). Conclusions: The results of these fixed-effects models suggest that strengthening neighborhood collective efficacy is related to improvements in child psychosocial development

公衆衛生対策として、妊婦への家庭訪問が出生アウトカムに及ぼす効果

京都大学0048新制・課程博士博士(社会健康医学)甲第19636号社医博第69号新制||社医||9(附属図書館)32672京都大学大学院医学研究科社会健康医学系専攻(主査)教授 佐藤 俊哉, 教授 今中 雄一, 教授 小西 郁生学位規則第4条第1項該当Doctor of Public HealthKyoto UniversityDFA

Effectiveness of home visits in pregnancy as a public health measure to improve birth outcomes

Background: Birth outcomes, such as preterm birth, low birth weight (LBW), and small for gestational age (SGA), are crucial indicators of child development and health. Purpose: To evaluate whether home visits from public health nurses for high-risk pregnant women prevent adverse birth outcomes. Methods: In this quasi-experimental cohort study in Kyoto city, Japan, high-risk pregnant women were defined as teenage girls (range 14-19 years old), women with a twin pregnancy, women who registered their pregnancy late, had a physical or mental illness, were of single marital status, non-Japanese women who were not fluent in Japanese, or elderly primiparas. We collected data from all high-risk pregnant women at pregnancy registration interviews held at a public health centers between 1 July 2011 and 30 June 2012, as well as birth outcomes when delivered from the Maternal and Child Health Handbook (N = 964), which is a record of prenatal check-ups, delivery, child development and vaccinations. Of these women, 622 women were selected based on the home-visit program propensity score-matched sample (pair of N = 311) and included in the analysis. Data were analyzed between January and June 2014. Results: In the propensity score-matched sample, women who received the home-visit program had lower odds of preterm birth (odds ratio [OR], 0.62; 95% confidence interval [CI], 0.39 to 0.98) and showed a 0.55-week difference in gestational age (95% CI: 0.18 to 0.92) compared to the matched controlled sample. Although the program did not prevent LBW and SGA, children born to mothers who received the program showed an increase in birth weight by 107.8 g (95% CI: 27.0 to 188.5). Conclusion: Home visits by public health nurses for high-risk pregnant women in Japan might be effective in preventing preterm birth, but not SGA