451 research outputs found
Establishment of rostrocaudal polarity in tectal primordium:engrailed expression and subsequent tectal polarity
Coarse-Graining and Self-Dissimilarity of Complex Networks
Can complex engineered and biological networks be coarse-grained into smaller
and more understandable versions in which each node represents an entire
pattern in the original network? To address this, we define coarse-graining
units (CGU) as connectivity patterns which can serve as the nodes of a
coarse-grained network, and present algorithms to detect them. We use this
approach to systematically reverse-engineer electronic circuits, forming
understandable high-level maps from incomprehensible transistor wiring: first,
a coarse-grained version in which each node is a gate made of several
transistors is established. Then, the coarse-grained network is itself
coarse-grained, resulting in a high-level blueprint in which each node is a
circuit-module made of multiple gates. We apply our approach also to a
mammalian protein-signaling network, to find a simplified coarse-grained
network with three main signaling channels that correspond to cross-interacting
MAP-kinase cascades. We find that both biological and electronic networks are
'self-dissimilar', with different network motifs found at each level. The
present approach can be used to simplify a wide variety of directed and
nondirected, natural and designed networks.Comment: 11 pages, 11 figure
Severe hepatic injury caused by orlistat
ArticleAMERICAN JOURNAL OF MEDICINE. 119(8): E7-E7journal articl
Autistic adults exhibit highly precise representations of others’ emotions but a reduced influence of emotion representations on emotion recognition accuracy
Epidemiology of hepatocellular carcinoma in Japan
The original publication is available at www.springerlink.comArticleJOURNAL OF GASTROENTEROLOGY. 44:102-107 (2009)journal articl
Disulfide relays and phosphorylative cascades: Partners in redox-mediated signaling pathways
Modifications of specific amino-acid residues of proteins are fundamental in order to modulate different signaling processes among which the cascade of phosphorylation represents the most effective example. Recently, also, the modification of the redox state of cysteine residues of certain proteins, which is a widespread mechanism in the regulation of protein function, has been proposed to be involved in signaling pathways. Growing evidence shows that some transcription factors could be modulated by both oxidation and phosphorylation. In particular, the pathways regulated by the mitogen activated protein (MAP) kinases represent well-established examples of the cross talk between redox-mediated signaling and phosphorylative cascades. This review will compare the two modes of signal transduction and propose an evolutionary model of a partnership of the two mechanisms in the eukaryotic cell, with redox-mediated signals being more specific and ancestral and phosphorylative signals being more diffuse but predominant in signal propagation. © 2005 Nature Publishing Group All rights reserved
Anti-Helicobacter pylori seropositivity: influence on severity and treatment response in patients with chronic hepatitis C
The definitive version is available at www.blackwell-synergy.comArticleJOURNAL OF VIRAL HEPATITIS. 14(1): 48-54 (2007)journal articl
The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism.
Lack of association between FCRL3 and Fc gamma RII polymorphisms in Japanese type 1 autoimmune hepatitis
ArticleCLINICAL IMMUNOLOGY. 122(3): 338-342 (2007)journal articl
DOWN-REGULATION OF SREBP-1C IS ASSOCIATED WITH THE DEVELOPMENT OF BURNED-OUT NASH
Abstracts of the International Liver Congress™ 2010 – the 45th annual meeting of the European Association for the Study of the Liver (EASL)ArticleJOURNAL OF HEPATOLOGY. 52(Suppl. 1):S373-S374 (2010)conference pape
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